A5076903309- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- HIV Research and Treatment
- Pharmacological Effects of Natural Compounds
- Toxin Mechanisms and Immunotoxins
- Tryptophan and brain disorders
- Systemic Sclerosis and Related Diseases
- Ion Channels and Receptors
- Pain Mechanisms and Treatments
- Reproductive System and Pregnancy
- Immune Response and Inflammation
- Autoimmune Neurological Disorders and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Herpesvirus Infections and Treatments
- Salivary Gland Disorders and Functions
- Cytomegalovirus and herpesvirus research
- Nerve injury and regeneration
- Systemic Lupus Erythematosus Research
- Pediatric health and respiratory diseases
- Sphingolipid Metabolism and Signaling
- Herbal Medicine Research Studies
- Psychosomatic Disorders and Their Treatments
- Rheumatoid Arthritis Research and Therapies
- Neurogenesis and neuroplasticity mechanisms
St. Josef-Hospital
2015-2021
Ruhr University Bochum
2014-2021
Johannes Gutenberg University Mainz
2020
University Medical Center of the Johannes Gutenberg University Mainz
2020
University of Bern
2020
University Hospital of Bern
2019-2020
Philipps University of Marburg
2020
University of KwaZulu-Natal
2018
University of Lübeck
2018
University Hospital Schleswig-Holstein
2018
Multiple sclerosis (MS) disease risk is associated with reduced sun-exposure. This study assessed the relationship between measures of sun exposure (vitamin D [vitD], latitude) and MS severity in setting two multicenter cohort studies (nNationMS = 946, nBIONAT 990). Additionally, effect-modification by medication photosensitivity-associated MC1R variants was assessed. High serum vitD a score (MSSS), for relapses, lower disability accumulation over time. Low latitude higher vitD, MSSS, fewer...
To assess clinical characteristics, distribution of disease-modifying treatments (DMTs), and neuropsychological symptoms in a large cohort patients with early-stage MS.The German National MS Cohort is multicenter prospective longitudinal study that has recruited DMT-naive clinically isolated syndrome (CIS) relapsing-remitting (RRMS) since 2010. We evaluated their baseline characteristics the prevalence symptoms.Of 1,124 patients, 2.2:1 female-to-male ratio median age at onset 31.71 years...
Abstract Background Only few studies describe the impact of nutritive factors on chronic inflammatory demyelinating polyneuropathy (CIDP), an disease peripheral nervous system. The active component chili pepper, capsaicin, is direct agonist transient receptor potential channel vanilloid subfamily member 1. Its anti-inflammatory effect in animal model experimental autoimmune neuritis (EAN) has been previously demonstrated. Methods In present study, we and anti-oxidative influence capsaicin...
Abstract Pain is frequent in multiple sclerosis (MS) and includes different types, with neuropathic pain (NP) being most closely related to MS pathology. However, prevalence estimates vary largely, causal relationships between biopsychosocial factors are largely unknown. Longitudinal studies might help clarify the determinants of MS. To this end, we analyzed data from 410 patients newly diagnosed clinically isolated syndrome or relapsing-remitting participating prospective multicenter German...
HIV-associated neurocognitive disorders (HAND) affect about 50% of infected patients despite combined antiretroviral therapy (cART). Ongoing compartmentalized inflammation mediated by microglia which are activated HIV-infected monocytes has been postulated to contribute neurotoxicity independent from viral replication. Here, we investigated effects teriflunomide and monomethylfumarate on monocyte/microglial activation neurotoxicity. Human monocytoid cells (U937) transduced with a minimal...
Cognitive impairment (CI) affects approximately one-third of the patients with early multiple sclerosis (MS) and clinically isolated syndrome (CIS). Little is known about factors predicting CI progression after initial diagnosis. Neuropsychological screening data from baseline 1-year follow-up a prospective multicenter cohort study (NationMS) involving 1123 newly diagnosed MS or CIS were analyzed. Employing linear multilevel models, we investigated whether demographic, clinical conventional...
Background Dimethyl fumarate is an immunomodulatory and neuroprotective drug, approved recently for the treatment of relapsing-remitting multiple sclerosis. In view limited therapeutic options human acute chronic polyneuritis, we used animal model experimental autoimmune neuritis in Lewis rat to study effects dimethyl on inflammation neuroprotection peripheral nervous system. Methods Findings Experimental was induced by immunization with neuritogenic peptide (amino acids 53–78) P2 myelin...
