A5052309533- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Metabolism, Diabetes, and Cancer
- Cancer therapeutics and mechanisms
- Pancreatic function and diabetes
- Cervical Cancer and HPV Research
- Schizophrenia research and treatment
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Nausea and vomiting management
- Estrogen and related hormone effects
- Receptor Mechanisms and Signaling
- Neutropenia and Cancer Infections
- Intraperitoneal and Appendiceal Malignancies
- Chemotherapy-induced organ toxicity mitigation
- Protein Kinase Regulation and GTPase Signaling
- Biochemical Acid Research Studies
- Chemotherapy-related skin toxicity
- PARP inhibition in cancer therapy
- Immune Cell Function and Interaction
- Pregnancy and preeclampsia studies
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Treatments and Mutations
- Complementary and Alternative Medicine Studies
- Pregnancy and Medication Impact
The University of Texas Health Science Center at Houston
2014-2025
Memorial Hermann
2015-2025
Texas Medical Center
2020-2025
University of Central Lancashire
2013-2024
The University of Melbourne
2023
New Zealand Association of Counsellors
2023
Memorial Hermann–Texas Medical Center
2020
Predictive Science (United States)
2018
University Physicians
2017
Texas Southern University
2012-2016
Anti-CD3 monoclonal antibodies (mAbs) are potent immunosuppressive agents used in clinical transplantation. However, the activation-related adverse side effects associated with these mAbs have prompted development of less toxic nonmitogenic anti-CD3 mAb therapies. At present, functional and biochemical consequences T cell exposure to is unclear. In this study, we examined early signaling events triggered by a mAb. Like mitogenic mAb, changes receptor (TCR) complex, including ζ chain tyrosine...
Purpose To describe and assess the current utilization of complementary alternative medicines (CAMs) in women with a diagnosis either gynecologic or breast cancer evaluate their reasons for use. Patients Methods This study included 250 female patients from Multidisciplinary Breast Center Gynecologic Oncology The University Texas M.D. Anderson Cancer (Houston, TX). were selected by having an odd-numbered medical record number, they contacted before clinic visit. goals explained, verbal...
Two normal men had blood taken for measurement of plasma aldosterone, cortisol and renin activity every 30 minutes while supine 24 hours. Aldosterone secretion occurred in spurts as is true cortisol. Moreover, peak levels these two adrenal hormones were synchronous during late sleep on arising, was frequently. However peaks later the day not with aldosterone.
145-2C11, a hamster mAb directed against the mouse CD3 complex, is potent immunosuppressive agent. Upon initial treatment, 145-2C11 triggers systemic release of multiple cytokines that responsible for acute toxicity mAb. This cellular activation consequence cross-linking between T lymphocytes and Fc gamma R-bearing cells, mediated by high affinity murine Rs. Repeated injections result in onset neutralizing humoral response. Therefore, there has been an increased interest developing...
Novel antipsychotic drugs (APDs) have enhanced therapeutic actions compared to ‘typical’ APDs. However,clinical studies indicate that some induce marked weight gain. We attempted model this effect in female Wistar rats given olanzapine chronically at 4 mg/kg b.i.d (4.5 h between injections). Such showed gain, which was statistically significant after only a single day of treatment, although gain increased up plateau 10 days treatment. Cessation treatment led rapid loss, withdrawal. The...
Anti-CD3 mAbs with low FcR affinity prolong graft survival in the absence of cytokine-mediated toxicity observed conventional anti-CD3 treatment. Previous studies have shown that FcR-nonbinding suppress immune responses, at least part, by delivering a partial signal resulting Th1 unresponsiveness. In this study, biochemical and functional consequences treatment for various activated T cell populations were examined. contrast to cells, anti-CD3-treated Th2 cells secreted IL-4 proliferated....
Genistein, an isoflavone putative tyrosine kinase inhibitor, was used to investigate the coupling of insulin receptor activation four metabolic effects in isolated rat adipocyte. Genistein inhibited insulin-stimulated glucose oxidation a concentration-dependent manner with ID50 25 micrograms/ml and complete inhibition at 100 micrograms/ml. also prevented insulin's (10(-9) M) isoproterenol-stimulated lipolysis 15 effect 50 The genistein (25 micrograms/ml) not reversed by supraphysiological...
This study was a follow-up investigation of the psychological symptomatology exhibited by sexually abused girls. Seventy-three girls ages 7 to 13 were compared with 69 clinical controls and normal at 6-and 12-month assessments. Assessment measures included Children's Depression Inventory (CDI), State-Trait Anxiety for Children (STAIC), Piers-Harris Self-Concept Scale, Child Behavior Checklist (CBCL parent version). All findings self-report nonsignificant except on 6-month follow-up, in which...
The recent approval of olaparib and niraparib as maintenance therapy can significantly affect the management ovarian cancer. Clinical benefits, however, come with trade-offs in adverse events costs.
The effects of partially purified insulin-generated mediators from rat skeletal muscle were compared to those insulin on intact adipocytes. Insulin and mediator stimulated both pyruvate dehydrogenase glycogen synthase activity In contrast, glucose oxidation 3-O-methylglucose transport, whereas had no effect. Insulin-generated cannot account for all the pleiotropic insulin, especially membrane-controlled processes.
: The objective of this study was to determine the efficacy mifepristone (RU-486) in women with advanced or recurrent endometrioid adenocarcinoma low-grade endometrial stromal sarcoma (LGESS).: Mifepristone (RU-486; 200 mg orally) given daily patients progesterone receptor-positive LGESS. Patients were evaluated every 4 weeks for toxicity and response. Quality-of-life data obtained using Memorial Symptom Assessment Scale Functional Cancer Therapy.: Twelve 13 enrolled evaluable first phase...