A5103028802- Hearing Loss and Rehabilitation
- Hearing, Cochlea, Tinnitus, Genetics
- Mobile Health and mHealth Applications
- Folate and B Vitamins Research
- Lipoproteins and Cardiovascular Health
- Nutrition and Health in Aging
- Cardiovascular Health and Risk Factors
- Dementia and Cognitive Impairment Research
- Attachment and Relationship Dynamics
- Neuroendocrine regulation and behavior
- Alzheimer's disease research and treatments
- Infant Health and Development
- Bariatric Surgery and Outcomes
- Diet and metabolism studies
- Nutritional Studies and Diet
- Retinal Imaging and Analysis
- Medication Adherence and Compliance
- Religious Studies and Spiritual Practices
- Pharmaceutical Practices and Patient Outcomes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Gastric Cancer Management and Outcomes
- Language, Linguistics, Cultural Analysis
- Noise Effects and Management
- Blood Pressure and Hypertension Studies
- Retinal Diseases and Treatments
University of California, San Francisco
2015-2025
Northern California Institute for Research and Education
2020
San Francisco VA Health Care System
2020
Kaiser Permanente
2020
Universidad Rey Juan Carlos
2020
23andMe (United States)
2020
University of California, Davis
2020
Abstract INTRODUCTION We evaluated the independent associations between high‐density lipoprotein cholesterol (HDL‐C) and triglyceride (TG) levels with Alzheimer's disease related dementias (ADRD). METHODS Among 177,680 members of Kaiser Permanente Northern California who completed a survey on health risks, we residualized TGs HDL‐C conditional age, sex, body mass index. included these residuals individually concurrently in Cox models predicting ADRD incidence. RESULTS Low (hazard ratio [HR]...
Importance Vision and eye conditions are associated with increased risk for Alzheimer disease related dementias (ADRDs), but the nature of association underlying biological pathways remain unclear. If causal, vision would be an important modifiable factor viable population-level interventions. Objective To evaluate potentially causal associations between visual acuity, (specifically cataracts myopia), neuroimaging outcomes, ADRDs. Design, Setting, Participants A cohort 2-sample bidirectional...
Abstract INTRODUCTION Mixed evidence on how statin use affects risk of Alzheimer's disease and related dementias (ADRD) may reflect heterogeneity across sociodemographic factors. Few studies have sufficient power to evaluate effect modifiers. METHODS Kaiser Permanente Northern California (KPNC) members ( n = 705,061; 202,937 with surveys) who initiated statins from 2001 2010 were matched age low‐density lipoprotein cholesterol (LDL‐C) non‐initiators followed through 2020 for incident ADRD....
Abstract INTRODUCTION Decreases in body mass index (BMI) may be early consequences of Alzheimer's disease (AD) pathophysiological changes. Previous research the UK Biobank estimated that AD‐related genes began affecting BMI around age 47. We assessed whether this result could replicated using longitudinal data an independent cohort. METHODS Using All Us (AOU) ( N = 197,619, aged 30+) data, we linear mixed models for associations Z ‐scored AD‐Genetic Risk Score (AD‐GRS) with BMI, stratified...
<h3>Objective</h3> To test the hypothesis that incipient Alzheimer disease (AD) may adversely affect hearing and loss cognition, we evaluated whether genetic variants increase AD risk also problem impairment do not influence cognition. <h3>Methods</h3> UK Biobank participants without dementia ≥56 years of age with Caucasian ancestry completed a Digit Triplets Test speech-in-noise (n = 80,074), self-reported background noise 244,915), brief cognitive assessments. A score for (AD-GRS) was...
Theory of mind (ToM) is the ability to interpret and understand human behaviour by representing mental states others. Like many capacities, ToM thought develop through both complex biological socialization mechanisms. However, no study has examined joint effect genetic environmental influences on ToM. This how variability in oxytocin receptor gene ( OXTR ) parenting behaviour—two widely studied factors development—interacted predict pre-school-aged children. Participants were 301 children...
Introduction: Polygenic risk scores (PRS) provide a summation of small-effect genetic variants that predict cardiovascular (CV) disease risk. Socioeconomic status (SES) can also impact CV risk, but it is unknown whether SES modifies the effects PRS on events. Hypothesis: The association between and events modified by SES. Methods: Participants without at baseline from UK Biobank prospective cohort study were followed recruitment (2006-2010) through 2023. We included participants with data...
