Bimbo Fawale
A5076162050- Acute Ischemic Stroke Management
- Stroke Rehabilitation and Recovery
- Cerebrovascular and Carotid Artery Diseases
- Epilepsy research and treatment
- Sleep and related disorders
- Obstructive Sleep Apnea Research
- Parkinson's Disease Mechanisms and Treatments
- Blood Pressure and Hypertension Studies
- Autism Spectrum Disorder Research
- Sleep and Wakefulness Research
- Pharmacological Effects and Toxicity Studies
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cancer-related gene regulation
- Cardiovascular Health and Disease Prevention
- Obesity, Physical Activity, Diet
- Biotechnology and Related Fields
- Neuroscience of respiration and sleep
- RNA regulation and disease
- Restless Legs Syndrome Research
- Venous Thromboembolism Diagnosis and Management
- Global Public Health Policies and Epidemiology
- Sleep and Work-Related Fatigue
- Nuclear Receptors and Signaling
- Organ Donation and Transplantation
- Clinical practice guidelines implementation
Obafemi Awolowo University
2016-2025
Obafemi Awolowo University Teaching Hospitals Complex
2015-2023
University College London
2021
National Hospital for Neurology and Neurosurgery
2021
Hackensack Meridian Health
2021
Hospital de Sant Pau
2021
Kwame Nkrumah University of Science and Technology
2020
University of Ghana
2020
Adekunle Ajasin University
2017
Ekiti State University
2017
BackgroundSub-Saharan Africa has the highest incidence, prevalence, and fatality from stroke globally. Yet, only little information about context-specific risk factors for prioritising interventions to reduce burden in sub-Saharan is available. We aimed identify characterise effect of top modifiable Africa.MethodsThe Stroke Investigative Research Educational Network (SIREN) study a multicentre, case-control done at 15 sites Nigeria Ghana. Cases were adults (aged ≥18 years) with confirmed by...
Background and Purpose— The relative contributions of racial geographic factors to higher risk stroke in people African ancestry have not been unraveled. We compared type vascular among indigenous Africans (IA), Americans (AA), European (EA). Methods— SIREN (Stroke Investigative Research Educational Network) is a large multinational case–control study West Africa—the ancestral home 71% AA—whereas REGARDS (Reasons for Geographic Racial Differences Stroke) cohort including AA EA the United...
<h3>Objective</h3> To characterize risk factors for spontaneous intracerebral hemorrhage (sICH) occurrence and severity among West Africans. <h3>Methods</h3> The Stroke Investigative Research Educational Network (SIREN) study is a multicenter case-control involving 15 sites in Ghana Nigeria. Patients were adults ≥18 years old with CT-confirmed sICH age-, sex-, ethnicity-matched stroke-free community controls. Standard instruments used to assess vascular, lifestyle, psychosocial factors....
Abstract Background African ancestry populations have the highest burden of stroke worldwide, yet genetic basis in these is obscure. The Stroke Investigative Research and Educational Network (SIREN) a multicenter study involving 16 sites West Africa. We conducted first-ever genome-wide association (GWAS) indigenous Africans. Methods Cases were consecutively recruited consenting adults (aged > 18 years) with neuroimaging-confirmed ischemic stroke. Stroke-free controls ascertained using...
Creutzfeldt–Jakob disease is a neurodegenerative disorder that can present with neuropsychiatric features such as dementia; it rare cause of rapidly progressive dementia. There are no previously reported cases probable or confirmed in Nigeria. A 68-year-old Nigerian Yoruba woman known hypertension presented 6-week history progressively worsening decline memory, incoherent speech, irrational behavior, visual hallucinations, acute insomnia, and inability to independently perform activities...
Background: Adequate sleep is crucial for well-being. Long hours of work observed among resident and intern doctors disrupt promote health risks sleep-induced morbidity mortality. Aim: This study aimed to examine the impact extended on quality, patterns, duration ID RD in Nigeria. Methods: analytical cross-sectional involved participants from hospitals across Nigeria&#039;s six geopolitical zones. Data were collected via a 32-item electronic questionnaire assessing socio-demographic...
