A5054206729- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Neurological diseases and metabolism
- Lysosomal Storage Disorders Research
- Autism Spectrum Disorder Research
- RNA regulation and disease
- Nuclear Receptors and Signaling
- Sleep and related disorders
- Acute Ischemic Stroke Management
- Carbohydrate Chemistry and Synthesis
- Genetic Associations and Epidemiology
- Restless Legs Syndrome Research
- Health Systems, Economic Evaluations, Quality of Life
- Neuroscience of respiration and sleep
- Obstructive Sleep Apnea Research
- Diphtheria, Corynebacterium, and Tetanus
- Mitochondrial Function and Pathology
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- HIV-related health complications and treatments
- HIV Research and Treatment
- Mobile Health and mHealth Applications
- Alzheimer's disease research and treatments
- Birth, Development, and Health
University of Lagos
2015-2025
Lagos University Teaching Hospital
2011-2024
Adeleke University
2022
The Neurological Institute
2015
Cleveland Clinic
2015
Federal Medical Centre
2011
Current data on the pattern of parkinsonism and Parkinson's disease in Nigerians are sparse.This database was designed to document clinical profile PD Nigerians, compare this prior observations.A patients presenting Neurology out-patients clinic Lagos University Teaching Hospital established October 1996. Demographic at presentation (disease stage using Hoehn Yahr scale; 'off' state severity Unified Rating Scale) were documented for diagnosed with between 1996 December 2006. Cases classified...
Hypertension is the major risk factor for cardiovascular diseases and prevalence rates are critical to understanding burden envisaging health service requirements resource allocation. We aimed provide an update of current hypertension blood pressure profiles adults in urban Nigeria.Cross sectional population-based survey Lagos, Nigeria. Participants were selected using stratified multistage sampling. Relevant sections World Health Organization STEPwise approach chronic disease surveillance...
Symptom scores show that a significant proportion of Nigerians are at high risk developing obstructive sleep apnea; however, the diagnosis is rarely made in this country. The knowledge medical students regarding apnea may provide insight into their future ability to recognize patients with and can also inform student education on disease.To assess attitudes graduating Nigeria using standard validated questionnaire.This descriptive, cross-sectional survey study was performed College Medicine...
Adverse cardiovascular outcomes are linked to higher burden of obesity and hypertension. We conducted a secondary analysis data for 5135 participants aged ≥ 16 years from our community-based hypertension prevalence study determine the association between multiple anthropometric indices blood pressure (BP). The were waist circumference (WC), body mass index (BMI), waist-to-height ratio (WHtR), waist-to-hip (WHR), shape index(ABSI), abdominal volume (AVI), adiposity (BAI), roundness (BRI),...
Parkinson disease (PD) is associated with a high prevalence of insomnia, affecting up to 88% patients. Pharmacotherapy studies in the literature addressing insomnia PD reveal disappointing and inconsistent results. Cognitive behavioral therapy (CBT) novel treatment option durable effects shown primary insomnia. However, lack accessibility expense can be limiting. For these reasons, computerized CBT for (CCBT-I) has been developed. The CCBT-I program 6-week web-based course consisting daily...
Abstract Background Rapid eye movement (REM) sleep behavior disorder (RBD) is an early feature of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Damaging coding variants in Glucocerebrosidase ( GBA1 ) are a genetic risk factor for RBD. Recently, population‐specific non‐coding variant (rs3115534) was found to be associated PD earlier onset individuals African ancestry. Objectives We aimed investigate whether the rs3115534 RBD persons PD. Methods studied 709 776 neurologically...
Objective: Cardiac dysfunction is rarely diagnosed in HIV-infected children our setting and standard care does not include baseline follow-up echocardiography. We aimed to determine the prevalence, pattern predictors of HIV-related cardiac dysfunction. Methods: Pre-diagnosed aged 18 months 12 years from a tertiary teaching hospital Lagos, South-West Nigeria were enrolled comparative, observational cross-sectional study; matched with apparently healthy controls same age group, recruited...
Introduction. HIV-associated neurocognitive disorder (HAND) remains common despite the availability of antiretroviral therapy. Routine screening will improve early detections. Objective. To compare performance minimental state examination (MMSE) and international HIV dementia scale (IHDS) in assessing function HIV/AIDS patients on Methods. A case-control study 208 HIV-positive 121 HIV-negative individuals. Baseline demographic data were documented cognitive assessed using two instruments....
ABSTRACT Background Fatigue affects 40% to 50% of all PD patients and is a leading cause disability, with no clearly established or efficacious treatments. Methods In this double‐blinded, placebo‐controlled, pilot trial, we investigated whether rasagiline improved fatigue among patients. Subjects were randomized 1 mg daily placebo for 12 weeks. The primary endpoint was change in the Modified Impact Scale from baseline week 12. Results Thirty subjects (16 men), score 67 ± 15, vs. 14 placebo)....
