A5022954529- Heart Rate Variability and Autonomic Control
- Cardiovascular Syncope and Autonomic Disorders
- Metabolism and Genetic Disorders
- Pulmonary Hypertension Research and Treatments
- Congenital Heart Disease Studies
- Cardiac Arrhythmias and Treatments
- Porphyrin Metabolism and Disorders
- Genetic Neurodegenerative Diseases
- Biochemical and Molecular Research
- Genomic variations and chromosomal abnormalities
- Autoimmune Bullous Skin Diseases
- Cutaneous lymphoproliferative disorders research
- Neuroscience of respiration and sleep
- Skin and Cellular Biology Research
- Dermatological and Skeletal Disorders
- Diet and metabolism studies
- Liver Disease and Transplantation
- Mitochondrial Function and Pathology
- Neonatal Health and Biochemistry
- Pleural and Pulmonary Diseases
- Hormonal and reproductive studies
- Pancreatitis Pathology and Treatment
- Neurological and metabolic disorders
- Neurological disorders and treatments
- Urticaria and Related Conditions
Tel Aviv University
2011-2024
Tel Aviv Sourasky Medical Center
2015-2024
Tulane Medical Center
2020
GTx (United States)
2018
Cincinnati Children's Hospital Medical Center
2018
Guy's and St Thomas' NHS Foundation Trust
2018
New York University
2015
Dysautonomia Foundation
2015
Harvard University Press
2011
Rambam Health Care Campus
1997-2010
Orthostatic intolerance is a syndrome characterized by lightheadedness, fatigue, altered mentation, and syncope associated with postural tachycardia plasma norepinephrine concentrations that are disproportionately high in relation to sympathetic outflow. We tested the hypothesis impaired functioning of transporter contributes pathophysiologic mechanism orthostatic intolerance.
The postural tachycardia syndrome is a common disorder that characterized by chronic orthostatic symptoms and dramatic increase in heart rate on standing, but does not involve hypotension. Several lines of evidence indicate this may result from sympathetic denervation the legs.
Chronic orthostatic intolerance (COI) is a debilitating autonomic condition in young adults. Its neurohumoral and hemodynamic profiles suggest possible alterations of postural sympathetic function baroreflex control heart rate (HR).In 16 COI patients healthy volunteers, intra-arterial blood pressure (BP), ECG, central venous (CVP), muscle nerve activity (MSNA) were recorded at rest during 75 degrees tilt. Spectral analysis RR interval systolic arterial (SAP) variabilities provided indices...
Idiopathic orthostatic tachycardia (IOT) is characterized by an increase in heart rate (HR) with standing of > or = 30 bpm that associated elevated catecholamine levels and symptoms. A dynamic hypovolemia alpha1-adrenoreceptor hypersensitivity have been demonstrated IOT patients. There evidence autonomic neuropathy affecting the lower-extremity blood vessels.We studied effects placebo, agonist midodrine (5 to 10 mg), alpha2-adrenoreceptor clonidine (0.1 I.V. saline (1 L) 13 patients IOT....
Conflicting data exist on the role of nitric oxide (NO) in cerebral blood flow (CBF) autoregulation. Previous studies involving human and animal subjects seem to indicate that NO involvement is limited CO(2)-dependent mechanism (chemoregulation) not pressure-dependent autoregulation (mechanoregulation). We tested this hypothesis patients with impaired endothelial function compared healthy controls. Blood pressure, heart rate, end-tidal Pco(2), CBF velocities (CBFV), forearm flow, reactive...
To characterize the functional brain changes involved in δ-9-tetrahydrocannabinol (THC) modulation of chronic neuropathic pain.Fifteen patients with radicular pain participated a randomized, double-blind, placebo-controlled trial employing counterbalanced, within-subjects design. Pain assessments and resting state scans were performed at baseline after sublingual THC administration. We examined connectivity anterior cingulate cortex (ACC) pain-related network dynamics using graph theory...
Gonadal hormones may affect homeostatic mechanisms regulating the cardiovascular system. We investigated this relationship at five different crucial hormonal time points along menstrual cycle. Eight eumenorrheic healthy subjects underwent a battery of autonomic tests, hemodynamics, and volume-regulatory hormone measurements. Fluid-regulatory hormones, plasma renin activity, aldosterone increased luteal phase (P = 0.003 0.02, respectively), whereas rest supine-corrected hematocrit declined in...
