A5091896413- Metabolism, Diabetes, and Cancer
- Global Health Care Issues
- Healthcare Policy and Management
- Cancer, Lipids, and Metabolism
- Primary Care and Health Outcomes
- Health Systems, Economic Evaluations, Quality of Life
- Chronic Disease Management Strategies
- Diabetes Treatment and Management
- Health disparities and outcomes
- Diabetes and associated disorders
- Research in Social Sciences
- Family Support in Illness
- Cancer Risks and Factors
- Employment and Welfare Studies
- Diabetes Management and Research
- Pancreatic and Hepatic Oncology Research
- Schizophrenia research and treatment
- Lung Cancer Treatments and Mutations
- Diabetes Management and Education
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Global Cancer Incidence and Screening
- Mental Health Treatment and Access
- Cancer survivorship and care
- Estrogen and related hormone effects
- Gastric Cancer Management and Outcomes
Finnish Institute for Health and Welfare
2016-2025
University of Helsinki
2019-2023
Helsinki University Hospital
2023
Tampere University
2019-2023
Pirkanmaa Hospital District
2019
University of Eastern Finland
2017-2018
National Institutes of Health
2010-2017
Urban Big Data Centre
2016
University of Glasgow
2016
Erasmus University Rotterdam
2016
Objective To analyse mortality and life expectancy in people with alcohol use disorder Denmark, Finland Sweden. Method A population‐based register study including all patients admitted to hospital diagnosed (1 158 486 person‐years) from 1987 2006 Results Life was 24–28 years shorter than the general population. From 2006, difference between population increased men (Denmark, 1.8 years; Finland, 2.6 Sweden, 1.0 years); women, Denmark (0.3 years) but decreased (−0.8 Sweden (−1.8 years). People...
Objective To examine the associations between an onset of serious mental disorders before age 25 with subsequent employment, income and education outcomes. Methods Nationwide cohort study including individuals ( n = 2 055 720) living in Finland 1988–2015, who were alive at end year they turned 25. Mental disorder diagnosis ages 15 was used as exposure. The level education, employment status, annual wage or self‐employment earnings, total 52 (measurement years 1988–2015) Results All...
OBJECTIVE To investigate how risk of end-stage renal disease (ESRD) among patients with type 1 diabetes has changed over time and further the is affected by age, sex, period diagnosis diabetes. RESEARCH DESIGN AND METHODS A cohort including all <30 years old diagnosed in Finland 1965–2011 was followed until start replacement therapy, death, or end follow-up at 2013. Altogether, 29,906 were included. The main outcome cumulative ESRD, accounting for death as a competing risk. RESULTS up...
Individuals with severe mental disorders have an impaired ability to work and are likely receive income transfer payments as their main source of income. However, the magnitude this phenomenon remains unclear. Using longitudinal population cohort register data, authors conducted a case-control study examine levels employment personal before after first hospitalization for serious disorder.All individuals (N=50,551) who had been hospitalized schizophrenia, other nonaffective psychosis, or...
Type 1 diabetes has been associated with a significant reduction in life expectancy. Major advances treatment of type have improved survival. However, expectancy for under contemporary care is not known.Health registers were used to obtain data on all people Finland 1964-2017 and their mortality 1972-2017. Survival analyses study long-term trends survival abridged period table methods calculate estimates. Causes death examined consider development.Study included 42,936 persons 6,771 deaths....
Abstract Objective To investigate whether increased prevalence of type 2 diabetes (T2DM) in women with polycystic ovary syndrome (PCOS) translates into risk diabetic complications. Design A cohort study based on the nationwide Diabetes Finland database. The main analysis included 1288 PCOS and T2DM 177,555 without (controls). Moreover, a sub-analysis that compared each woman to five controls matching diagnosis date age at onset was conducted. Methods for complications (i.e. composite...
Objective This study evaluates how extended childbirth education intervention affects first‐time mothers’ fear of and its manifestation during pregnancy. Method A randomised controlled trial was conducted. total 659 mothers were recruited before week 14 gestation the first ultrasound screening at hospital's maternity outpatient clinic. The randomly assigned into an group (n = 338) or a control 321). received all available regular education. In addition, enhanced 2‐hour hospital. Outcome...
Aims: Many countries experience persistent or increasing socioeconomic disparities in specialist care. This study examines the distribution of elective surgery from 1992 to 2003 Finland. Methods: Administrative registers were used identify common procedures performed all public and private hospitals Finland 1992—2003. Patients' individual sociodemographic data came 1990—2003 census employment statistics databases. First coronary revascularisation, hip knee replacement, lumbar disc operation,...
OBJECTIVE To estimate long-term cumulative risk of end-stage renal disease (ESRD) after diagnosis type 2 diabetes. RESEARCH DESIGN AND METHODS This nationwide population-based inception cohort study included 421,429 patients with diabetes diagnosed in 1990–2011; were followed until the end 2013. Data linkage between several national health care registers Finland, covering 100% population, enabled inclusion almost all inhabitants who started taking medication or hospitalized for Cumulative...
