A5000667313- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Heart Rate Variability and Autonomic Control
- Pain Mechanisms and Treatments
- EEG and Brain-Computer Interfaces
- Innovations in Medical Education
- Neural and Behavioral Psychology Studies
- Multiple Sclerosis Research Studies
- Neuroscience and Neuropharmacology Research
- Innovative Teaching Methods
- Stress Responses and Cortisol
- Peripheral Neuropathies and Disorders
- Neuroscience of respiration and sleep
- Pain Management and Placebo Effect
- Migraine and Headache Studies
- Transcranial Magnetic Stimulation Studies
- Musculoskeletal pain and rehabilitation
- Vehicle Routing Optimization Methods
- Tryptophan and brain disorders
- Scheduling and Timetabling Solutions
- Clinical Reasoning and Diagnostic Skills
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Botulinum Toxin and Related Neurological Disorders
- Higher Education Teaching and Evaluation
- Problem and Project Based Learning
Technical University of Munich
2015-2025
Klinikum rechts der Isar
2020-2022
Cognitive Neuroimaging Lab
2019
Universität Hamburg
2013
Abstract Chronic pain is a major health care issue characterized by ongoing and variety of sensory, cognitive, affective abnormalities. The neural basis chronic still not completely understood. Previous work has implicated prefrontal brain areas in pain. Furthermore, neuronal oscillations at gamma frequencies (60–90 Hz) have been shown to reflect the perceived intensity longer lasting experimental healthy human participants. In contrast, noxious stimulus related alpha (8–13 beta (14–29...
Abstract Chronic pain is a common and severely disabling disease whose treatment often unsatisfactory. Insights into the brain mechanisms of chronic promise to advance understanding underlying pathophysiology might help develop markers novel treatments. Here, we systematically exploited potential electroencephalography determine abnormalities function during resting state in pain. To this end, performed state-of-the-art analyses oscillatory activity, connectivity, networks 101 patients...
Pain is considered a frequent symptom in multiple sclerosis. Neuropathic pain the type of most closely related to pathology sclerosis and its prevalence estimates vary largely.We prospectively assessed neuropathic patients with early investigated association other clinical parameters.A total 377 outpatients at an disease stage were included this prospective study. Mean duration was 4.2 years, mean Expanded Disability Status Scale (EDSS) score 1.6, 96.8% classified as having...
Pain is a multidimensional experience, which includes sensory, cognitive, and affective aspects. Converging lines of evidence indicate that dopaminergic neurotransmission plays an important role in human pain perception. However, the precise effects dopamine on different aspects perception remain to be elucidated. To address this question, we experimentally decreased 22 healthy subjects using Acute Phenylalanine Tyrosine Depletion (APTD). During APTD control condition applied brief painful...
Abstract Pain is frequent in multiple sclerosis (MS) and includes different types, with neuropathic pain (NP) being most closely related to MS pathology. However, prevalence estimates vary largely, causal relationships between biopsychosocial factors are largely unknown. Longitudinal studies might help clarify the determinants of MS. To this end, we analyzed data from 410 patients newly diagnosed clinically isolated syndrome or relapsing-remitting participating prospective multicenter German...
Abstract Background The COVID-19 pandemic poses a huge challenge for clinical teaching due to contact restrictions and social distancing. Medical teachers have balance potential risks benefits of bedside teaching, especially in course formats intended foster practical skills. In this context, we aimed address the question, whether presence-based without patient involvement are suitable teach Methods quasi-experimental study, with were retrospectively compared regarding their effects on...
Chronic pain is a prevalent and debilitating condition whose neural mechanisms are incompletely understood. An imbalance of cerebral excitation inhibition (E/I), particularly in the medial prefrontal cortex (mPFC), believed to represent crucial mechanism development maintenance chronic pain. Thus, identifying non-invasive, scalable marker E/I could provide valuable insights into aid developing clinically useful biomarkers. Recently, aperiodic component electroencephalography (EEG) power...
