A5067956344- Ovarian function and disorders
- Reproductive Biology and Fertility
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Lipid metabolism and disorders
- Cardiovascular Disease and Adiposity
- Ovarian cancer diagnosis and treatment
- Hormonal and reproductive studies
- Pregnancy and preeclampsia studies
- Reproductive Health and Contraception
- Obesity, Physical Activity, Diet
- Liver Disease Diagnosis and Treatment
- Acute Myocardial Infarction Research
- Diet, Metabolism, and Disease
- Sexual Differentiation and Disorders
- Eating Disorders and Behaviors
- Urticaria and Related Conditions
- Bariatric Surgery and Outcomes
- Circadian rhythm and melatonin
- Diet and metabolism studies
- Cardiac electrophysiology and arrhythmias
- Diabetes Treatment and Management
- Cardiovascular and Diving-Related Complications
- Coronary Interventions and Diagnostics
- Cardiovascular Syncope and Autonomic Disorders
Oulu University Hospital
2016-2025
University of Oulu
2016-2025
Northern Ostrobothnia Hospital District
2024
Abstract Objective Polycystic ovary syndrome (PCOS) is associated with many cardiovascular disease (CVD) risk factors, such as obesity, type 2 diabetes mellitus and hypertension. However, it remains debatable whether the presence of multiple CVD factors translates to increased events. Design A prospective, population-based Northern Finland Birth Cohort 1966. Methods Individuals an expected date birth in 1966 have been followed from birth. Women cohort were classified having PCOS according...
Obesity affects the majority of women with polycystic ovary syndrome (PCOS), but previous studies are inconsistent about prevalence obesity and importance weight gain in development syndrome. Our objective was to explore association between weight, gain, hyperandrogenism, PCOS from adolescence late adulthood. The study includes a prospective Northern Finland Birth Cohort 1966 including 5889 females born followed at ages 14, 31, 46 years. setting general community. Women presenting both...
What are the respective roles of polycystic ovary syndrome (PCOS), long-term weight gain and obesity for development prediabetes or Type 2 diabetes mellitus (T2DM) by age 46 years?The risk T2DM in women with PCOS is mainly due to overweight obesity, although these two factors have a synergistic effect on T2DM.PCOS associated an increased T2DM. However, per se BMI remained unclear.In prospective, general population-based follow-up birth cohort 1966 (n = 5889), postal questionnaires were sent...
Abstract Objectives Previous studies have shown good correlation between polycystic ovarian morphology (PCOM) and serum anti-Müllerian hormone (AMH) levels. We evaluated the utility of AMH as a surrogate for PCOM part ovary syndrome (PCOS) diagnosis by describing how use different cut-off values would change prevalence PCOS. Methods A general population-based birth cohort study. Anti-Müllerian concentrations were measured from samples taken at age 31 years (n = 2917) using...
Abstract Introduction Current use of combined hormonal contraceptives worsens glucose tolerance and increases the risk type 2 diabetes mellitus at late fertile age, but impact their former on metabolism disorders is still controversial. Material methods This was a prospective, longitudinal birth cohort study with long‐term follow‐up consisting 5889 women. The population has been followed birth, ages 1, 14, 31 46. In total, 3280 (55.7%) women were clinically examined 2780 also underwent 2‐h...
Abstract Objective To investigate whether increased prevalence of type 2 diabetes (T2DM) in women with polycystic ovary syndrome (PCOS) translates into risk diabetic complications. Design A cohort study based on the nationwide Diabetes Finland database. The main analysis included 1288 PCOS and T2DM 177,555 without (controls). Moreover, a sub-analysis that compared each woman to five controls matching diagnosis date age at onset was conducted. Methods for complications (i.e. composite...
Abstract Context Polycystic ovary syndrome (PCOS) is associated with many traditional cardiovascular disease risk factors, but it unclear whether PCOS an independent factor for hypertension. Objective To investigate in a population-based setup associates the of hypertension independently body mass index (BMI) and manifestations. Design Cross-sectional assessments Northern Finland Birth Cohort 1966 at ages 31 46 years. Setting General community. Participants Women who reported both...
