A5086986862- Autophagy in Disease and Therapy
- Endoplasmic Reticulum Stress and Disease
- Mitochondrial Function and Pathology
- RNA Interference and Gene Delivery
- Genomics, phytochemicals, and oxidative stress
- Neurobiology and Insect Physiology Research
- Insect Resistance and Genetics
- Plant responses to water stress
- Cellular transport and secretion
- Parkinson's Disease Mechanisms and Treatments
- Lysosomal Storage Disorders Research
- Insect behavior and control techniques
- RNA regulation and disease
- Lipid metabolism and biosynthesis
- Genetics, Aging, and Longevity in Model Organisms
- Machine Learning in Bioinformatics
- Gene Regulatory Network Analysis
- 14-3-3 protein interactions
- Bioinformatics and Genomic Networks
- Genetic Neurodegenerative Diseases
- Biomedical Text Mining and Ontologies
- Cannabis and Cannabinoid Research
- Neurological disorders and treatments
- Sirtuins and Resveratrol in Medicine
- Cassava research and cyanide
Eötvös Loránd University
2015-2024
Institute for Soil Sciences
2021
Autophagy is a major molecular mechanism that eliminates cellular damage in eukaryotic organisms. Basal levels of autophagy are required for maintaining homeostasis and functioning. Defects the autophagic process implicated development various age-dependent pathologies including cancer neurodegenerative diseases, as well accelerated aging. Genetic activation has been shown to retard accumulation damaged cytoplasmic constituents, delay incidence extend life span genetic models. This implies...
Autophagy functions as a main route for the degradation of superfluous and damaged constituents cytoplasm. Defects in autophagy are implicated development various age-dependent degenerative disorders such cancer, neurodegeneration tissue atrophy, accelerated aging. To promote basal levels process pathological settings, we previously screened small molecule library novel autophagy-enhancing factors that inhibit myotubularin-related phosphatase MTMR14/Jumpy, negative regulator autophagic...
Signaling networks represent the molecular mechanisms controlling a cell's response to various internal or external stimuli. Most currently available signaling databases contain only part of complex network intertwining pathways, leaving out key interactions processes. Hence, we have developed SignaLink3 (http://signalink.org/), value-added knowledge-base that provides manually curated data on pathways and integrated from several types (interaction, regulation, localisation, disease, etc.)...
Background: Autophagy, a lysosome-mediated self-degradation process of eukaryotic cells, serves as main route for the elimination cellular damage [1–3]. Such damages include aggregated, oxidized or misfolded proteins whose accumulation can cause various neurodegenerative pathologies, including Huntington's disease (HD). Objective: Here we examined whether enhanced autophagic activity alleviate neurophatological features in Drosophila model HD (the transgenic animals express human mutant...
The compound eye of the fruit fly Drosophila melanogaster is one most intensively studied and best understood model organs in field developmental genetics. Herein we demonstrate that autophagy, an evolutionarily conserved selfdegradation process eukaryotic cells, essential for development this organism. Autophagic structures accumulate a specific pattern developing disc, predominantly morphogenetic furrow (MF) differentiation zone. Silencing several autophagy genes (Atg) primordium severely...
Abstract Ageing is driven by the progressive, lifelong accumulation of cellular damage. Autophagy (cellular self-eating) functions as a major cell clearance mechanism to degrade such damages, and its capacity declines with age. Despite physiological medical significance, it remains largely unknown why autophagy becomes incapable effectively eliminating harmful materials in many cells at advanced ages. Here we show that age-associated defects autophagic degradation occur both early late...
-methyladenine (6mA) in the DNA is a conserved epigenetic mark with various cellular, physiological and developmental functions. Although presence of 6mA was discovered few years ago nuclear genome distantly related animal taxa just recently mammalian mitochondrial (mtDNA), accumulating evidence at present seriously questions
Myotubularin (MTM) and myotubularin-related (MTMR) lipid phosphatases catalyze the removal of a phosphate group from certain phosphatidylinositol derivatives. Because some these substrates are required for macroautophagy/autophagy, during which unwanted cytoplasmic constituents delivered into lysosomes degradation, MTM MTMRs function as important regulators autophagic process. Despite its physiological medical significance, specific role individual MTMR paralogs in autophagy control remains...
The fruit fly Drosophila melanogaster emerges as an affordable, genetically tractable model of behavior and brain diseases. However, despite the surprising level evolutionary conservation from flies to humans, significant genetic circuit-level differences hinder interpretability models for human disease. Therefore, facilitate fly-to-human translation with more direct behavior-level comparison, we surveyed rarely-exploited, rich behavioral repertoire alterations relevant Parkinson’s disease...
The fruit fly Drosophila melanogaster emerges as an affordable, genetically tractable model of behavior and brain diseases. However, despite the surprising level evolutionary conservation from flies to humans, significant genetic circuit-level differences hinder interpretability models for human disease. Therefore, facilitate fly-to-human translation with more direct behavior-level comparison, we surveyed rarely-exploited, rich behavioral repertoire alterations relevant Parkinson’s disease...
Abstract The authors have requested that this preprint be removed from Research Square.
Abstract The fruit fly Drosophila melanogaster emerges as an affordable, genetically tractable model of behavior and brain diseases. However, despite the surprising level evolutionary conservation from flies to humans, significant genetic, circuit-level behavioral differences hinder interpretability models for human disease. Therefore, allow a more direct fly-versus-human comparison, we surveyed rarely exploited, rich repertoire with genetic alterations relevant Parkinson’s disease (PD),...