A5027350258- Antibiotic Use and Resistance
- HIV/AIDS Research and Interventions
- Hepatitis B Virus Studies
- Hepatitis C virus research
- HIV, Drug Use, Sexual Risk
- Vaccine Coverage and Hesitancy
- COVID-19 Clinical Research Studies
- Antibiotic Resistance in Bacteria
- Global Maternal and Child Health
- Viral Infections and Outbreaks Research
- Pharmaceutical Practices and Patient Outcomes
- COVID-19 and healthcare impacts
- Infection Control in Healthcare
- Tuberculosis Research and Epidemiology
- Pneumocystis jirovecii pneumonia detection and treatment
- Fungal Infections and Studies
- HIV Research and Treatment
- Adolescent Sexual and Reproductive Health
- SARS-CoV-2 and COVID-19 Research
- Patient Satisfaction in Healthcare
- Liver Disease Diagnosis and Treatment
- COVID-19 epidemiological studies
- Antifungal resistance and susceptibility
- Disaster Response and Management
- Urinary Tract Infections Management
University of Sierra Leone
2018-2025
Ministry of Health and Sanitation
2020-2025
Sierra Leone Urban Research Centre
2019-2023
Ospedale di Macerata
2023
Lagos State Health Service Commission
2023
Ekiti State University
2023
University of Macerata
2023
Brunel University of London
2023
Network Group (Czechia)
2023
Case Western Reserve University
2022
BackgroundSub-Saharan Africa has the highest incidence, prevalence, and fatality from stroke globally. Yet, only little information about context-specific risk factors for prioritising interventions to reduce burden in sub-Saharan is available. We aimed identify characterise effect of top modifiable Africa.MethodsThe Stroke Investigative Research Educational Network (SIREN) study a multicentre, case-control done at 15 sites Nigeria Ghana. Cases were adults (aged ≥18 years) with confirmed by...
Introduction Very little is known about possible clinical sequelae that may persist after resolution of acute COVID-19. A recent longitudinal cohort from Italy including 143 patients followed up hospitalisation with COVID-19 reported 87% had at least one ongoing symptom 60-day follow-up. Early indications suggest need even more psychological support than typical intensive care unit patients. The assessment risk factors for longer term consequences requires a study linked to data on...
Abstract Background There is limited information on surgical site infections (SSI) and the related antibiotic resistance needed to guide their management prevention in Sierra Leone. In this study, we aimed establish incidence risk factors of SSI among adults attending a tertiary hospital, secondary health facility Freetown, Methods This prospective cohort study designed collect data from adult (18 years or older) patients who attended elective emergency surgeries at two hospitals Freetown...
As of 26 March 2021, the Africa Centres for Disease Control and Prevention had reported 4 159 055 cases COVID-19 111 357 deaths among 55 African Union member states; however, no country has published a nationally representative serosurvey as October 2021. Such data are vital understanding pandemic's progression on continent, evaluating containment measures, policy planning.We conducted cross-sectional, representative, age-stratified in Sierra Leone 2021 by randomly selecting 120 Enumeration...
The COVID-19 pandemic has adversely affected tuberculosis (TB) care delivery in high burden countries. We therefore conducted a retrospective study to assess the impact of on TB case detection and treatment outcomes at Chest Clinic Connaught Hospital Freetown, Sierra Leone. Overall, 2300 presumptive cases were tested during first three quarters 2020 (intra-COVID-19) versus 2636 2019 (baseline), representing 12.7% decline. Testing declined by 25% women, 20% children 81% community-initiated...
Inappropriate use of antibiotics during the COVID-19 pandemic has potential to increase burden antimicrobial resistance. In this study, we report on prevalence antibiotic and its associated factors among suspected confirmed patients admitted 35 health facilities in Sierra Leone from March 2020–March 2021. This was a cross-sectional study using routinely collected patient data. Of 700 patients, 47% received antibiotics. The majority (73%) belonged ’WATCH’ group antibiotics, which are highly...
Abstract Background HIV infection is a growing public health problem in Sierra Leone and the wider West Africa region. The countrywide prevalence was estimated at 1.7% (67,000 people), with less than 30% receiving life-saving ART 2016. Thus, HIV-infected patients tend to present facilities late, high mortality risk. Methods We conducted prospective study of inpatients aged ≥15 years Connaught Hospital Freetown—the main referral hospital Leone—from July through September 2017, assess...
Despite having safe and efficacious vaccines against COVID-19, vaccine hesitancy is widespread. Although a trusted source of information, has been reported among healthcare professionals, yet few studies have explored this phenomenon in sub-Saharan Africa. We conducted cross-sectional survey professionals Sierra Leone from January to March 2022. Measures included sociodemographic/health-related information COVID-19-related concerns. From the responses, we constructed (VAX) score, with higher...
As there are no country-representative data on bacterial sensitivities to guide antimicrobial stewardship (AMS) interventions, an AMS programme was established in the outpatient clinics of three tertiary hospitals Freetown, Sierra Leone.The study employed a cross-sectional design collect antibiotic prescribing from 370 pregnant women and lactating mothers, 314 children 229 regular patients Princess Christian Maternity Hospital (PCMH), Ola During Children's Connaught (CH), respectively, April...