Increasing wellbeing problems among physicians may lead to serious consequences in health care and means prevent such development are called for. This study examined longitudinal associations between workload changes distress, sleep quality workability whether positive social relations at work would protect from problems. A baseline survey was conducted 2006 for a random sample of 5000 (n = 2841, response rate 57%). In 2015, the follow-up sent those 2 206 who gave their consent 1462, 68.3%)....
BackgroundEarlier research suggests poorer outcome of cancer care among people with severe mental illness (SMI).AimsTo assess the effect stage at presentation, comorbidities and treatment on differences in survival patients without a history SMI Finland.MethodThe total population first diagnosis 1990-2013 was drawn from Finnish Cancer Registry. Hospital admissions because deaths were obtained administrative registers. We calculated Kaplan-Meier estimates Cox regression models to examine...
Ovarian cancer is one of the most lethal cancers and women with type 2 diabetes (T2D) have even poorer survival from it. We assessed prognosis ovarian in treated metformin, other forms antidiabetic medication, or statins.Study cohort consisted T2D diagnosed Finland 1998-2011. They were identified a nationwide database (FinDM), being linked to several national registers. Patients grouped according their medication three years preceding diagnosis. The Aalen-Johansen estimator was used describe...
Lack of social contacts has been associated with an increased risk cancer mortality, but it is not known whether living alone increases the incidence or case fatality. We examined association between incidence, case-fatality and all-cause mortality in eight most common cancers. All patients their first diagnosis 2000–2017 were identified from nationwide Finnish Cancer Registry. Information on arrangements was derived Statistics Finland. The analyses conducted using Poisson regression. total...
Abstract Purpose The worldwide prevalence of diabetes mellitus (DM) continues to increase. As DM is linked various ophthalmological comorbidities, it crucial understand the incidence and treatment patterns these complications minimise burden for patient healthcare system. This study aims evaluate diabetic macular oedema (DME) proliferative retinopathy (PDR) analyse intravitreal (IVT) responses in Finnish population with diabetes. Methods A nationwide data register containing details over...
Finland decentralised its universal healthcare system and introduced market reforms in the 1990s. Despite a commitment to equity, previous studies have identified persistent socio-economic inequities healthcare, with patterns of service use that are more pro-rich than most other European countries. To examine whether similar patterning existed for mortality amenable intervention primary or specialist care, we investigated trends by income group from 1992-2003.We analysed all cause, total...
To obtain evidence of the effects metformin and statins on incidence ovarian cancer in women with type 2 diabetes (T2D).A retrospective cohort study nested case-control study.The data were obtained from a database (FinDM) combining information several nationwide registers.A 137 643 over 40 years old diagnosed T2D during 1996-2011 Finland.In full analysis Poisson regression was used to estimate hazard ratios (HR) relation ever use metformin, insulin other oral anti-diabetic medication or...
Infrared thermography (IRT) is a non-invasive technology for screening and early detection of diabetic foot. Real-world data the Delphi technique were used to assess IRT's potential effect on typical care pathways foot their costs in Finnish healthcare setting.The most identified from national registers 2011 2017. The IRT terms avoidable episodes was assessed by panel including specialists (n=13). By combining series decision-analytic models, each pathway sensitivity model assumptions...
Objectives Endoscopic sinus surgery (ESS) is a common operation typically performed due to chronic rhinosinusitis (CRS). There are limited data on the nationwide ESS rate and factors contributing its regional variation. The aim was evaluate causing variation of rate. Design Cross-sectional observational study. Setting A ll patients undergoing in Finland 2013–2015. Population Nationwide Finnish population aged 15 years or over. Main outcome measures per 1000 inhabitants between 2013 2015 all...
Abstract Objective We examined the length and continuity of antidepressant treatment factors associated with long‐term among adults. Methods Nationwide data from all reimbursed prescriptions in 1994–2003 were linked patients' retrieved Statistics Finland Finnish Hospital Discharge Register. Logistic regression models used to analyse long term use antidepressants. Results The annual prevalence increased 3.6% 1994 7.3% 2003. Short‐term (<3 months) decreased 58% 1995 51% 2000 (≥12 18 21%. In...
Background: The present study examines the role of six aspects socio-economic status (income, occupational position, education, unemployment, living alone and type residential area) in mortality among types 1 2 diabetic people Finland. All-cause causes deaths (for example, alcohol diseases) are assessed. Methods: People with diabetes aged 30–79 years 2000–03 were identified from national registers. data comprised 528 734 person-years 18 841 deaths. Relative risks obtained Poisson regression...
To address the possible association between use of metformin, other forms antidiabetic medication (ADM) and statins with incidence breast cancer in women type 2 diabetes (T2D). Data were collected from a Finnish nationwide database (FinDM). The study cohort consisted diagnosed T2D 1996–2011 Finland. In full-cohort analysis, Poisson regression was used to estimate hazard ratios (HRs) relation insulin, oral ADM statins. nested case–control up 20 controls matched for age duration each case...