A5017091939- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Syphilis Diagnosis and Treatment
- Alzheimer's disease research and treatments
- Botulinum Toxin and Related Neurological Disorders
- Olfactory and Sensory Function Studies
- Parkinson's Disease and Spinal Disorders
- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Biochemical Analysis and Sensing Techniques
- Nerve injury and regeneration
- Cerebral Palsy and Movement Disorders
- Myasthenia Gravis and Thymoma
- Cholinesterase and Neurodegenerative Diseases
- Reproductive tract infections research
- Neurological diseases and metabolism
- Functional Brain Connectivity Studies
- Neurological and metabolic disorders
- Balance, Gait, and Falls Prevention
- Neurogenesis and neuroplasticity mechanisms
- Peripheral Neuropathies and Disorders
- Advanced Chemical Sensor Technologies
- Autism Spectrum Disorder Research
- Neuropeptides and Animal Physiology
New York State Department of Agriculture and Markets
2024
Reading Hospital
2023
Maastricht University
2013-2020
University Hospital of Zurich
2013-2014
Amsterdam UMC Location Vrije Universiteit Amsterdam
2004-2012
Amsterdam Neuroscience
1994-2009
Vrije Universiteit Amsterdam
1998-2008
Amsterdam University of Applied Sciences
2007
Dutch Institute for Fundamental Energy Research
2005
Graduate School Neurosciences Amsterdam Rotterdam
1997-2005
Magnetic resonance imaging (MRI) has shown a great reduction in medial temporal lobe and hippocampal volume of patients with Alzheimer9s disease as compared to controls. Quantitative volumetric measurements are not yet available for routine clinical use. We investigated whether visual assessment atrophy (MTA) on plain MRI films could distinguish (n = 21) from age matched controls 21). The degree MTA was ascertained ranking procedure validated by linear the including formation surrounding...
Cholinergic deficits are prominent in patients who have dementia associated with Parkinson's disease. We investigated the effects of dual cholinesterase inhibitor rivastigmine such patients.
Abstract Olfactory dysfunction is an early and common symptom in Parkinson's disease (PD). In effort to determine whether otherwise unexplained (idiopathic) olfactory associated with increased risk of developing PD, we designed a prospective study cohort 361 asymptomatic relatives (parents, siblings, or children) PD patients. A combination detection, identification, discrimination tasks was used select groups hyposmic (n = 40) normosmic 38) individuals for 2‐year clinical follow‐up...
OBJECTIVES: The main neuropathological feature in Parkinson9s disease is a severe degeneration of the dopaminergic neurons substantia nigra resulting loss dopamine (DA) transporters striatum. [123I]beta-CIT single photon emission computed tomography (SPECT) studies have demonstrated this striatal DA transporter content vivo. However, with radioligand also showed that an adequate imaging could only be performed on day after injection radioligand, which not convenient for outpatient...
Article abstract—We investigated the histopathologic correlates of white matter changes in Alzheimer9s disease (AD) patients (n = 6) and controls 9) using postmortem MRT. White were rated on a 0 to 3 scale 51 regions. Histopathologically, we subjectively loss myelinated axons deep periventricular matter, denudation ventricular ependyma, gliosis, width perivascular spaces, leptomeningeal con-gophilic angiopathy; measured structural walls blood vessels micrometers. The AD brains displayed...
In a prospective magnetic resonance imaging (MRI) study we evaluated the prevalence and severity of white matter changes in 29 patients with Alzheimer's Disease (AD) 24 age-matched healthy elderly, all without cerebrovascular risk factors. The AD were divided into two groups according to age at onset symptoms, one presenile (n = 13) senile 16), who matched for dementia severity. Signal hyperintensities rated using semiquantitative scoring method, separately periventricular region (PVH) lobar...
Abstract By the time a clinical diagnosis of Parkinson's disease (PD) is made, significant loss dopaminergic neurons has already occurred. Identifying patients in period between presumed onset cell and appearance parkinsonism may be major importance development effective neuroprotective treatment strategies. In an effort to develop feasible strategy detect preclinical PD, combination olfactory processing tasks, including odor detection, identification, discrimination was used select groups...
We report six cases of chronic manganese intoxication in workers at a ferromanganese factory Taiwan. Diagnosis was confirmed by assessing increased concentrations the blood, scalp, and pubic hair. In addition, levels environmental air were established. The patients showed bradykinetic-rigid syndrome indistinguishable from Parkinson's disease that responded to treatment with levodopa.
Olfactory dysfunction is a common finding in patients with Parkinson's disease (PD). As most studies reported on odor identification more advanced and treated PD, we administered an detection, discrimination, test to heterogeneous, partly de novo, group of patients. Forty-one non-demented PD patients, 24 whom had untreated early 18 healthy controls, were examined. Odor discrimination data corrected for detection scores. scored significantly lower all olfactory tests. Interestingly, the...
The amyloid beta-protein is deposited in senile plaques and the cerebrovasculature Alzheimer disease (AD). Since it derived from proteolytic processing of its parent protein, precursor (APP), we investigated whether levels secreted forms APP are altered cerebrospinal fluid (CSF) AD patients. Quantitative immunoblotting studies with anti-APP monoclonal antibody P2-1 revealed that probable patients had markedly lower CSF than did demented non-Alzheimer-type healthy control subjects. Using an...
Dopamine agonists are used as initial treatment in patients with Parkinson's disease (PD) to reduce incidence and severity of motor complications. This paradigm is based on long-term studies, allowing "rescue" therapy levodopa. The present strict monotherapy study (PELMOPET, the acronym for pergolide-versus-L-dopa-monotherapy-and-positron-emission-tomography trial) evaluated efficacy safety pergolide versus levodopa without medication. multicenter, double-blind, randomized, 3-year trial...
Abstract We employed 6‐fluorodopa to study the integrity of nigrostriatal dopaminergic projection by positron emission tomography in 4 subjects with clinical features mild parkinsonism caused exposure manganese. The scans were normal. This finding suggests that early manganism sufficient cause parkinsonian deficits, damage may occur pathways postsynaptic system, probably involving striatal or pallidal neurons. Fluorodeoxyglucose showed decreased cortical glucose metabolism, significance...
A polymerase chain reaction with nested primer pairs based on the DNA sequence of 39-kDa bmp gene Treponema pallidum subsp. is described. The method allowed detection purified T. equivalent to amount in a single bacterium and was specific for subspecies. After concentration DNA, using diatomaceous earth, it possible detect about 100 treponemes 1 ml cerebrospinal fluid. Cerebrospinal fluid samples from total 29 symptomatic asymptomatic patients neurosyphilis were tested presence treponemal...