A5103250806- Plant and Fungal Interactions Research
- Advanced NMR Techniques and Applications
- Plant Virus Research Studies
- HIV Research and Treatment
- Electron Spin Resonance Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- RNA Research and Splicing
- HIV-related health complications and treatments
- Pharmacological Effects and Toxicity Studies
- Ion channel regulation and function
- Ocular Diseases and Behçet’s Syndrome
- Cardiac electrophysiology and arrhythmias
- Advanced Glycation End Products research
- Immune Cell Function and Interaction
- Systemic Lupus Erythematosus Research
- Cancer-related molecular mechanisms research
- Ginseng Biological Effects and Applications
- Inflammatory Biomarkers in Disease Prognosis
- HIV/AIDS Research and Interventions
- Autoimmune and Inflammatory Disorders Research
- Reproductive System and Pregnancy
- Cytomegalovirus and herpesvirus research
- Enzyme Structure and Function
- Cancer-related gene regulation
Qilu Hospital of Shandong University
2011-2022
Jining First People's Hospital
2018
National Health and Family Planning Commission
2015-2017
China Medical University
2015-2017
University of California, San Francisco
2016
Hunan Agricultural University
2015
Natural killer (NK) cells are the first line of defense against pathogens immune system and also play an important role in resistance HIV. The activating receptor NKG2C inhibitory NKG2A co-modulate function NK by recognizing same ligand, HLA-E. However, on viral set point prediction HIV disease progression have been rarely reported. In this study, we determined expression or surface from 22 individuals with primary infection (PHI) stage 23 HIV-negative normal control (NC) subjects. CD4+ T...
Purpose The purpose of this study was to characterize tissue-specific alterations in metabolism hyperpolarized (HP) gluconeogenic precursors 13C-lactate and 13C-pyruvate by rat liver kidneys under conditions fasting or insulin-deprived diabetes. Methods Seven normal rats were studied MR spectroscopic imaging both HP fed 24 h states, seven additional scanned after induction diabetes streptozotocin (STZ) with insulin withdrawal. Phosphoenolpyruvate carboxykinase (PEPCK) expression levels also...
Abstract This study aimed to investigate the effects of ginsenoside Rh2 on proliferation, apoptosis, and migration human medulloblastoma cell line Daoy, as well explore potential mechanisms effects. The Daoy was cultured in vitro treated with or without Rh2. CCK‐8 assay performed effect survival using a counting Kit‐8. Cell proliferation assessed by BrdU assay. apoptosis determined flow cytometry analysis. detected modified two‐chamber MiR‐31 mimic NC control were transfected into cells...
Objective: To investigate the relationship between cognitive impairment and hippocampal morphological functional changes in HIV-seropositive patients. Methods: Thirty HIV+ patients who complain of memory decrease 15 healthy volunteers were recruited. Performances learning assessed using Hopkins Verbal Learning Test-Revised (HVLT-R) Brief Visuospatial Memory (BVMT-R). Bilateral volume, apparent diffusion coefficient (ADC) value, fractional anisotropy magnetic resonance spectroscopy variables...
Behçet's disease (BD) is a chronic multisystemic inflammatory disorder characterized by recurrent oral and genital aphthous ulcers, uveitis skin lesions. Recurrent ulcer (RAU) the most prevalent mucosal in humans. The pathogenesis thrombopoiesis of BD RAU have not been fully clarified. To reveal haemostatic dysfunctions patients with RAU, we evaluated levels coagulant, anticoagulant fibrinolytic parameters these patients.Factor Ⅷ clotting activity (FVIII:c), protein C antigen (PC:Ag), total...
To assess the effect that hormonal disturbances have on HIV prognosis in male patients. A prospective follow-up study was conducted among patients who started antiretroviral therapy (ART) between July 1, 2011 and June 30, 2014. The final session occurred before December 31, We examined correlation pre-ART hormone levels disease prognosis. Kaplan–Meier method multivariate Cox proportional hazard model were used to identify hormone-related predictors of immunological failure mortality. During...
The TWIK-related potassium channel (TREK-1) can be regulated by different stimuli. However, it is not clear whether some antiarrhythmics affect the activity of TREK-1. In present study, effect bepridil on TREK-1 currents investigated.In a stably-expressed HEK-293 cell line (HEK-TREK-1), U251MG cells, and isolated mouse ventricular myocytes, current action potentials were recorded patch-clamp technique. standard voltage protocol was 200 ms constant potential at 20 mV, followed bya 500 ramp...
Objective The objective of this study was to apply new methods in hyperpolarized (HP) 13C magnetic resonance imaging (MRI) characterize tissue‐specific alterations the metabolism HP gluconeogenic precursors 13C‐lactate and 13C‐pyruvate by rat liver kidneys vivo both fasting insulin deprivation diabetes. Methods Solutions were magnetically using method dissolution dynamic nuclear polarization (DNP), for use spectroscopic MRI anesthetized rats. Seven normal rats scanned fed 24h states, seven...
Aim: To identify genes associated with the prognosis of head and neck squamous cell carcinoma (HNSC) potential molecular targets for therapy. Materials Methods: Gene Expression Profiling Interactive Analysis, Human Protein Atlas, University ALabama at Birmingham CANcer, LinkedOmics, cBioPortal, Cell Counting Kit 8, polymerase chain reaction were used in this study. Results: The expression level nuclear transport factor 2 (NUTF2) was elevated HNSC tissues poor patients. NUTF2-targeted...