Background— From animal studies it emerged that nitric oxide is important for the modulation of CO 2 -mediated cerebral blood flow (CBF chemoregulation) but not pressor-dependent mechanism (mechanoregulation). This hypothesis was tested in 18 healthy subjects. Methods and Results— Peak velocity (PV), diastolic (DV), mean (MV) were measured by transcranial Doppler middle artery. Chemoregulation assessed during normocapnia, hypocapnia, after inhaled mixture 95% O +5% . Mechanoregulation...
Upright posture leads to rapid pooling of blood in the lower extremities and shifts plasma fluid into surrounding tissues. This results a decrease volume (PV) hemoconcentration. There has been no integrative evaluation concomitant neurohumoral PV with upright normal subjects. We studied 10 healthy subjects after 3 days stable Na + K intake. was assessed by Evans blue dye method changes hematocrit. Norepinephrine (NE), NE spillover, epinephrine (Epi), vasopressin, renin activity, aldosterone,...
The resurgence of COVID-19 cases since June 2021, referred to as the fourth wave, has led approval and administration booster vaccines. Our study aims identify any associations between vaccine status with characteristics outcomes patients hospitalized severe disease.We retrospectively reviewed all admitted a large tertiary center July 25 October 25, 2021 (fourth wave in Israel). Univariant multivariant analyses variables associated were performed.Overall, 349 or critical disease included....
Background —Chronic orthostatic intolerance (OI) is characterized by symptoms of inadequate cerebral perfusion with standing, in the absence significant hypotension. A heart rate increase ≥30 bpm typical. Possible underlying pathophysiologies include hypovolemia, partial dysautonomia, or a primary hyperadrenergic state. We tested hypothesis that patients OI have functional abnormalities autonomic neurons regulating cardiovascular responses. Methods and Results —Thirteen chronic 10 control...
Aging, independently from the hormonal status, is a major risk factor for cardiovascular morbidity in healthy women. Therefore, we studied effect of aging on homeostatic mechanisms premenopausal and postmenopausal women with similar estrogen levels. Twelve women, confirmed by follicular-stimulating hormone (FSH) luteal (LH) levels, were compared 14 normally menstruating during early follicular phase (young-EF), to avoid as much possible effects estrogen. Systolic BP was 108 +/- 1.5 vs. 123...
The diagnosis of neuropathic postural tachycardia syndrome (POTS) requires research techniques not available clinically. We hypothesized that these patients will have impaired vagal and sympathetic cardiovascular control can be characterized with clinical autonomic tests. included 12 POTS possible subtype because normal plasma norepinephrine no increase in upright blood pressure. compared them to 10 healthy subjects. assessed hemodynamics, heart rate pressure variability, baroreflex...
Severe COVID-19 infections present with cytokine storms, hypercoagulation, and acute respiratory distress syndrome, extracellular vesicles (EVs) being involved in coagulation inflammation. This study aimed to determine whether profiles EVs reflect disease severity. Thirty-six patients symptomatic infection mild/moderate/severe (12 each group) were analyzed. Sixteen healthy individuals served as controls. Coagulation EV characteristics tested by nanoparticle tracking analysis (NTA), flow...
<title>Abstract</title> Chronic pain often involves abnormalities in central processing. Two commonly used experimental methods for modulation are conditioned (CPM) and offset analgesia (OA). However, it is uncertain how similar the underlying processes they measure are. Here, we applied CPM OA patients with fibromyalgia, a model disease of sensitization, to explore these questions further. Fifty-four female participants (27 fibromyalgia 27 healthy participants) completed Fibromyalgia Impact...
Premenstrual syndrome (PMS) presents with emotional and physical symptoms. Although the symptoms have been extensively studied, pathophysiology of fluid-retention is not currently known. We tested hypothesis that fluid regulatory mechanisms are disturbed in PMS. Nine regularly menstruating women PMS were compared 9 healthy age-matched women. Hemodynamic parameters upright plasma volume shift (extrapolated from changes hematocrit), renin activity (PRA), aldosterone sex hormones measured at...