A5071682220- Cerebrovascular and genetic disorders
- Medical Image Segmentation Techniques
- Dementia and Cognitive Impairment Research
- Brain Tumor Detection and Classification
- Alzheimer's disease research and treatments
- Cerebrovascular and Carotid Artery Diseases
- Neurological Disease Mechanisms and Treatments
- Advanced MRI Techniques and Applications
- Moyamoya disease diagnosis and treatment
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Multiple Sclerosis Research Studies
- Advanced Neuroimaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Acute Ischemic Stroke Management
- Intracranial Aneurysms: Treatment and Complications
- Intracerebral and Subarachnoid Hemorrhage Research
- Cardiac Imaging and Diagnostics
- Fungal Plant Pathogen Control
- Rheumatoid Arthritis Research and Therapies
- Ultrasound and Hyperthermia Applications
- Bioinformatics and Genomic Networks
- Autoimmune and Inflammatory Disorders Research
- Digital Imaging for Blood Diseases
- Spectroscopy and Chemometric Analyses
Bristol-Myers Squibb (United States)
2020-2024
University of Copenhagen
2023
NIHR Leeds Musculoskeletal Biomedical Research Unit
2023
University of Leeds
2023
Glostrup Hospital
2023
Rigshospitalet
2023
Chapel Allerton Hospital
2023
Bristol-Myers Squibb (Germany)
2020-2022
Center for Translational Molecular Medicine
2022
Centre National de la Recherche Scientifique
1998-2018
To assess the safety, tolerability, and pharmacokinetic pharmacodynamic effects of -secretase inhibitor avagacestat in patients with mild to moderate Alzheimer disease (AD).Randomized, double-blind, placebo-controlled,24-week phase 2 study.Global, multicenter trial.A total 209 outpatients AD were randomized into double-blind treatment phase. The median age was 75 years,58.9% APOE ε4 carriers, baseline measures severity similar among groups.Avagacestat, 25, 50, 100, or 125 mg daily,or placebo...
The Alzheimer's Disease Neuroimaging Initiative (ADNI) three-dimensional T1-weighted magnetic resonance imaging (MRI) acquisitions provide a rich data set for developing and testing analysis techniques extracting structural endpoints. To promote greater rigor in meaningful comparison of different algorithms, the ADNI MRI Core has created standardized sets comprising scans that met minimum quality control requirements. We encourage researchers to test report their against these data. Standard...
Early identification of Alzheimer disease (AD) is important for clinical management and affords the opportunity to assess potential disease-modifying agents in trials. To our knowledge, this first report a randomized trial prospectively enrich study population with prodromal AD (PDAD) defined by cerebrospinal fluid (CSF) biomarker criteria mild cognitive impairment (MCI) symptoms.To safety γ-secretase inhibitor avagacestat PDAD determine whether CSF biomarkers can identify patient prior...
Cerebral small vessel disease is the most common cause of vascular cognitive impairment. It typically manifests with lacunar infarcts and ischaemic white matter lesions. However, little known about how these lesions relate to symptoms. Previous studies have found a poor correlation between burden symptoms, thus leaving much variance in performance unexplained. The objective current study was investigate relationship location subcortical symptoms disease. We applied voxel-based lesion-symptom...
Objective: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a hereditary caused by mutations of the Notch3 gene. The disease characterized T2-hyperintense lesions (subcortical white matter lesions), T1-hypointense (lacunar T2*-weighted gradient-echo (GE) (cerebral microhemorrhages [CMs]) visualized on clinical MRI sequences considered as model “pure” ischemic vascular dementia. Although numerous studies have investigated impact in...
Cerebral atrophy has been recently recognized as a key marker of disease progression in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). The contribution lesions this process remains undetermined. aim study was to investigate the relationships between volume different types MRI CADASIL.Demographic, clinical, laboratory data from 147 patients CADASIL recruited prospective cohort were analyzed. Validated methods used determine ratio brain...
Predictors of clinical worsening in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy remain unknown. This study aims to identify demographic, clinical, magnetic resonance imaging predictors incident strokes, dementia, deterioration, death patients this genetically proven disease.Two hundred ninety subjects (mean age, 50.6±11.4 years) were assessed at baseline followed up for 36 months. Incident events recorded, scores included the Mini Mental State...
To replace digital subtraction angiography (DSA) in carotid stenosis evaluation, noninvasive imaging techniques have to reach a high concordance rate. Our purpose is compare the rates of contrast-enhanced MR (CEMRA) and CT (CTA) with Doppler ultrasound (DUS) clinical routine practice.We evaluated prospectively DUS, CEMRA, CTA 150 patients suspected stenosis. The overall 3 were calculated for symptomatic > or =50% =70%, asymptomatic =60%, occlusion. For arteries treated by surgery (n=97),...
Background and Purpose— White matter hyperintensities (WMH) on MRI are a quantitative marker for sporadic cerebral small vessel disease highly heritable. To date, large-scale genetic studies have identified only single locus influencing WMH burden. This might in part relate to biological heterogeneity of WMH. The current study searched modifiers volume autosomal-dominant arteriopathy with subcortical infarcts leukoencephalopathy (CADASIL), monogenic disease. Methods— We performed genome-wide...
The authors sought to determine in a retrospective analysis whether carotid plaque soft TD on CT is associated with recent ischemic neurologic events. Among 141 patients (99 asymptomatic), 106 plaques more than 50% stenosis were selected for density measurements. They found an odds ratio events 10-point decrease of 1.54 (<i>p</i> = 0.002), showing association between and
In the concept of ischemic penumbra, volume salvaged penumbra is considered as FLAIR normalization on follow-up MRI compared with early diffusion and perfusion abnormalities. Using magnetization transfer imaging, very sensitive to macromolecular disruption, we investigated whether was a good marker for tissue full recovery.We prospectively included 30 patients acute middle cerebral artery stroke. Diffusion-weighted imaging (DWI) perfusion-weighted were performed within 12 hours after onset...
Three-dimensional MRI segmentation may be useful to better understand the physiopathology of lacunar infarctions. Using this technique, distribution infarctions volumes has been recently reported in patients with cerebral autosomal-dominant arteriopathy subcortical infarcts and leukoencephalopathy (CADASIL). Whether volume each lacune (individual [ILV]) is associated patients' other lesions or vascular risk factors never investigated. The purpose study was impact age, factors, markers on ILV...
Abstract Objectives To investigate if the OMERACT PsA MRI Scoring System (PsAMRIS), including a novel total inflammation score, shows sensitivity to change with an agent (abatacept) known impact clinical outcomes in PsA. Methods We performed post hoc analysis of randomized phase IIb study abatacept patients and inadequate DMARD response. Participants received one three dosing regimens [ABA3, ABA10 or ABA30/10 mg/kg (30 switched 10 after two doses)] placebo until day 169, then through 365....
To determine the incidence and predictors of relapse-associated worsening (RAW) progression independent relapse activity (PIRA) in participants treated with ozanimod.
Hippocampal volume (HCV) is a key biomarker for both improving subject selection and monitoring treatment efficacy in Alzheimer's Disease (AD) studies. The main goal of the Protocol (http://www.hippocampal-protocol.net/) was to harmonize multiple hippocampal protocols define standard protocol. Additionally, expert hippocampus segmentations 135 ADNI cases will be made available (100 as January 2014).The purpose this work evaluate accuracy BioClinica Multi-Atlas Segmentation (BMAS) algorithm...