A5021618843- Diabetes, Cardiovascular Risks, and Lipoproteins
- Liver Disease Diagnosis and Treatment
- Heart Rate Variability and Autonomic Control
- Cardiovascular Syncope and Autonomic Disorders
- Alcohol Consumption and Health Effects
- Cardiovascular Health and Disease Prevention
- Obesity, Physical Activity, Diet
- Genetic and phenotypic traits in livestock
- Adipokines, Inflammation, and Metabolic Diseases
- Chronic Kidney Disease and Diabetes
- Metabolism, Diabetes, and Cancer
- Cardiovascular Disease and Adiposity
- Blood Pressure and Hypertension Studies
- Pharmacy and Medical Practices
- Diabetes Treatment and Management
- Risk Perception and Management
- Diet, Metabolism, and Disease
- Palliative Care and End-of-Life Issues
- Renal Diseases and Glomerulopathies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Botulinum Toxin and Related Neurological Disorders
- Diabetes Management and Research
- Diet and metabolism studies
- Interdisciplinary Research and Collaboration
- Gallbladder and Bile Duct Disorders
Tokyo Women's Medical University Adachi Medical Center
2019-2024
University of Toyama
2024
Tokyo Metropolitan University
2023
Osaka Metropolitan University
2023
Osaka City University
2012-2022
Gunma University
2022
Hidaka Hospital
2022
Kochi Medical School Hospital
2005-2021
Vanderbilt University
2007-2019
Nagoya City University
2018
OBJECTIVE—Because skeletal muscle is one of the target tissues for insulin, mass might be associated with type 2 diabetes. Serum creatinine a possible surrogate marker mass. The purpose this study was to determine whether serum level RESEARCH DESIGN AND METHODS—The participants were nondiabetic Japanese men (n = 8,570) aged 40–55 years at entry. Type diabetes diagnosed if fasting plasma glucose ≥126 mg/dl or taking oral hypoglycemic medication insulin. RESULTS—During 4-year follow-up period,...
Asian Americans manifest type 2 diabetes at low BMI levels but may not undergo diagnostic testing for if the currently recommended screening cut point of ≥25 kg/m(2) is followed. We aimed to ascertain an appropriate lower among Asian-American adults without a prior diagnosis.We consolidated data from 1,663 participants, ages ≥45 years, diagnosis, population- and community-based studies, including Mediators Atherosclerosis in South Asians Living America study, North Kohala Study, Seattle...
Given the growing centrality of interdisciplinarity to scientific research, gaining a better understanding successful interdisciplinary collaborations has become imperative. Drawing on extensive case studies nine research networks in social, natural, and computational sciences, we propose construct that captures multidimensional character such collaborations, shared cognitive–emotional–interactional (SCEI) platform. We demonstrate its value as an integrative lens examine markers conditions...
Background An outbreak of cholangiocarcinoma occurred among workers in the offset color proof-printing department at a printing company Japan. The aim this study was to clarify characteristics patients with cholangiocarcinoma. Methods This retrospective conducted 13 Japanese hospitals between 1996 2013. clinicopathological findings developed 17 111 former or current were investigated. Most relatively young. Results diagnosed 25–45 years old. They exposed chemicals, including dichloromethane...
OBJECTIVE We prospectively assessed whether the combined measurements of fasting plasma glucose (FPG) and A1C were effective for predicting type 2 diabetes. RESEARCH DESIGN AND METHODS Study participants included 6,736 nondiabetic Japanese men aged 40–55 years. Type diabetes was diagnosed in those who had an FPG ≥126 mg/dl or being treated with oral antidiabetic agent insulin. The models including FPG, A1C, both compared using area under receiver operating characteristic (AUROC) curves....
Glomerular hyperfiltration and albuminuria accompanied by early-stage diabetic kidney disease predict future renal failure. Cigarette smoking has reported to be associated with elevated GFR in cross-sectional studies deterioration longitudinal studies. The degree of glomerular proteinuria smoking, which presumably is a phenomenon early damage, not been investigated satisfying manner so far.
OBJECTIVE To examine whether the patterns of insulin concentration during oral glucose tolerance test (OGTT) predict type 2 diabetes. RESEARCH DESIGN AND METHODS We followed 400 nondiabetic Japanese Americans for 10–11 years. Insulin concentrations at 30, 60, and 120 min a 2-h 75-g OGTT baseline were used to derive following possible insulin: pattern 1 (30-min peak, higher level 60 than min), lower or equal vs. 3 (60-min peak); 4 (120-min 30 5 min). sensitivity was estimated by homeostasis...
BackgroundIndication of tonsillectomy in IgA nephropathy is controversial. The purpose this study was to examine the efficacy on remission and progression nephropathy.
Objective To examine cross‐sectionally whether intraabdominal fat area (IAFA), i.e., visceral fat, and liver assessed by computed tomography (CT) are independently associated with hyperuricemia. Methods Subjects were 801 Japanese men not taking antidiabetic, antihypertensive, or urate‐lowering medications, without any history of renal disease, cardiovascular cancer, serum creatinine <1.5 mg/dl. Abdominal, thoracic, thigh areas measured CT. Total (TFA) was the sum these areas. subcutaneous...