Background: Despite adherence to antiplatelet medications being critical prevent stent thrombosis and subsequent life-threatening complications, rates of long-term non-adherence range from 21-57%. Text messaging (TM) mobile applications (apps) are practical inexpensive strategies potentially promote medication adherence. Objective: The Mobile4Meds study sought determine whether TM or a app for adherence, compared control, improved use among patients who experienced acute coronary syndrome...
Background: Adherence to cardiovascular medications is critical for avoid morbidity and mortality may influence mental health. The use of text messaging (TM) or mobile applications (apps) medication adherence be supportive health in patients with disease (CVD). Objective: This study sought compare self-reported (symptoms depression, anxiety, post-traumatic stress disorder) participants a 3-arm randomized clinical trial (RCT): 1) TM, 2) app, 3) control groups. primary goal the parent was...
Abstract Context Roux-en-Y gastric bypass (RYGB) has deleterious effects on bone mass, microarchitecture, and strength. The skeletal of sleeve gastrectomy (SG), now the most commonly performed bariatric surgical procedure, are incompletely understood. Objective We examined changes in turnover, areal volumetric mineral density (aBMD, vBMD), appendicular microarchitecture estimated strength after SG. compared results to those previously reported RYGB, hypothesizing lesser SG than RYGB. Design,...
Breast cancer prevalence has increased globally, with 12.2% of breast cases identified in China. Obesity and unhealthy lifestyles are major risk factors for cancer. We conducted a randomized control trial to assess the feasibility evaluate preliminary effect Smartphone-Based Cancer Prevention Education (SCOPE) program among adult biological women waist circumference greater than 80 cm. The SCOPE includes tailored culturally appropriate educational information obesity prevention delivered by...
Abstract Background Age‐related hearing impairment is associated with elevated Alzheimer’s disease (AD) and dementia risk. The ‐ association may be due to underlying AD‐related neurodegeneration or shared risk factors that influence loss (e.g. reverse causation confounding). This difficult assess in traditional observational studies; we used genetic for AD as an analytic tool explore the extent which also influences functional loss. Method We studied 401,084 UK Biobank participants aged...
Abstract Introduction Incipient dementia or shared genetics may partly explain the association between hearing loss and dementia. We evaluated whether genetic variants known to increase Alzheimer’s disease (AD) also influence difficulty. Methods UK Biobank participants aged 56+ with Caucasian ancestry self-reported difficulty background noise (n=244,915) underwent objectively measured assessments (n=80,074). Poor objective was defined as >-5.5 dB speech reception threshold on a Digit...
Abstract Objectives Weight loss is common in the years before an Alzheimer’s disease (AD) diagnosis, likely due to changes appetite and diet. The age at which this change body mass index (BMI) emerges unclear but may point earliest manifestations of AD, timing that be important for identifying windows intervention or risk reduction. We examined association between AD genetic cross-sectional BMI across adults mid-to late-life as innovative approach determine indicate preclinical AD. Design...
Age-related hearing impairment is hypothesized as a major modifiable risk factor for dementia, with population attributable of 9%. However, the association between and dementia may be due to reverse causation through neurodegeneration or other shared biological mechanisms. If such associations, genetic factors are likely concurrently influence loss in older adults. We studied UK Biobank participants who were aged 55+, Caucasian ancestry, enrolled 2007 - 2010. Participants (n=236,146)...
Higher midlife Body Mass Index (BMI) may be a risk factor for Alzheimer's disease (AD). However, weight loss is common in the years before AD diagnosis likely due to appetite changes and worse nutrition. The age at which this change BMI emerges unclear but point earliest manifestations of target prevention. We examined association between genetic across mid late-life as an innovative approach determine indicate preclinical AD. studied 407,386 UK Biobank non-demented participants aged 39–73...
Abstract Underlying AD-related neurodegeneration or shared risk factors may influence hearing loss; in an innovative approach we tested whether genetic for AD also influences functional loss. We studied 401,084 UK Biobank participants aged 40-70, with Caucasian ancestry, and enrolled 2007-2010. Participants self-reported difficulty were followed diagnosis until 2018. A score (AD-GRS) was calculated as a weighted sum of 23 variants. In age-, sex-, ancestry- adjusted models higher AD-GRS...
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