Introduction: stroke is a major public health problem worldwide. Hypertension, diabetes mellitus, dyslipidaemia and smoking are some of the common modifiable risk factors in occurrence stroke. Therefore, this study was designed to assess prevalence patterns among individuals with acute
Objective Worldwide, the highest frequencies of APOL1-associated kidney variants are found in indigenous West Africans among whom small vessel disease (SVD) ischemic stroke is most common phenotype. The objective this study was to investigate association and effect sizes 23 selected SNPs 14 genes relevance, including APOL1 G1 variants, with occurrence SVD African participants Stroke Investigative Research Education Network (SIREN) Study. Materials Methods Cases were consecutively recruited...
Understanding the genetic mechanisms underlying diseases in ancestrally diverse populations is a critical step towards realization of global application precision medicine. The African and admixed enable mapping complex traits given their greater levels diversity, extensive population substructure, distinct linkage disequilibrium patterns.Here we perform comprehensive genome-wide assessment Parkinson's disease (PD) 197,918 individuals (1,488 cases; 196,430 controls) ancestry, characterizing...
Introduction Stroke is a prominent cause of death, disability, and dementia in sub-Saharan Africa (SSA). The Investigative Research Education Network works collaboratively with stroke survivors individuals serving as community controls to comprehensively characterize the genomic, sociocultural, economic behavioral risk factors for SSA. Purpose In this paper, we aim to: i) explore attitudes, beliefs, practices related Ghana Nigeria using process qualitative description; ii) propose actions...
Background and Purpose- The interplay between sex the dominant risk factors for stroke occurrence in sub-Saharan Africa has not been clearly delineated. We compared effect sizes of by among West Africans. Methods- SIREN study (Stroke Investigative Research Educational Networks) is a case-control conducted at 15 sites Ghana Nigeria. Cases were adults aged >18 years with computerized tomography/magnetic resonance imaging confirmed stroke, controls age- sex-matched stroke-free adults....
Africa was previously insufficiently represented in the emerging discipline of biobanking despite commendable early efforts. However, with Human, Heredity, and Health (H3Africa) initiative, biorepository science has been bolstered, regional biobanks are springing up, awareness about is growing on continent. The Stroke Investigative Research Educational Network (SIREN) project a transnational, multicenter, hospital community-based study involving over 3000 cases controls recruited from 16...
Chronic renal failure and HIV/AIDS are both prevalent in Nigeria. We performed a cross-sectional analysis of function newly diagnosed, treatment-naive HIV-infected patients before initiating highly active antiretroviral therapy.Treatment-inexperienced individuals were recruited. Patients with diabetes mellitus hypertension excluded. Plasma creatinine level was used to measure the estimated glomerular filtration rate ([eGFR] by Modification Diet Renal Disease equation). Predictors eGFR...
In addition to poor socio-economic indices and a high prevalence of infectious diseases, there have been various reports rising cardiovascular with associated morbidity mortality in developing countries. These factors co-exist, resulting synergy, serious complications, difficult-to-treat conditions fatal outcomes. Hence this study was conducted determine the clustering disease risk its pattern semi-urban communities south-western Nigeria.This cross sectional over seven months 11 Nigeria.The...
Clinical disease registries are useful for quality improvement in care, benchmarking standards, and facilitating research. Collaborative networks established thence can enhance national international studies by generating more robust samples credible data promote knowledge sharing capacity building. This report describes the methodology, baseline data, prospects of Nigeria Parkinson Disease Registry.This registry was November 2016. Ethics approval obtained all sites. Basic anonymized...
Abstract Hypertension is one of the most important risk factors for stroke and cardiovascular diseases (CVD) globally. Understanding hypertension among individuals with matching characteristics patients may inform primordial/primary prevention them. This study identified community‐dwelling stroke‐free population in Ghana Nigeria. Data 4267 controls subjects Stroke Investigative Research Education Network (SIREN) Nigeria were used. Participants comprehensively assessed sociodemographic,...
Interest in sleep and disorders Africa dates back thousands of years, influenced by various cultural religious beliefs. However, the practice medicine as a specialty has been inadequate compared to other regions world. The objective this study was explore current status vis-à-vis education, professional societies, facilities, identify challenges region. A literature search major electronic databases (PubMed, Google Scholar) done. This revealed that there is high prevalence significant...
To identify the qualitative and quantitative contributions of conventional risk factors for occurrence ischemic stroke its key pathophysiologic subtypes among West Africans.The SIREN (Stroke Investigative Research Educational Network) is a multicenter, case-control study involving 15 sites in Ghana Nigeria. Cases include adults aged ≥18 years with who were etiologically subtyped using A-S-C-O-D classification into atherosclerosis, small-vessel occlusion, cardiac pathology, other causes,...