The diagnosis of neuropathic postural tachycardia syndrome (POTS) requires research techniques not available clinically. We hypothesized that these patients will have impaired vagal and sympathetic cardiovascular control can be characterized with clinical autonomic tests. included 12 POTS possible subtype because normal plasma norepinephrine no increase in upright blood pressure. compared them to 10 healthy subjects. assessed hemodynamics, heart rate pressure variability, baroreflex...
It has been reported that moderate alcohol consumption decreased the risk of type 2 diabetes but elevated liver enzymes increased it. The comparative importance and as predictors remains unconfirmed.The participants included 8,576 Japanese men, aged 40-55 years, without at entry. Type was diagnosed if a fasting plasma glucose level >or=126 mg/dl or were taking oral hypoglycemic medications insulin.During 4-year follow-up period, we confirmed 878 cases. In multivariate models, daily...
The acetylcholinesterase inhibitor donepezil hydrochloride improves cognitive function in patients with Alzheimer's disease and vascular dementia. Given acetylcholine's important actions on the heart, we undertook a retrospective cohort investigation to assess whether usage affects cardiovascular mortality. In treated donepezil, hazard ratios for total mortality were 0.68 (P = 0.045, 95% confidence interval 0.46–0.99) 0.54 0.042, 0.30–0.98), respectively. apparent survival benefit...
Previous epidemiological studies have shown that vigorous physical activity reduces the development of type 2 diabetes (1–3). A recommendation from Centers for Disease Control and Prevention reported individuals should engage in ≥30 min moderate-intensity activity, such as brisk walking, on most days week health promotion disease prevention (4); however, it is unclear whether mild (i.e., walking to walk) risk diabetes. In present study, we examined relationship between work during a 4-year...
<h3>Objectives</h3> This study aimed to evaluate the relationship between cumulative exposure 1,2-dichloropropane (1,2-DCP) and incidence risk of cholangiocarcinoma among workers in offset proof-printing section a small printing company Osaka, Japan. <h3>Methods</h3> We identified 95 (78 men 17 women) who had been exposed 1,2-DCP 1987 2006, calculated standardised ratio (SIR) from 2012. estimated SIRs four categories. also rate ratios (RRs) adjusted by sex, age, calendar year dichloromethane...
Because of their favorable prognostic effects, angiotensin converting enzyme inhibitors (ACEI), II receptor blockers (ARB) and beta have become background therapy in dilated cardiomyopathy (DCM). However, there are few reports concerning the long-term prognosis Japanese patients with DCM relation to these treatments.One hundred fifty were divided into 2 groups: group A (n=46) (diagnosis: 1982-1989) B (n=104) 1990-2002). During follow-up period 6.9+/-4.8 years, 62 died 1 patient had a heart...
Aims/Introduction: Reduced insulin sensitivity and secretion are important in the pathogenesis of type 2 diabetes. Their relationships to prediabetes, impaired glucose tolerance (IGT) fasting (IFG) have been previously studied with oral test (OGTT). We investigated whether or not baseline measures obtained from blood specimens were related development prediabetes how these compared those based on OGTT. In 152 Japanese subjects normal tolerance, we measured plasma after an overnight fast...
The association between alcohol consumption and the risk of chronic kidney disease (CKD) has been reported. What is not known whether drinking pattern combined with weekly frequency quantity per day associated CKD.We enrolled 9,112 Japanese nondiabetic men aged 40 to 55 years absence proteinuria, an estimated glomerular filtration rate (eGFR) 60 ml/min/1.73 m(2) or higher, on antihypertensive medications at baseline. CKD was defined if eGFR <60 m(2). classification nondrinkers, 1-3...
<h3>Abstract</h3> Central release of the neuropeptide oxytocin (OXT) modulates neural substrates involved in socio-affective behavior. This property has prompted research into use intranasal OXT administration as an adjunctive therapy for brain conditions characterized by social impairment, such autism spectrum disorders (ASD). However, circuitry and brain-wide functional networks recruited remain elusive. Moreover, little is known neuroadaptive cascade triggered long-term this peptide at...
Butyrylcholinesterase is synthesized in the liver. The serum butyrylcholinesterase level has been cross-sectionally reported to be higher patients with diabetes, hyperlipidaemia, obesity and fatty liver than those without them. It not known whether associated risk of future type 2 diabetes.A prospective cohort study.A total 8470 Japanese men aged 40-55 years diabetes at baseline.Type was diagnosed if a fasting plasma glucose (FPG) ≥7·0 mmol/l, HbA1 c ≥6·5% or participants were taking oral...
Abstract Restricted maximum likelihood analyses fitting an animal model were conducted to estimate genetic parameters with a pooled-data set of performance tests (growth traits and food intake) on 661 bulls progeny carcass traits) 535 steers. Traits studied included concentrate intake (CONC), roughage (ROU), TDN conversion (TCNV), (TINT) bulls; rib eye area (REA), marbling score (MARB), dressing proportion (DRES) subcutaneous fat depth (SCF) Body weight at start (BWS), body finish (BWF)...
Abstract Aim: The prevalence of underweight women, who have an increased risk for small‐for‐gestational‐age (SGA) birth, is increasing in Japan. We examined the associations pre‐pregnancy body mass index and gestational weight gain (GWG) with SGA birth among Japanese women. Material Methods: conducted a prospective cohort study 1391 women delivered full‐term singleton babies. was defined as below 10th percentile birthweight at each age, baby sex, parity. calculated 5th same way another...