A5018809373- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Pulmonary Hypertension Research and Treatments
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Heart Failure Treatment and Management
- Cardiac pacing and defibrillation studies
- Cardiac Structural Anomalies and Repair
- Peripheral Artery Disease Management
- Hemodynamic Monitoring and Therapy
- Blood properties and coagulation
- Congenital Heart Disease Studies
- Dermatological and Skeletal Disorders
- Venous Thromboembolism Diagnosis and Management
- Skin and Cellular Biology Research
- Advanced MRI Techniques and Applications
- Cellular Mechanics and Interactions
- Cardiovascular Effects of Exercise
- Advanced X-ray and CT Imaging
- Advanced Neuroimaging Techniques and Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac and Coronary Surgery Techniques
- Cardiac electrophysiology and arrhythmias
Semmelweis University
2016-2025
Karolinska University Hospital
2025
Karolinska Institutet
2020-2024
Heim Pál Gyermekkórház
2017
University of Cambridge
2008-2015
Boston Children's Hospital
2006
The voltage-dependent anion channel (VDAC) of the outer mitochondrial membrane mediates metabolic flow, Ca2+, and cell death signaling between endoplasmic reticulum (ER) networks. We demonstrate that VDAC1 is physically linked to Ca2+-release inositol 1,4,5-trisphosphate receptor (IP3R) through molecular chaperone glucose-regulated protein 75 (grp75). Functional interaction channels was shown by recombinant expression ligand-binding domain IP3R on ER or surface, which directly enhanced Ca2+...
Left ventricular diastolic pressure estimation is essential for characterization of heart failure (HF). Patients with normal resting left atrial (LA) pressures (LAP), but steep LAP elevation on exertion, pose a particular diagnostic challenge. Current recommendations echocardiographic have limited accuracy. Our aim was to investigate whether LA mechanical alterations assessed by strain (LA-GS) can contribute non-invasive diagnostics. Simultaneous and right catheterization (RHC) data at rest...
Background/Objectives: To assess the association between moderate N-terminal natriuretic peptide (NT-proBNP) and cardiac alterations prognosis in septuagenarians without heart failure (HF). Methods: From STROKESTOP II screening study, 230 individuals aged 75/76 years with NT-proBNP < 900 ng/L were randomly selected. Subjects persistent atrial fibrillation (AF), more than mild valvular disease, or HF excluded. Echocardiography was performed. ≥ 125 paroxysmal AF (pAF) on thumb ECG used as...
We aimed to correlate left atrial appendage (LAA) structure and function with the history of stroke/transient ischemic attack (TIA) in patients fibrillation (AF). analyzed data 649 AF who were scheduled for catheter ablation. Patients underwent cardiac computed tomography transesophageal echocardiography before The LAA morphologies depicted by categorized into 4 groups: cauliflower, chicken wing, swan, windsock shapes. mean age was 61.3 ± 10.5 years, 33.9% women. prevalence stroke/TIA 7.1%....
Untwisting contributes to left ventricular filling through suction generation. We sought investigate diastolic function and untwisting dynamics in different forms of hypertrophy: athlete's heart hypertrophic cardiomyopathy. Elite athletes kayaking, canoeing rowing (n=28), patients with cardiomyopathy (HCM, n=15) healthy sedentary volunteers (n=13) were compared. Left volumes, wall thickness-to-volume ratio assessed by cardiac MRI. Following conventional tissue Doppler measurements, untwist...
Pseudoxanthoma elasticum (PXE, OMIM 264800) is a rare autosomal recessive disorder with ectopic mineralization and fragmentation of elastin fibers. It caused by mutations the ABCC6 gene that leads to decreased serum levels inorganic pyrophosphate (PPi) anti-mineralization factor. The occurrence severe complications among PXE patients highlights importance early diagnosis so prompt multidisciplinary care can be provided patients. We aimed examine dermal connective tissue nonlinear optical...
There are no consistently confirmed predictors of atrial fibrillation (AF) recurrence after catheter ablation. Therefore, we aimed to study whether left appendage volume (LAAV) and function influence the long-term AF ablation, depending on type.AF patients who underwent point-by-point radiofrequency ablation cardiac computed tomography (CT) were included in this analysis. LAAV LAA orifice area measured by CT. Uni- multivariable Cox proportional hazard regression models performed determine...
