A5045900201- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Transcranial Magnetic Stimulation Studies
- Functional Brain Connectivity Studies
- Neuroscience and Neural Engineering
- Psychosomatic Disorders and Their Treatments
- EEG and Brain-Computer Interfaces
- Botulinum Toxin and Related Neurological Disorders
- Bipolar Disorder and Treatment
- Schizophrenia research and treatment
- Advanced MRI Techniques and Applications
- Glioma Diagnosis and Treatment
- Neural and Behavioral Psychology Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Cerebrospinal fluid and hydrocephalus
- Image Processing Techniques and Applications
- Muscle activation and electromyography studies
- CNS Lymphoma Diagnosis and Treatment
- Mental Health Research Topics
- Face Recognition and Perception
- Mental Health and Psychiatry
- Spinal Dysraphism and Malformations
University Medical Center Freiburg
2015-2025
University of Freiburg
2016-2025
Universitätsklinik für Stereotaktische Neurochirurgie
2024
John Wiley & Sons (United States)
2023
University of Amsterdam
2023
University Hospital Bonn
2019
Charité - Universitätsmedizin Berlin
2009-2017
University of Bonn
2011-2016
University Medical Center
2016
Short- and long-term antidepressant effects of deep brain stimulation (DBS) in treatment-resistant depression (TRD) have been demonstrated for several targets open-label studies. For two targets, pivotal randomized trials conducted; both failed a futility analysis. We assessed efficacy safety DBS the supero-lateral branch medial forebrain bundle (slMFB) small Phase I clinical study with randomized-controlled onset order to obtain data planning large RCT. Sixteen patients suffering from TRD...
Increased responsiveness to appetitive and reduced aversive anticipatory cues may be associated with dysfunction of the brain reward system in mania. Here we studied neural correlates gain loss expectation mania using functional magnetic resonance imaging (fMRI).Fifteen manic patients 26 matched healthy control individuals performed a monetary incentive delay task, during which subjects anticipated win or lose varying amount money. Varying both magnitude valence (win, loss) allowed us...
Abstract Introduction Deep brain stimulation alleviates tremor of various origins. The dentato-rubro-thalamic tract (DRT) has been suspected as a common tremor-reducing structure. Statistical evidence not obtained. We here report the results an uncontrolled case series patients with refractory who underwent deep under tractographic assistance. Methods A total 36 were enrolled (essential (17), Parkinson’s (8), multiple sclerosis (7), dystonic head (3), tardive dystonia (1)) and received 62...
Deep brain stimulation (DBS) of the superolateral branch medial forebrain bundle (slMFB) emerges as a - yet experimental treatment for major depressive disorder (MDD) and other refractory psychiatric diseases. First experiences have been reported from two open label pilot trials in depression long-term effectiveness MDD (50 months) has reported. To give detailed description surgical technique DBS MDD. Surgical experience bilateral implantation procedures n = 24 patients with is The procedure...
Major depression (MD) and obsessive-compulsive disorder (OCD) are psychiatric diseases with a huge impact on individual well-being. Despite optimal treatment regiments subgroup of patients remains resistant stereotactic surgery (stereotactic lesion surgery, SLS or Deep Brain Stimulation, DBS) might be an option. Recent research has described four networks related to MD OCD (affect, reward, cognitive control, default network) but only cortical the adjacent sub-cortical level. enormous...
The present study in hypomanic and manic patients explored how amygdala responses to affective stimuli depend on the valence of presented.We compared 10 with matched healthy control subjects. We measured blood oxygen level-dependent (BOLD) while subjects passively viewed photographs taken from International Affective Picture System. After fMRI session, saw pictures again subjectively rated emotional intensity each picture.Compared individuals, or showed higher ratings positive associated...
Directional deep brain stimulation (dDBS) relies on electrodes steering the field in a specific direction. Post implantation, however, intended and real orientation of lead frequently deviates e.g. due to torque electrode. The is assessed by postoperative imaging such as C-arm cone-beam CT (CBCT) using 3D rotational fluoroscopy multi-slice (MSCT). objective determine effect different X-ray systems CBCT MSCT, scan acquisition parameters effective radiation doses. We retrospectively...
