A5035750127- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Advanced X-ray and CT Imaging
- Cardiovascular Disease and Adiposity
- Infective Endocarditis Diagnosis and Management
- Radiation Dose and Imaging
- Coronary Interventions and Diagnostics
- Cardiovascular Health and Disease Prevention
- Liver Disease Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Cerebrovascular and Carotid Artery Diseases
- Heart Rate Variability and Autonomic Control
- Atrial Fibrillation Management and Outcomes
- Congenital Heart Disease Studies
- Acute Myocardial Infarction Research
- Venous Thromboembolism Diagnosis and Management
- Cardiac electrophysiology and arrhythmias
- Pulmonary Hypertension Research and Treatments
- Cardiac pacing and defibrillation studies
- Medical Imaging Techniques and Applications
- Cardiac Arrhythmias and Treatments
- Transplantation: Methods and Outcomes
- Heart rate and cardiovascular health
Semmelweis University
2015-2024
Cardiovascular Research Center
2014
Different visceral fat compartments have several systemic effects and may play a role in the development of both insulin resistance cardiovascular diseases. In last couple years special attention has been paid to epicardial adipose tissue (EAT), which can be quantified by non-invasive cardiac imaging techniques. The is unique compartment between myocardium pericardium sharing common embryologic origin with depot. Epicardial specific roles, its local on function are incorporated complex...
Both genetic and environmental factors play a role in the pathogenesis of type 2 diabetes cardiovascular diseases. The magnitude influences may vary different populations can be investigated by twin studies. In this cross-sectional study, 101 (63 monozygotic 38 dizygotic) adult pairs (n = 202; mean age: 44.3 ± 15.8 years) were investigated. Past medical history was recorded physical examination performed. Fasting venous blood samples taken for measuring laboratory parameters. For assessing...
Background and aimsVisceral obesity is a marker of dysfunctional adipose tissue ectopic fat infiltration. Many studies have shown that visceral dysfunction has close relationship with cardiovascular disease. For better identification adiposity dysfunction, the index (VAI) used. Coronary artery calcium score (CACS) known to strong correlation total plaque burden therefore provides information about severity coronary atherosclerosis. CACS predictor cardiac events it refines risk assessment...
Background: Genetics have a strong influence on calcified atherosclerotic plaques; however, data regarding the heritability of noncalcified plaque volume are scarce. We aimed to evaluate genetic versus environmental influences calcium (coronary artery calcification) score, and volumes by coronary computed tomography angiography in adult twin pairs without known disease. Methods: In prospective BUDAPEST-GLOBAL (Burden Atherosclerotic Plaques Study Twins—Genetic Loci Burden Lesions) classical...
Several inflammatory biomarkers were found to be associated with an increased risk of cardiovascular disease. Neutrophil-to-lymphocyte ratio (NLR) is a marker subclinical inflammation that increases the stress response. Visceral adiposity index (VAI) calculated as combination anthropometric and metabolic parameters reflects both extent function visceral adipose tissue. Given association obesity diseases, it plausible inflammation-CVD modulated by amount Thus, our aim was examine between NLR...
Contrast media (CM) extravasation is a well-known complication of CT angiography (CTA). Our prospective randomized control study aimed to assess whether four-phasic CM administration protocol reduces the risk compared routinely used three-phasic in coronary CTA. Patients referred CTA due suspected artery disease were included study. All patients received 400 mg/ml iomeprol injected with dual-syringe automated injector. into injection-protocol group, bolus 85 ml followed by 40 75%:25%...
Cardiovascular autonomic function is often assessed in patients with diabetes by measuring heart rate variability and baroreflex sensitivity, the heritability of which not fully understood. The present study was aimed to determine effects genetic environmental factors on sensitivity monozygotic dizygotic adult healthy twin pairs.A total 101 (63 monozygotic, 38 dizygotic) pairs (n = 202; mean age 44.3 years) were investigated. Anthropometric variables serum metabolic markers measured, while...
Detecting early-stage atherosclerosis is an important step towards cardiovascular disease prevention. Coronary artery calcium (CAC) score a sensitive and non-invasive tool for detecting coronary atherosclerosis. Higher serum uric acid (SUA) levels are known to be associated with diseases. However, there inconsistency regarding the independence of association. The aim our study was assess association CAC SUA in asymptomatic population. scans 281 participants were analyzed voluntary screening...
ABSTRACT The heritability of coronary atherosclerotic plaque burden, geometry, and phenotypes associated with increased cardiometabolic risk are largely unknown. primary aim the Burden Atherosclerotic Plaques Study in Twins—Genetic Loci Lesions ( BUDAPEST‐GLOBAL ) study is to evaluate influence genetic environmental factors on burden artery disease. By design this a prospective, single‐center, classical twin study. In total, 202 twins (61 monozygotic pairs, 40 dizygotic same‐sex pairs) were...
Structured reporting in cardiac imaging is strongly encouraged to improve quality through consistency. The Coronary Artery Disease - Reporting and Data System (CAD-RADS) was recently introduced facilitate interdisciplinary communication of coronary CT angiography (CTA) results. We aimed assess the agreement between manual automated CAD-RADS classification using a structured platform.Five readers prospectively interpreted 500 angiographies platform that automatically calculates score based on...
