An individual’s expectation that a pain treatment will or not work can alter both its subjective effectiveness and the pain-related activity in brain.

The decision as to whether a sensation is perceived painful does not only depend on sensory input but also the significance of stimulus. Here, we show that degree which an impending stimulus interpreted threatening biases perceptual decisions about pain and this bias toward manifests before encounter. Using functional magnetic resonance imaging investigated neural mechanisms underlying influence experimental manipulation threat perception laser stimuli painful. In near-threshold detection...

Successful behavior requires selection and preferred processing of relevant sensory information. The cortical representation information has been related to neuronal oscillations in the gamma frequency band. Pain is invariably high behavioral relevance and, thus, nociceptive stimuli receive processing. Here, by using magnetoencephalography, we show that selective induce between 60 95 Hz primary somatosensory cortex. Amplitudes pain-induced vary with objective stimulus intensity subjective...

Pain is a highly subjective experience that can be substantially influenced by differences in individual susceptibility as well personality. How to pain and personality translate brain activity largely unknown. Here, we report the functional connectivity of two key areas before sensory event reflects subsequent noxious stimulus being perceived painful. Specifically, prestimulus among related perception body modulation (anterior insular cortex brainstem, respectively) determines whether...

Under physiological conditions, momentary pain serves vital protective functions. Ongoing in chronic states, on the other hand, is a pathological condition that causes widespread suffering and whose treatment remains unsatisfactory. The brain mechanisms of ongoing are largely unknown. In this study, we applied tonic painful heat stimuli varying degree to healthy human subjects, obtained continuous ratings, recorded electroencephalograms relate activity. Our results reveal subjective...

Parallel activation of primary and secondary somatosensory cortices in human pain processing. Cerebral processing has been shown to involve (SI) (SII) cortices. However, the temporal pattern these nociceptive not demonstrated so far. We therefore used whole-head magnetoencephalography record cortical responses cutaneous laser stimuli six healthy subjects. By using selective our results confirm involvement contralateral SI bilateral SII Beyond they show for first time simultaneous onset after...

The primary (SI) and secondary (SII) somatosensory cortices have been shown to participate in human pain processing. However, humans it is unclear how SI SII contribute the encoding of nociceptive stimulus intensity. Using magnetoencephalography (MEG) we recorded responses eight healthy four different intensities selectively laser stimuli delivered dorsum right hand. Subjects' ratings correlated highly with applied Activation contralateral bilateral showed a significant positive correlation...

We report findings from clinical examination and cutaneous laser stimulation in a 57-year-old male, who suffered right-sided postcentral stroke. In this patient, we were able to demonstrate (i) dissociation of discriminative affective components pain perception and, for the first time humans, (ii) dependence sensory-discriminative component sensation on integrity lateral system.

Processing of tactile stimuli within somatosensory cortices has been shown to be complex and hierarchically organized. However, the precise organization nociceptive processing these remained largely unknown. We used whole-head magnetoencephalography directly compare cortical responses stimulation afferents dorsum hand in humans. Within primary cortex (SI), activated a single source whereas two sequentially peaking sources. Along postcentral gyrus, SI was located 10 mm more medially than...

Single painful stimuli evoke two successive and qualitatively distinct sensations referred to as first second pain sensation. Peripherally, the neural basis of this phenomenon is a dual pathway for with Adelta C fibers mediating pain, respectively. Yet, differential cortical correlates both are largely unknown. We therefore used magnetoencephalography record directly compare pain-related responses cutaneous laser in humans. Our results show that brief sustained activity corresponding...

Pain is known to comprise sensory, cognitive, and affective aspects. Despite numerous previous fMRI studies, however, it remains open which spatial distribution of activity sufficient encode whether a stimulus perceived as painful or not. In this study, we analyzed data from perceptual decision-making task in participants were exposed near-threshold laser pulses. Using multivariate analyses on different scales, investigated the predictive capacity for decoding had been painful. Our analysis...

The perception of pain is characterized by its tremendous intra- and interindividual variability. Different individuals perceive the very same painful event largely differently. Here, we aimed to predict individual sensitivity from brain activity. We repeatedly applied identical stimuli healthy human subjects recorded activity using electroencephalography (EEG). a multivariate pattern analysis time-frequency transformed single-trial EEG responses. Our results show that classifier trained on...

Cannabis is reported to be remarkably effective for the relief of otherwise intractable pain. However, bases pain afforded by this psychotropic agent are debatable. Nonetheless, frontal-limbic distribution cannabinoid receptors in brain suggests that cannabis may target preferentially affective qualities This central mechanism action relevant analgesia humans, but has yet demonstrated. Here, we employed functional magnetic resonance imaging investigate effects delta-9-tetrahydrocannabinol...

Abstract Chronic pain is a major health care issue characterized by ongoing and variety of sensory, cognitive, affective abnormalities. The neural basis chronic still not completely understood. Previous work has implicated prefrontal brain areas in pain. Furthermore, neuronal oscillations at gamma frequencies (60–90 Hz) have been shown to reflect the perceived intensity longer lasting experimental healthy human participants. In contrast, noxious stimulus related alpha (8–13 beta (14–29...

Significance Noninvasive brain imaging of humans identifies prominent networks related to sensory and cognitive functions in the resting state; however, signaling hierarchy directionality among these remain largely unknown. Integrating simultaneously recorded measures for network identification regional energy metabolism, we propose metabolic connectivity mapping (MCM) as a novel measure reveal human brain. Comparing simple “eyes closed” open” conditions healthy subjects, MCM revealed stable...

Noxious stimuli induce physiological processes which commonly translate into pain. However, under certain conditions, pain intensity can substantially dissociate from stimulus intensity, e.g. during longer-lasting in chronic syndromes. How and are differentially represented the human brain is, however, not yet fully understood. We therefore used electroencephalography (EEG) to investigate cerebral representation of noxious 10 min painful heat stimulation 39 healthy participants. Time courses...

Abstract Chronic pain is a common and severely disabling disease whose treatment often unsatisfactory. Insights into the brain mechanisms of chronic promise to advance understanding underlying pathophysiology might help develop markers novel treatments. Here, we systematically exploited potential electroencephalography determine abnormalities function during resting state in pain. To this end, performed state-of-the-art analyses oscillatory activity, connectivity, networks 101 patients...

Biomarker discovery in neurological and psychiatric disorders critically depends on reproducible transparent methods applied to large-scale datasets. Electroencephalography (EEG) is a promising tool for identifying biomarkers. However, recording, preprocessing, analysis of EEG data time-consuming researcher-dependent. Therefore, we developed DISCOVER-EEG, an open fully automated pipeline that enables easy fast analysis, visualization resting state data. Data the Brain Imaging Structure...