A5051566831- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Meningioma and schwannoma management
- Cancer, Hypoxia, and Metabolism
- Innovations in Medical Education
- Medical Imaging Techniques and Applications
- Neuroblastoma Research and Treatments
- Cancer-related molecular mechanisms research
- Clinical Reasoning and Diagnostic Skills
- Brain Tumor Detection and Classification
- Advanced Radiotherapy Techniques
- MRI in cancer diagnosis
- Nanoplatforms for cancer theranostics
- Empathy and Medical Education
- Ferroptosis and cancer prognosis
- Biomedical and Chemical Research
- Mobile Health and mHealth Applications
- Pituitary Gland Disorders and Treatments
- MicroRNA in disease regulation
- Management of metastatic bone disease
- Cancer-related cognitive impairment studies
- Innovative Teaching Methods
- Medical Practices and Rehabilitation
- Advanced Electron Microscopy Techniques and Applications
Klinikum rechts der Isar
2016-2025
Technical University of Munich
2016-2025
Deutsche Gesellschaft für Hämatologie und Medizinische Onkologie
2022
Dana-Farber Cancer Institute
2022
Klinik und Poliklinik für Neurologie
2014-2021
München Klinik
2016-2021
Medizinische Hochschule Hannover
2016
University Hospital Heidelberg
2016
University of Zurich
2016
Heinrich Heine University Düsseldorf
2016
Optimal treatment and precise classification for anaplastic glioma are needed. The objective long-term follow-up of NOA-04 is to optimize the sequence patients with gliomas. Patients were randomized 2:1:1 receive standard radiotherapy (RT) (arm A), procarbazine, lomustine vincristine (PCV) B1), or temozolomide (TMZ) B2). Primary endpoint was time-to-treatment-failure (TTF), defined as progression after 2 lines therapy any time before if no further administered. Exploratory analyses examined...
Mobile apps are an evolving trend in the medical field. To date, few oncological context exist.The aim was to analyze attitude of health care professionals (HCPs) toward telemedicine, mHealth, and mobile field oncology.We developed conducted online survey with 24 questions evaluating HCPs' general telemedicine patients using apps. Specific on possible functionality for resulting advantages disadvantages both patients' daily clinical routine were evaluated.A total 108 HCPs completed survey....
Implementation of chemotherapy with the drug temozolomide increased overall survival patients glioblastoma multiforme (GBM; WHO grade IV), in particular when O6-methylguanine DNA methyltransferase (MGMT) promoter is epigenetically silenced. Nevertheless, prognosis remains poor, and relapse GBM occurs regularly. This clinical behavior seems to be due existence a therapy-resistant subpopulation cells that induce tumor regrowth. The objective this work was analyze role aldehyde dehydrogenase...
Recent studies suggested that postoperative hypoxia might trigger invasive tumor growth, resulting in diffuse/multifocal recurrence patterns. Aim of this study was to analyze distinct patterns and their association infarct volume outcome. 526 consecutive glioblastoma patients were analyzed, which 129 met our inclusion criteria: initial diagnosis, surgery, diffusion-weighted imaging during follow-up. Distinct contrast-enhancement at diagnosis first (multifocal growth/progression, contact...
Ziel/Aim: Die kürzlich vorgeschlagene, integrierte molekular-morphologische Gradierung von Meningeomen hat sich als genauerer Prädiktor für ein Meningeomrezidiv erwiesen die rein morphologische (WHO) Gradierung. In dieser Studie untersuchten wir erstmals den Zusammenhang des molekular-morphologischen Scores (MMS) mit der Somatostatinrezeptor-(SSR)-Expression in PET.
2001 Background: NOA-04 compared the efficacy and safety of radiotherapy versus (vs)chemotherapy in patients with newly-diagnosed, centrally assessed, supratentorial gliomas WHO grade III had not demonstrated a difference parameters between arms. Here, long-term clinical follow-up for intention-to-treat population (n = 274) biomarker group 207) are presented. Methods: Patients anaplastic astrocytoma (52.6%) oligodendroglial tumors (47.4%) were randomized 2:1:1 (A:B1:B2) to receive 54-60 Gy...
Abstract Background The COVID-19 pandemic poses a huge challenge for clinical teaching due to contact restrictions and social distancing. Medical teachers have balance potential risks benefits of bedside teaching, especially in course formats intended foster practical skills. In this context, we aimed address the question, whether presence-based without patient involvement are suitable teach Methods quasi-experimental study, with were retrospectively compared regarding their effects on...