BackgroundCoronary CT angiography (CTA) is an established tool to rule out coronary artery disease. Performance of CTA highly dependent on patients' heart rates (HRs). Despite widespread use β-blockers for CTA, few studies have compared various agents used achieve adequate HR control.ObjectiveWe sought assess if the ultrashort-acting β-blocker intravenous esmolol at least as efficacious standard care metoprolol control during CTA.MethodsPatients referred with a >65 beats/min despite oral...
Abstract Obstructive sleep apnea (OSA) is associated with an increased risk of cardiovascular disease. Previous studies have assessed the relationship between OSA and coronary artery disease (CAD) using calcium score (CAC) measurements. However, limited data are available regarding association non‐calcified plaque burden. We therefore aimed to assess CAD severity as by computed tomography angiography (CTA) OSA. Forty‐one adult subjects (59 ± 9 years, 15 men) underwent a 256‐slice CTA, which...
Both genetic and environmental factors play role in the pathogenesis of metabolic syndrome. The magnitude influences on components syndrome may vary different populations. Aims: present study was aimed to determine effects risk characteristic for Methods: A total 101 (63 monozygotic 38 dizygotic) adult twin pairs (n = 202; mean age: 43.3±15.8 years) were investigated. Medical history recorded physical examination carried out each subject. Fasting venous blood samples used measuring...
Abstract Objective To assess whether anthropometrics, clinical risk factors, and coronary artery calcium score (CACS) can predict the need of further testing after CT angiography (CTA) due to non-diagnostic image quality and/or presence significant stenosis. Methods Consecutive patients who underwent CTA suspected disease (CAD) were included in our retrospective analysis. We used multivariate logistic regression receiver operating characteristics analysis containing anthropometric factors:...
Filtered back projection (FBP) and adaptive statistical iterative reconstruction (ASIR) are ubiquitously applied in the of coronary CT angiography (CCTA) datasets. However, currently no data is available on impact a model-based filter (MBAF2), recently developed for dedicated cardiac scanner.Our aim was to determine effect MBAF2 subjective objective image quality parameters arteries CCTA.Images 102 consecutive patients referred CCTA were evaluated. Four reconstructions images (FBP, ASIR,...
Various adipose tissue compartments play an important role in the development of cardiometabolic diseases. The quantity different fat is influenced by genetic and environmental factors. aim our study was to evaluate magnitude effects on epicardial, subcutaneous visceral (EAT, SAT VAT) quantities a cohort adult twin pairs.In this cross-sectional we investigated twins (57 monozygotic (MZ) 33 dizygotic (DZ) same-gender pairs; 180 subjects). We measured EAT volume using electrocardiogram-gated...
Cardiac allograft vasculopathy (CAV) is among the top causes of death 1 year after heart transplantation (HTx). Coronary CT angiography (CTA) a potential alternative to invasive imaging in diagnosis CAV. However, higher rate (HR) HTx recipients prompts use retrospective ECG-gating, which associated with radiation dose, major concern this patient population. Therefore, we sought evaluate feasibility and image quality low-radiation-dose prospectively ECG-triggered coronary CTA recipients.In...
Cardiac CT is increasingly applied for planning and follow-up of transcatheter aortic valve implantation (TAVI). However, there are no data available on reverse remodelling after TAVI assessed by CT. Therefore, we aimed to evaluate the predictors prognostic value left ventricular (LV) following using angiography.We investigated 117 patients with severe, symptomatic stenosis (AS) who underwent scanning before procedure a mean time 2.6 years TAVI. We found significant reduction in LV mass...
Transcatheter aortic valve implantation (TAVI) can improve left ventricular (LV) mechanics and survival. Data on the predictive value of atrial (LA) strain following TAVI are scarce. We aimed to evaluate association LA measured shortly post-TAVI with functional anatomical reverse remodeling LV, its mortality.We prospectively investigated 90 patients who underwent TAVI. Transthoracic echocardiography including analysis was performed after repeated 6 months later. CT angiography (CTA) for...
Whether hypoattenuated leaflet thickening (HALT) following transcatheter aortic valve implantation (TAVI) carries a risk of subclinical brain injury (SBI) is unknown. We investigated whether HALT associated with SBI detected on magnetic resonance imaging (MRI), and post-TAVI impacts the patients' cognition outcome. prospectively enrolled 153 patients (age: 78.1 ± 6.3 years; female 44%) who underwent TAVI. Brain MRI was performed shortly 6 months later to assess occurrence acute silent...
Abstract Despite the well-known importance of left atrial (LA) mechanics in diastolic function, data are scarce regarding prognostic power LA longitudinal strain and its potential added value risk stratification an elderly population. Accordingly, our aim was to determine long-term 2D speckle-tracking echocardiography-derived peak (PALS) a community-based screening sample. Three hundred fourteen volunteers were retrospectively identified from population-based program (mean age 62 ± 11 years;...