Chronic pain is a highly prevalent and severely disabling disease that associated with substantial changes of brain function. Such have mostly been observed when analyzing static measures resting-state activity. However, activity varies over time, it increasingly recognized the temporal dynamics provide behaviorally relevant information in different neuropsychiatric disorders. Here, we therefore investigated whether function are altered chronic pain. To this end, applied microstate analysis...
Chronic pain is a major healthcare issue posing large burden on individuals and society. Converging lines of evidence indicate that chronic associated with substantial changes brain structure function. However, it remains unclear which neuronal measures relate to clinical parameters over time could thus monitor treatment responses. We therefore performed longitudinal study in we assessed characteristics resting-state electroencephalography data 41 patients before 6 months after...
Chronic pain is a major health care problem. A better mechanistic understanding and new treatment approaches are urgently needed. In the brain, has been associated with neural oscillations at alpha gamma frequencies, which can be targeted using transcranial alternating current stimulation (tACS). Thus, we investigated potential of tACS to modulate pain-related autonomic activity in an experimental model chronic 29 healthy participants. 6 recording sessions, participants completed tonic heat...
Chronic pain is a prevalent and debilitating condition whose neural mechanisms are incompletely understood. An imbalance of cerebral excitation inhibition (E/I), particularly in the medial prefrontal cortex (mPFC), believed to represent crucial mechanism development maintenance chronic pain. Thus, identifying non-invasive, scalable marker E/I could provide valuable insights into aid developing clinically useful biomarkers. Recently, aperiodic component electroencephalography (EEG) power...
Bedside teaching is essential to foster core clinical competences in medical education, especially Neurology. However, bedside skills are declining and new concepts enhance the effectiveness of needed, also view limited in-person possibilities ongoing pandemic situation. If theoretical knowledge taught prior sessions this might allow better focus on practical application aspects during teaching. We thus aimed answer question what extent such an approach can neurological teaching.In...
<h3>Abstract</h3> Pain serves vital protective functions, which crucially depend on appropriate motor responses to noxious stimuli. Such not only but can themselves shape the perception of pain. In chronic pain, is often decoupled from stimuli and are no longer protective, suggests that relationships between stimuli, pain perception, behavior might be changed. We here performed a simple experiment quantitatively assess in 22 patients age-matched healthy human participants. Brief tactile were...
Abstract Chronic pain is a common and severely disabling disease whose treatment often unsatisfactory. Insights into the brain mechanisms of chronic promise to advance understanding underlying pathophysiology might help develop markers novel treatments. Here, we systematically comprehensively exploited potential electroencephalography (EEG) determine abnormalities function during resting state in pain. To this end, performed state-of-the-art analyses oscillatory activity, connectivity...
Autonomic responses are an essential component of pain. They serve its adaptive function by regulating homeostasis and providing resources for protective recuperative to noxious stimuli. To be flexible, autonomic not only determined stimulus characteristics, but likely also shaped perceptual motor However, it is fully known how responses, interact in shaping responses. address this question, we collected perceptual, motor, brief laser stimuli different intensities 47 healthy human...
Resting-state electroencephalography (rsEEG) holds promise as a biomarker of chronic pain. However, the impact centrally acting analgesics like opioids, antiepileptics, and antidepressants on rsEEG remains unclear. This confounds limits interpretability previous studies questions validity candidates We, therefore, aimed to elucidate effects common To this end, we analyzed two large, independent datasets, including 220 people with We performed preregistered multivariate Bayesian analyses...
Chronic pain is a prevalent and debilitating condition whose neural mechanisms are incompletely understood. An imbalance of cerebral excitation inhibition (E/I), particularly in the medial prefrontal cortex (mPFC), believed to represent crucial mechanism development maintenance chronic pain. Thus, identifying non-invasive, scalable marker E/I could provide valuable insights into aid developing clinically useful biomarkers. Recently, aperiodic component electroencephalography (EEG) power...