For about 30 years, researchers developed prognostic scores and searched for factors to predict outcomes cancer patients. The "Combs Prognostic Score" re-irradiation in recurrent glioma was recently validated results showed that the score is a significant (p < .001) reliable predictor patients undergoing (re-RT). We sought enhance generated novel scoring approach, taking into account information on resection of tumors, KPS, tumor volume.The based 209 treated between 2002 2016 at department...
Re-irradiation (Re-RT) is offered widely in clinical routine, and has been established as a key element the treatment of recurrent gliomas. At our center, generally re-resection performed by an experienced neurosurgical team. Thus, Re-RT mostly to patients with macroscopic residuals or irresectable lesions, applied later compared other centers. Therefore, we sought validate Combs Prognostic Score developed 2012 using independent patient cohort.We included 199 treated from 2002 until April...
To evaluate diagnostic accuracy of fully automated analysis multimodal imaging data using [18F]-FET-PET and MRI (including amide proton transfer-weighted (APTw) dynamic-susceptibility-contrast (DSC) perfusion) in differentiation tumor progression from treatment-related changes patients with glioma.At suspected progression, as part a retrospective an observational cohort 66 patients/74 scans (51 glioblastoma 23 lower-grade-glioma, 8 included at two different time points) were automatically...
Despite the availability of various therapy options and being a widely focused research area, prognosis glioblastoma (GBM) still remains very poor due to resistance, genetic heterogeneity diffuse infiltration pattern. The recently described non-apoptotic form cell death ferroptosis may, however, offer novel opportunities for targeted therapies. Hence, aim this study was investigate potential role in GBM, including impact treatment on expression two ferroptosis-associated players...
Although glioblastoma multiforme (GBM) is not an invariably cold tumor, checkpoint inhibition has largely failed in GBM. In order to investigate T cell–intrinsic properties that contribute the resistance of GBM endogenous or therapeutically enhanced adaptive immune responses, we sorted CD4 + and CD8 cells from peripheral blood, normal-appearing brain tissue, tumor bed nine treatment-naive patients with Bulk RNA sequencing highly pure cell populations these different compartments was used...
Abstract Background In neuro-oncology, the inclusion of tumor patients in molecular board has only become increasingly widespread recent years, but so far there are no standards for indication, procedure, evaluation, therapy recommendations and implementation neuro-oncological patients. The present work examines current handling included boards Germany. Methods We created an online based survey with questions covering neuro-oncologic patient inclusion, annotation genetic analyses, management...
Abstract Background Molecular glioblastoma (molGB) does not exhibit the histologic hallmarks of a grade 4 glioma but is nevertheless diagnosed as when harboring specific molecular markers. MolGB can easily be mistaken for similar-appearing lower-grade astrocytomas. Here, we investigated how advanced imaging could reflect underlying tumor biology. Methods Clinical and data were collected 7 molGB 4, 9 astrocytomas 2, 12 3. Four neuroradiologists performed VASARI-scoring conventional imaging,...
The outcome of patients with anaplastic gliomas varies considerably depending on single molecular markers, such as mutations the isocitrate dehydrogenase (IDH) genes, well classifications based epigenetic or genetic profiles. Remarkably, 98% RNA within a cell is not translated into proteins. Of those, especially microRNAs (miRNAs) have been shown only to major influence physiologic processes but also be deregulated and prognostic in malignancies.To find novel survival markers treatment...
Abstract Background H3K27-altered diffuse midline gliomas are uncommon central nervous system tumors with extremely poor prognoses. Case presentation We report the case of a 24-year-old man patient multiple, inter alia osseous metastases who presented back pain, hemi-hypoesthesia, and hemi-hyperhidrosis. The underwent combined radio-chemotherapy demonstrated temporary improvement before deteriorating. Conclusions glioma presents an infrequent but crucial differential diagnosis should be...
Background: The fifth version of the World Health Organization (WHO) classification tumors central nervous system (CNS) in 2021 brought substantial changes. Driven by enhanced implementation molecular characterization, some diagnoses were adapted while others newly introduced. How these changes are reflected imaging features remains scarcely investigated. Materials and Methods: We retrospectively analyzed 226 treatment-naive primary brain tumor patients from our institution who received...