Objective Progressive multiple sclerosis is characterized by chronic inflammation with microglial activation, oxidative stress, accumulation of iron and continuous neurodegeneration inadequate effectiveness medications used so far. We now investigated effects on microglia the previously identified neuroprotective antipsychotic clozapine in vitro experimental autoimmune encephalomyelitis (EAE). Methods Microglia were treated followed analysis cell death response to cytokine release neuronal...
Autoimmune neuropathies are common PNS disorders and effective treatment is challenging. Environmental influence dietary components known to affect the course of autoimmune diseases. Capsaicin as pungent component chili-peppers in human nutrition. An capsaicin on diseases has been postulated. We tested animal model experimental neuritis (EAN) Lewis rat. Rats were immunized with P2-peptide treated different preventive settings. Electrophysiological, histological, molecular biological analyses...
Fingolimod, a sphingosine-1-phosphate receptor modulator with well-described immunomodulatory properties involving peripheral immune cell trafficking, was the first oral agent approved for treatment of relapsing remitting multiple sclerosis. Analogous options chronic autoimmune neuropathies are lacking. We tested fingolimod in animal model experimental neuritis Lewis rat. Six to eight-week-old female rats were immunized P2 peptide and from this day on treated fingolimod. Histology sciatic...
Corticosteroids dominate in the treatment of chronic autoimmune neuropathies although long-term use is characterized by devastating side effects.We introduce intrathecal application synthetic steroid triamcinolone (TRIAM) as a novel therapeutic option experimental neuritis Lewis rats RESULTS: After immunization with neuritogenic P2 peptide, we show dose-dependent effect one injection 0.3 or 0.6 mg/kg TRIAM on clinical and electrophysiological parameters lower degree inflammatory infiltrates...
To assess the impact of APOE polymorphisms on cognitive performance in patients newly diagnosed with clinically isolated syndrome (CIS) or relapsing-remitting MS (RRMS).This multicenter cohort study included 552 untreated recently CIS RRMS according to 2005 revised McDonald criteria. The single nucleotide rs429358 (ε4) and rs7412 (ε2) haplotype were assessed by allelic discrimination assays. Cognitive was evaluated using 3-second paced auditory serial addition test Multiple Sclerosis...
Abstract Several neuroimmunological registries have been established in Germany during the last 10 years. The common aim is to investigate course of different diseases, mainly under various therapeutic conditions, identify predictive factors as well side effects immunomodulating therapies. Six nationwide will be presented this article. German Network for Research on Autoimmune Encephalitis (GENERATE) with more than 40 participating clinical centers and 570 documented patients (September...
Zusammenfassung In den letzten 10 Jahren wurden in Deutschland mehrere neuroimmunologische Register aufgebaut. Grundlegendes Ziel ist es, mehr über Verlauf der entsprechenden Erkrankung, insbesondere unter therapeutischen Bedingungen, oder auch Nebenwirkungen eingesetzter Immuntherapeutika zu erfahren, im besten Fall prädiktive Marker identifizieren. Sechs dieser möchten wir folgenden Artikel vorstellen. Das Deutsche Netzwerk zur Erforschung autoimmuner Enzephalitiden (GENERATE) mit als 40...
We used the animal model of experimental autoimmune neuritis (EAN) in Lewis rat to study effects dimethyl fumarate (DMF) on intestinal immune regulation.
Objective To investigate whether inflammatory changes and markers of neurodegeneration occur in CSF HIV-infected patients already prior to neurocognitive symptoms. Background Prevalence especially milder forms HIV-associated disorders (HAND) is high despite profound efficacy highly active antiretroviral therapy. Reliable biomarkers defining at risk are lacking. Methods Cerebrospinal fluid HIV+ without neuropsychological impairment (n=45) controls with non-inflammatory neurological (NIND,...
OBJECTIVE:We investigated the neuroprotective effect of laquinimod (LQ) in experimental autoimmune neuritis (EAN), a rat model acute peripheral polyneuritis (Guillain-Barre Syndrome). BACKGROUND:LQ is an orally administered, active immunomodulator with potential phase 3 studies for patients multiple sclerosis. It induces overexpression brain-derived neurotrophic factor (BDNF) cortex mice encephalomyelitis (EAE), sclerosis. DESIGN/METHODS:Active EAN was induced by immunization peptide aa...