Abstract STUDY QUESTION Is there an association between premature ovarian insufficiency (POI) and severe autoimmune diseases before after POI diagnosis? SUMMARY ANSWER Women with had at least one hospital-treated disorder preceding diagnosis 2.6 times more often compared matched female controls, a 2- to 3-fold risk for these several years diagnosis. WHAT IS KNOWN ALREADY It has been suggested that autoimmunity is important factor in the pathogenesis of POI. Estimations prevalence cases...
Objective The use of combined hormonal contraceptives (CHCs) worsens glucose tolerance, but the risk for metabolism disorders remains controversial. Design study is a prospective longitudinal population-based cohort study. Methods was based on population that comprised 1879 women born in 1966. At age 46, answered questionnaire contraceptive and underwent an oral tolerance test. Glucose indices were evaluated current CHC ( n = 153), progestin-only (POC, 842), non-hormonal users 884). Results...
The aim of the study was to determine association body mass index (BMI), self-reported symptoms or diagnosis polycystic ovary syndrome (PCOS), and hyperandrogenemia with occurrence gestational diabetes mellitus (GDM) through reproductive life.A cohort women born in 1966 were investigated at ages 14, 31 46. Women PCOS (presence both oligo-amenorrhea hirsutism) age formally diagnosed ovaries (PCO)/PCOS by 46 formed group (srPCOS, n = 222) compared without (n 1357). We also hyperandrogenism...
What is the prospective risk of Type 2 diabetes (T2D) in Nordic women with polycystic ovary syndrome (PCOS) compared to controls?
Women with a history of gestational diabetes (GDM) have an increased risk developing type 2 (T2DM). We studied the for T2DM in women and without GDM relation to body mass index (BMI) examined whether insulin treatment associates T2DM. In addition, we investigated after had changed 15 years. used data by linking four registers; Medical Birth Register, Hospital Discharge Register Primary Care run THL Finnish Institute Health Welfare, Reimbursement Statistics Social Insurance Institution...
Abstract Objective Up to 70% of women with polycystic ovary syndrome (PCOS) have pre‐obesity or obesity. The aim this study was investigate whether PCOS more weight‐loss attempts than without PCOS, regardless BMI. Moreover, women's weight perceptions in relation previous were evaluated. Methods A population‐based birth cohort included ( n = 278) and (control individuals, 1560) who examined at ages 31 46 years questionnaires clinical examinations. Results Women had compared control...
Sudden cardiac death (SCD) is a significant mode of causing 15-20% all deaths in high-income countries. Coronary artery disease (CAD) the most common cause SCD both sexes, and often first manifestation underlying CAD women. This case-control study aimed to determine factors associated with due women.The group consisted women CAD-related (N = 888) derived from Fingesture conducted Northern Finland 1998 2017. All SCDs underwent medicolegal autopsy. The control angiographically verified without...
The purpose of this prospective, population-based cohort study was to evaluate the roles polycystic ovary syndrome (PCOS), obesity, weight gain, and hyperandrogenemia in development hypertensive disorders pregnancy (HDP) through fertile age both PCOS non-PCOS women. population-NFBC1966 (Northern Finland Birth Cohort 1966)-allowed a long-term follow-up women from 14 until 46 years who developed HDP (n=408) or did not (n=3373). diagnosis confirmed by combining hospital discharge records, data...
Previous studies of women in their 20s and 30s have reported impaired autonomic function with polycystic ovary syndrome (PCOS). We aimed to study, for the first time, whether PCOS is associated cardiac independent metabolic hormonal status late reproductive years. A prospective Northern Finland Birth Cohort 1966 (NFBC1966) study including 5889 born followed through age 46. At that age, n=3706/5123 (72%) answered postal questionnaires n=3280/5123 (64%) participated clinical examination....
Abstract Context The role of androgen excess as a contributing factor to abnormal glucose metabolism (AGM) and insulin resistance in women remains controversial. Objective To investigate whether hyperandrogenemia (HA) estimated by serum testosterone (T) level free index (FAI) at ages 31 46 years is associated with resistance, secretion AGM age 46. Design Prospective study including 5889 females followed years. Setting General community. Participants Women HA were compared normoandrogenic...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)