Understanding the genetic mechanisms underlying diseases in ancestrally diverse populations is a critical step towards realization of global application precision medicine. The African and admixed enable mapping complex traits given their greater levels diversity, extensive population substructure, distinct linkage disequilibrium patterns.Here we perform comprehensive genome-wide assessment Parkinson's disease (PD) 197,918 individuals (1,488 cases; 196,430 controls) ancestry, characterizing...
Primary headaches are underdiagnosed and undertreated, with a significant impact on social activities work.To determine the last-year prevalence health care utilization pattern of primary at tertiary centre.A cross-sectional study was carried out amongst staff Lagos State University Teaching Hospital in Lagos, Nigeria. 402 members were selected by simple random sampling administered detailed structured headache assessment questionnaire. Migraine tension-type diagnosed according to criteria...
Limited access to medicines can impact negatively on outcomes in people with Parkinson's disease (PD). The study objectives were determine the availability and assess affordability of antiparkinsonian medications pharmacies across Nigeria.This was a cross-sectional nationwide utilizing World Health Organization/Health Action Initiative methodology. Strategically selected private- public-sector six geopolitical zones Nigeria surveyed for management early advanced PD. nine categories were:...
Abstract Background Parkinson’s disease (PD) is the second most common neurodegenerative disorder and, according to Global Burden of Disease estimates in 2015, was fastest growing neurological globally with respect associated prevalence, disability, and deaths. Information regarding awareness, diagnosis, phenotypic characteristics, epidemiology, risk factors, treatment, economic impact lived experiences people PD from African perspective relatively sparse contrast developed world, much...
Clinical disease registries are useful for quality improvement in care, benchmarking standards, and facilitating research. Collaborative networks established thence can enhance national international studies by generating more robust samples credible data promote knowledge sharing capacity building. This report describes the methodology, baseline data, prospects of Nigeria Parkinson Disease Registry.This registry was November 2016. Ethics approval obtained all sites. Basic anonymized...
Abstract Background Africans are underrepresented in Huntington's disease (HD) research. A European ancestor was postulated to have introduced the mutant Huntingtin ( mHtt ) gene continent; however, recent work has shown existence of a unique Htt haplotype South‐Africa specific indigenous Africans. Objective We aimed investigate CAG trinucleotide repeats expansion geographically diverse cohort patients with chorea and unaffected controls from sub‐Saharan Africa. Methods evaluated 99...
Background. Sensory neuropathy (SN) is one of the most common AIDS-associated neurologic disorders especially in era highly active antiretroviral therapy (HAART). The aim this study was to determine prevalence SN among highly-active-antiretroviral-therapy- (HAART-) experienced and HAART-naïve HIV-positive individuals investigate relationship demographic, clinical, laboratory factors. Methods. 323 patients with HIV infection (142 on HAART 181 naïve) were enrolled a cross-sectional screening...
Background: There is evidence of an association between mediators inflammation, particularly C-reactive protein (CRP), and outcome acute ischaemic stroke. This provides a potential opportunity for interventions aimed at improving outcome. sparse data exploring the role inflammatory markers such as CRP stroke in Africans. The study objective was to determine admission serum levels short-term Nigerian patient presenting with stroke.Materials Methods: Consecutive patients hospitalized...
The impact of Obstructive sleep apnea (OSA) in worsening outcomes is profound, especially the presence comorbid conditions. This study aimed to describe proportion patients at a high risk OSA our practice setting.The STOP BANG questionnaire and Epworth Sleepiness scale were used assess for excessive daytime sleepiness respectively. Hospitalized out-patients recruited. Intergroup differences continuous variables compared using analysis variance. with was presented as frequencies group Pearson...
To date the LRRK2 p.G2019S mutation remains most common genetic cause of Parkinson disease (PD) worldwide. It accounts for up to 6% familial and approximately 1.5% sporadic cases. has a kinase enzymatic domain which provides an attractive potential target drug therapies inhibitors are in development. Prevalence variable ethnic geographic distribution, highest reported among Ashkenazi Jews (30% patients with PD, 14% 2.0% controls) North African Berbers (37% 41% 1% controls). Little is known...
Telemedicine has reinforced its position as a means for the continuity of healthcare services and cost-effective approach to improving health equity demonstrated during COVID-19 pandemic. The preparedness systems telemedicine is an indicator scalability their services, especially catastrophes. We aimed assess maturity federally funded tertiary institutions in Nigeria, deploy such data are currently lacking required drive improvements delivery.We conducted cross-sectional survey thirty...
There is a paucity of information on utilisation emergency medical services in Nigeria. This study was conducted to determine the pattern respiratory diseases seen among adults an room(ER) and their mortality within twenty- four hours health facility Nigeria.We carried out retrospective adult patients that presented with condition from November 2004 December 2010 at room Federal Medical Centre Ido-Ekiti, south western, Nigeria.A total 3671 cases were seen, 368 accounting for 10.2 %...