A5060302677- Bladder and Urothelial Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Urinary and Genital Oncology Studies
- Prostate Cancer Diagnosis and Treatment
- Urological Disorders and Treatments
- Urinary Bladder and Prostate Research
- Colorectal Cancer Screening and Detection
- Prostate Cancer Treatment and Research
- Urologic and reproductive health conditions
- Sperm and Testicular Function
- Inflammatory Bowel Disease
- Pelvic floor disorders treatments
- Diversity and Career in Medicine
- Healthcare Policy and Management
- T-cell and B-cell Immunology
- Microscopic Colitis
- Cancer, Lipids, and Metabolism
- Human-Animal Interaction Studies
- Health and Medical Research Impacts
- Genetic Associations and Epidemiology
- Urinary Tract Infections Management
- Hormonal and reproductive studies
- Cancer Genomics and Diagnostics
- Genital Health and Disease
- Innovations in Medical Education
Carolina Urologic Research Center
2024-2025
Northwestern University
2018-2023
Northwestern University
2021
Virginia Commonwealth University
2015-2020
The University of Texas Southwestern Medical Center
2017
Abstract Checkpoint immunotherapy (CPI) has increased survival for some patients with advanced-stage bladder cancer (BCa). However, most do not respond. Here, we characterized the tumor and immune microenvironment in pre- post-treatment tumors from PURE01 neoadjuvant pembrolizumab trial, using a consolidative approach that combined transcriptional genetic profiling digital spatial profiling. We identify five distinctive transcriptomic programs validate these an independent CPI trial to...
Intravenous immune checkpoint inhibition is an effective anticancer strategy for bacillus Calmette-Guérin (BCG)-unresponsive non-muscle-invasive bladder cancer (NMIBC) but may be associated with greater systemic toxicity compared localized therapies.We assessed the safety and antitumor activity of intravesical pembrolizumab combined BCG.A 3 + phase 1 trial BCG was conducted in patients BCG-unresponsive NMIBC (NCT02808143).Pembrolizumab given intravesically (1-5 mg/kg 2 h) beginning weeks...
Abstract The proper regulation of ICOS and ligand (ICOSL) has been shown to be essential for maintaining immune homeostasis. Loss either protein results in defective humoral immunity, overexpression aberrant Ab production resembling lupus. How ICOSL is regulated response interaction still unclear. We demonstrate that a disintegrin metalloproteinase (ADAM)10 the primary physiological sheddase mice humans. Using an vivo system which ADAM10 deleted only on B cells, elevated levels were seen....
Abstract Inflammatory bowel disease (IBD) is an established risk factor for colorectal cancer. Recent reports suggesting IBD also a prostate cancer (PC) require further investigation. We studied 218 084 men in the population‐based UK Biobank cohort, aged 40 to 69 at study entry between 2006 and 2010, with follow‐up through mid‐2015. assessed association subsequent PC using multivariable Cox regression analyses, adjusting age assessment, ethnic group, region, smoking status, alcohol drinking...
Men diagnosed with low-risk prostate cancer (PC) are increasingly electing active surveillance (AS) as their initial management strategy. While this may reduce the side effects of treatment for cancer, many men on AS eventually convert to treatment. PC is one most heritable cancers, and genetic factors that predispose aggressive tumors help distinguish who more likely discontinue AS. To investigate this, we undertook a multi-institutional genome-wide association study (GWAS) 5,222 patients...
Abstract Sperm associated antigen 6 (SPAG6), a component of the central apparatus “9 + 2” axoneme, plays role in ciliary and flagellar motility; but, its contribution to adaptive immunity immune system development is completely unknown. While cells lack cilium, immunological synapse surrogate cilium as it utilizes same machinery ciliogenesis including nucleation microtubules at centrosome. This prompted our hypothesis that SPAG6 critically regulates formation function synapses. Using bone...
No AccessJournal of UrologyAdult Urology1 Nov 2021Factors Associated with Time to Conversion from Active Surveillance Treatment for Prostate Cancer in a Multi-Institutional CohortThis article is commented on by the following:Editorial Comment Lauren Folgosa Cooley, Adaeze A. Emeka, Travis J. Meyers, Phillip R. Cooper, Daniel W. Lin, Antonio Finelli, James Eastham, Christopher Logothetis, Leonard S. Marks, Danny Vesprini, Larry Goldenberg, Celestia Higano, Christian P. Pavlovich, June M....
ADAM10, as the sheddase of low affinity IgE receptor (CD23), promotes production and thus is a unique target for attenuating allergic disease. Herein, we describe that B cell levels specifically, are increased in patients Th2 prone WT mouse strains (Balb/c A/J). While T help augments ADAM10 expression, Balb cells exhibit naïve state even more dramatically after anti-CD40/IL4 stimulation compared C57 (Th1 prone) cells. Furthermore, ADAM17 TNF reduced A/J) to Th1 controls. To further...
Abstract Men diagnosed with low-risk prostate cancer (PC) are increasingly electing active surveillance (AS) as their initial management strategy. While this may reduce the side effects of treatment for cancer, many men on AS eventually convert to treatment. PC is one most heritable cancers, and genetic factors that predispose aggressive tumors help distinguish who more likely discontinue AS. To investigate this, we undertook a multi-institutional genome-wide association study (GWAS) 6,361...
Abstract Animal assisted interventions (AAI) have been shown to improve patient outcomes in some healthcare settings. Flexible cystoscopy, while minimally invasive, is associated with patient-reported pain, fear, and anxiety. Few techniques found these adverse effects cystoscopy. The purpose of this study was extend existing research on AAI outpatient settings investigate the effectiveness reducing distress Ninety-five patients (average age 55.5 years) were prospectively enrolled randomized...
The treatment landscape for metastatic hormone-sensitive prostate cancer (mHSPC) has dramatically evolved. Monotherapy androgen deprivation therapy (ADT) with testosterone suppression alone is no longer the standard of care as multiple global phase 3 trials different combinatorial strategies have been clinically and statistically successful combinations incorporated into guidelines on advanced cancer. For appropriate patients, clinicians should consider combining ADT docetaxel or an receptor...
Abstract Background Adult men with autoimmune conditions are commonly prescribed anti-tumor necrosis factor (anti-TNF) agents; however, there is a paucity of quality evidence as to their effect on male fertility (e.g. semen parameters and sperm quality). Our objective was determine if being counseled regarding the unknown reproductive effects anti-TNF agents prior initiation therapy. Methods A retrospective analysis 1010 patients age 18–45 who were an agent assessed for (1) receipt...
BACKGROUND: There is insufficient data to recommend screening for bladder cancer (BC). For future BC trials, it important understand how and if tumor (T) stage can act as a surrogate outcome marker overall (OS) cancer-specific (CSS) survival. OBJECTIVE: To characterize OS CSS between primary stages in non-metastatic (BC) patients. METHODS: Non-metastatic patients were identified the National Cancer Database (NCDB; 2004-2015) (n = 343,163) Institute Surveillance, Epidemiology, End Results...
Introduction: Holmium laser enucleation of the prostate (HoLEP) is a size-independent treatment option for management benign prostatic hypertrophy. Although advancements in technology have led to clinical improvements portion HoLEP, morcellation aspect HoLEP often rate-limiting step. We sought compare efficiency and surgeon satisfaction four commercial morcellators. Methods: This was an ex vivo study comparing morcellators: Wolf Piranha™, Lumenis VersaCut™, JenaSurgical MultiCut Solo™, Hawk™...