Uchechi Agulanna

ORCID: 0000-0002-0145-7833
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About
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Research Areas
  • Parkinson's Disease Mechanisms and Treatments
  • RNA regulation and disease
  • Nuclear Receptors and Signaling
  • Lysosomal Storage Disorders Research
  • Neurological disorders and treatments
  • Botulinum Toxin and Related Neurological Disorders
  • Autism Spectrum Disorder Research
  • Restless Legs Syndrome Research
  • Studies on Chitinases and Chitosanases

Lagos University Teaching Hospital
2021-2023

University of Lagos
2023

Understanding the genetic mechanisms underlying diseases in ancestrally diverse populations is a critical step towards realization of global application precision medicine. The African and admixed enable mapping complex traits given their greater levels diversity, extensive population substructure, distinct linkage disequilibrium patterns.Here we perform comprehensive genome-wide assessment Parkinson's disease (PD) 197,918 individuals (1,488 cases; 196,430 controls) ancestry, characterizing...

10.1101/2023.05.05.23289529 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2023-05-07

Abstract The relationship between APOE polymorphisms and Parkinson’s disease (PD) in black Africans has not been previously investigated. We evaluated the association polymorphic variability self-declared cognition 1100 Nigerians with PD 1097 age-matched healthy controls. Cognition was assessed using single item question (item 1.1) of MDS-UPDRS. genotype allele frequencies did differ controls ( p > 0.05). No allelic or genotypic observed age at onset PD. In PD, ε 4/ 4 conferred a two-fold...

10.1038/s41531-022-00411-x article EN cc-by npj Parkinson s Disease 2022-11-12

Data on non-motor symptoms (NMS) in black Africans with Parkinson's disease (PD) are sparse.To describe the profile of NMS Nigeria PD Registry (NPDR) cohort and explore relationship between motor phenotype.We conducted a cross-sectional study frequency burden NMS, based scale (NMSS) Chaudhuri method respectively our cohort. Baseline demographics, characteristics (Hoehn Yahr stage, MDS-UPDRS total score Part III score), phenotype (based Stebbin et al's algorithm), levodopa equivalent daily...

10.1002/mdc3.13346 article EN Movement Disorders Clinical Practice 2021-09-17

Abstract The relationship between APOE polymorphisms and Parkinson’s disease (PD) in black Africans has not been previously investigated. We evaluated the association polymorphic variability cognition 1100 Nigerians with PD 1097 matched healthy controls. Cognition was assessed using single item question (item 1.1) of MDS-UPDRS. genotype allele frequencies did differ controls (p > 0.05). No allelic or genotypic observed age at onset PD. In PD, ε 4/ 4 conferred a two-fold risk cognitive...

10.21203/rs.3.rs-1753416/v1 preprint EN cc-by Research Square (Research Square) 2022-07-06

The microtubule-associated protein tau ( MAPT ) gene is critical because of its putative role in the causal pathway neurodegenerative diseases including Parkinson's disease (PD). However, there a lack clarity regarding link between main H1 haplotype and risk PD. Inconsistencies reported association may be driven by genetic variability populations studied to date. Data on frequencies general population studies exploring haplotypes conferring PD black Africans are lacking.To determine explore...

10.1101/2023.03.24.23287684 preprint EN cc-by-nc-nd medRxiv (Cold Spring Harbor Laboratory) 2023-03-24
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