Migration of cells within epithelial sheets is an important feature embryogenesis and other biological processes. Previous work has demonstrated a role for inositol 1,4,5-trisphosphate (IP(3))-mediated calcium signalling in the rearrangement epidermal (also known as hypodermal cells) during embryonic morphogenesis Caenorhabditis elegans. However mechanism by which IP(3) production stimulated unknown. produced action phospholipase C (PLC). We therefore surveyed PLC family C. elegans using...
Abstract Aims Left ventricular ( LV ) mechanics have been extensively investigated in heart failure with preserved ejection fraction HF p EF overshadowing for a long time the potential role of left atrium LA that setting. Soluble suppression tumorigenicity‐2 receptor ST 2) is novel biomarker pro‐fibrotic burden . We hypothesized due to thinner wall, fibrotic myocardial changes as indicated by elevated 2 levels might more readily be reflected impairments rather than performance. Methods and...
The combination of deformation analysis with conventional wall motion scoring (WMS) has been shown to increase the diagnostic sensitivity dobutamine stress echocardiography (DSE). feasibility and power WMS is largely improved by contrast agents; however, they are not used in analysis, as agents generally considered render strain measurement unfeasible.To assess tissue velocity (TVI)- 2D speckle tracking (ST)-based during contrast-enhanced DSE; show whether there an incremental value...
Real-time three-dimensional transesophageal echocardiography has increased our understanding of the distinct pathomechanisms underlying functional, ischaemic or degenerative mitral regurgitation. However, potential differences in dynamic morphology between subtypes prolapse have scarcely been investigated. In order to compare behavior different phenotypes valve prolapse, real-time recordings 77 subjects, 27 with Barlow disease (BD), 32 Fibroelastic deficiency (FED) and 18 normal controls...
Background: Cardiac amyloidosis (CA) is a rare, progressive, infiltrative cardiac disease. Light chain (AL) and transthyretin (ATTR) are in the background almost all cases. New, easily available diagnostic tools recently introduced novel therapies for both types of CA put this disease into field interest. Increased left ventricular wall thickness (IWT) detected by echocardiography generally thought to be necessary part diagnosis. We aimed determine proportion patients without IWT, define...
Background: Rheumatoid arthritis (RA) patients have a shorter life expectancy than the general population primarily due to cardiovascular comorbidities. Objectives: To characterize arterial aging in RA. Patients and Methods: Coronary calcium score (CCS) were available from 112 RA patients; out of these patients, follow-up CCS measured for 54 randomly selected individuals. Control obtained MESA database (includes 6,000 &lt; participants); age was calculated CCS. Results: significantly...
Abstract Aortic stenosis has become the most prevalent valvular disease with increasing life expectancy and ageing of population, representing a significant clinical burden for health care providers. Its treatment been revolutionized by transcatheter aortic valve replacement (TAVR) as safe minimally invasive option elderly patients. Left ventricular (LV) functional measurement is particular importance before TAVR, however, increased afterload significantly influences conventional...
BackgroundAn increase in the pulmonary capillary wedge pressure (PAWP) has been shown to impact on inherent relationship between arterial compliance (PAC) and vascular resistance (PVR), thus augmenting pulsatile relative resistive load of right ventricle. However, PAWP comprises integration both steady components. We sought address differential these distinct components PAC–PVR a cohort patients with heart failure. Methods ResultsThe study population consisted 192 hemodynamic findings...
Cardiac CT is increasingly applied for planning and follow-up of transcatheter aortic valve implantation (TAVI). However, there are no data available on reverse remodelling after TAVI assessed by CT. Therefore, we aimed to evaluate the predictors prognostic value left ventricular (LV) following using angiography.We investigated 117 patients with severe, symptomatic stenosis (AS) who underwent scanning before procedure a mean time 2.6 years TAVI. We found significant reduction in LV mass...
A hallmark of mitral stenosis (MS) is the markedly altered left ventricular (LV) loading. As most methods used to determine LV performance in MS patients are influenced by loading conditions, previous studies have shown conflicting results. The present study calculated elastance, which a robust method quantify function. We demonstrate that elevated but normalizes after valve repair and might be result reflex pathways. Additionally, we show less compliant than normal due combination right...