Metabolic syndrome (MetS) is a global health concern, especially for low and middle-income countries with limited resources information. The study's objective was to assess the prevalence of MetS in Freetown, Sierra Leone, using National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III), International Diabetes Federation (IDF) Harmonize ATP III. Additionally, we aimed establish concordance between these three different criteria used.
<h3>Objective</h3> To characterize risk factors for spontaneous intracerebral hemorrhage (sICH) occurrence and severity among West Africans. <h3>Methods</h3> The Stroke Investigative Research Educational Network (SIREN) study is a multicenter case-control involving 15 sites in Ghana Nigeria. Patients were adults ≥18 years old with CT-confirmed sICH age-, sex-, ethnicity-matched stroke-free community controls. Standard instruments used to assess vascular, lifestyle, psychosocial factors....
Antimicrobial Resistance (AMR) is a growing global health challenge that threatens to undo gains in human and animal health. Prevention control of AMR requires functional antimicrobial stewardship (AMS) program, which complex often difficult implement low- middle-income countries. We aimed describe the processes establishing implementing an AMS program at Connaught Hospital Sierra Leone. The project involved setting up capacity building performing point prevalence survey (GPPS) Leone's...
Objective Inappropriate use of antibiotics is a major driver antibiotic resistance. A few studies conducted in Africa have documented that about half hospitalised patients who receive should not received them. hospital-based been Sierra Leone high usage hospitals. Therefore, we nationwide point prevalence survey on among Leone. Design We hospital-based, cross-sectional the using WHO methodology. Setting The study was 26 public and private hospitals are providing inpatient healthcare...
Abstract Background Advanced HIV disease (AHD) in young people living with (PLHIV) is an increasingly pressing public health issue sub-Saharan Africa. Despite global progress early testing and reducing HIV-related deaths, many youths experience increased rates of progression This study describes the burden, clinical manifestations, factors for among PLHIV aged 15 – 24 years seeking medical services at a major hospital Sierra Leone. Methods We performed cross-sectional analysis routinely...
Background: Malaria in pregnancy contributes to high maternal mortality, warranting the adoption of intermittent preventive treatment (IPTp) malaria Sierra Leone 2017. Since then, uptake IPTp has increased but it is unclear whether COVID-19 any impact on these services. We aimed assess among pregnant women at district, regional, and national levels. Methods: A retrospective cross-sectional study design was used monthly aggregated data from DHIS2 for all 5 regions Leone. describe trends...
Background A key milestone in the reduction of global burden HIV is reaching UNAIDS 95-95-95 target by 2025. The COVID-19 pandemic may have affected ability countries to achieve this target, but data describe impact limited. This study assessed national testing service uptake Sierra Leone during three periods from March 2019 February 2022: before, during, and after pandemic. Methods We conducted a retrospective cross-sectional using secondary program all patients tested for public private...
Background This study evaluated the resilience and outcomes of maternal health services during COVID-19 pandemic in two facilities eastern Sierra Leone. Its aims to describe use healthcare neonatal these before, during, after pandemic. Methods The involved analysis routine programme data (March 2019 February 2022) from public-funded supported by a non-governmental organization (Partners In Health Leone): Koidu Government Hospital Wellbody Clinic. Aggregated de-identified secondary Partner...
Abstract Introduction Sierra Leone is one of the worst affected by hunger and food insecurity, but data to understand impact public health emergencies on nutrition indicators limited. In this study, we sought describe service delivery nutritional among children under age five before during Ebola epidemic, inter-epidemic period, COVID-19 pandemic (2021) in Leone. Methods We conducted a descriptive study using secondary from serial cross-sectional surveys representative sampling as part...
Background The Ebola epidemic and COVID-19 pandemic disrupted essential healthcare services globally, including family planning, but the extent of disruptions in Sierra Leone is largely unknown. This study aimed to evaluates impact these crises on uptake contraceptive methods—short-acting contraceptives (SAC) long-acting reversible (LARC)—among adolescent girls women ages 10-45 years from 2013 2022. Methods We conducted a retrospective, cross-sectional using aggregated DHIS2 data aged years....
Background The COVID-19 pandemic severely impacted health systems in several countries, including Sierra Leone, which was recovering from the 2014-2016 Ebola Virus Disease epidemic. National Referral Service established 2017 followed by launching of Emergency Medical Services (NEMS) 2018 to strengthen country's referral system as part post-Ebola recovery strategy. This study examined impact on and hospital bed occupancy Leone. Methods We conducted a retrospective using individual-level daily...
Background: Sustained access to and uptake of antiretroviral therapy (ART) among people living with HIV is a critical component the response. Limited data exist evaluating extent which COVID-19 pandemic may have disrupted treatment services in Sierra Leone. This study aims describe differential patterns ART before, during, after emergency period country. Methods: We conducted retrospective cross-sectional using aggregated secondary program extracted from national health information system...