Abstract Cognitive impairment is a major contributor to the burden in Parkinson’s disease and dementia with Lewy bodies, both of which make up body spectrum, affecting 80% patients over course disease. Macroatrophy microstructural neurodegenerative alterations are typically assessed separately MRI, although neuropathologically they represent same mechanism - loss functional tissue. To gain deeper insight into differential impact neurodegeneration basal forebrain hippocampus on cognition, we...
Abstract Objective - This work introduces Dareplane, a modular and broad technology-
agnostic open source software platform for brain-computer interface research with
an application focus on adaptive deep brain stimulation (aDBS). One difficulty for
investigating control approaches aDBS resides with the complex setups required
for experiments, challenge Dareplane tries to address.
Approach The key features of are presented composition
of...
Nigrostriatal microstructural integrity has been suggested as a biomarker for levodopa response in Parkinson's disease (PD), which is strong predictor motor to deep brain stimulation (DBS) of the subthalamic nucleus (STN). This study aimed explore impact substantia nigra (SN), STN, and putamen on STN-DBS using diffusion microstructure imaging.
Essential tremor is a movement disorder that can result in profound disability affecting the quality of life. Medically refractory essential be successfully reduced by deep brain stimulation (DBS) traditionally targeting thalamic ventral intermediate nucleus (Vim). Although this structure identified with magnetic resonance (MR) imaging nowadays, Vim-DBS electrodes are still implanted awake patient intraoperative testing to achieve satisfactory control. This attributed fact more effective...
The identification of oscillatory neural markers Parkinson's disease (PD) can contribute not only to the understanding functional mechanisms disorder, but may also serve in adaptive deep brain stimulation (DBS) systems. These systems seek online adaptation parameters closed-loop as a function markers, aiming at improving treatment's efficacy and reducing side effects. Typically, PD is based on group-level studies. Due heterogeneity symptoms across patients, however, such like beta band power...
Uncertainties concerning anatomy and function of cortico-subcortical projections have arisen during the recent years. A clear distinction between cortico-subthalamic (hyperdirect) cortico-tegmental (superolateral medial forebrain bundle, slMFB) so far is elusive. Deep Brain Stimulation (DBS) slMFB (for major depression, MD obsessive compulsive disorders, OCD) has on one hand been interpreted as actually involving limbic (prefrontal) hyperdirect pathways. On other slMFB's stimulation region...
The extent to which the degeneration of substantia nigra (SN) and putamen each contribute motor impairment in Parkinson's disease (PD) is unclear, as they are usually investigated using different imaging modalities. To examine pathophysiological significance SN both levodopa response PD diffusion microstructure (DMI). In this monocentric retrospective cross-sectional study, DMI parameters from 108 patients with 35 healthy controls (HC) were analyzed a voxel- region-based approach. Linear...
More than a decade ago, deep brain stimulation (DBS) of the superolateral medial forebrain bundle (slMFB), as part greater MFB system, had been proposed putative yet experimental treatment strategy for therapy refractory depression (TRD) and later obsessive–compulsive disorders (OCD). Antidepressant anti-OCD efficacy have shown in open case series smaller trials were independently replicated. The is anato-physiologically confluent with SEEKING system promoting euphoric drive, reward...
BackgroundUnderstanding prefrontal cortex projections to diencephalic-mesencephalic junction (DMJ), especially subthalamic nucleus (STN) and ventral mesencephalic tegmentum (VMT) helps our comprehension of Deep Brain Stimulation (DBS) in major depression (MD) obsessive-compulsive disorder (OCD). Fiber routes are complex tract tracing studies non-human primate species (NHP) have yielded conflicting results. The superolateral medial forebrain bundle (slMFB) is a promising target for DBS MD...
Thalamic deep brain stimulation (DBS) is an efficacious treatment for drug-resistant essential tremor (ET) and the dentato-rubro-thalamic tract (DRT) constitutes important target structure. However, up to 40% of patients habituate lose efficacy over time, frequently accompanied by a stimulation-induced cerebellar syndrome. The phenomenon termed delayed therapy escape (DTE) insufficiently understood. Our previous work showed that DTE clinically pronounced on non-dominant side suggested...