A5072183192- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Syphilis Diagnosis and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- HIV-related health complications and treatments
- Antibiotic Resistance in Bacteria
- Reproductive tract infections research
- Pneumonia and Respiratory Infections
- Hepatitis Viruses Studies and Epidemiology
- Antibiotics Pharmacokinetics and Efficacy
- HIV, Drug Use, Sexual Risk
- Sex work and related issues
- Amoebic Infections and Treatments
- Escherichia coli research studies
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Antibiotic Use and Resistance
- Viral gastroenteritis research and epidemiology
- COVID-19 Clinical Research Studies
- Influenza Virus Research Studies
- Bacterial Infections and Vaccines
- Vibrio bacteria research studies
National Yang Ming Chiao Tung University
2016-2025
Far Eastern Memorial Hospital
2016-2025
National Taiwan University Hospital
2022
National Taipei University of Technology
2022
National Taipei University
2018-2020
Memorial Hospital of South Bend
2011-2015
Oriental Institute of Technology
2014-2015
Ministry of Health and Welfare
2015
National Taiwan University
2008-2010
Objectives: Since few therapeutic options exist for extensively drug resistant Acinetobacter baumannii, an emerging threat in ICUs worldwide, and comparative prospective studies of colistin-based combination therapies are lacking, our objective was to compare the outcomes patients with drug-resistant A. baumannii bacteremia, treated colistin-carbapenem colistin-tigecycline combinations. Design: Prospective, observational, multicenter study. Setting, Patients, Interventions: Adults bacteremia...
The incidence of and risk factors for Jarisch-Herxheimer (JH) reaction were investigated prospectively among 240 human immunodeficiency virus (HIV)-infected 115 HIV-uninfected patients with syphilis who received penicillin treatment. overall rate JH was 31.5% (34.6% in HIV-infected 25.2% patients). In multivariate analysis, included high rapid plasma reagin (RPR) titers (per log(2) RPR increase, ratio [RR], 1.19; 95% confidence interval [CI], 1.04-1.37), early (RR, 8.59; CI, 4.75-15.56),...
Several studies have demonstrated that significant weight gain occurs in some people living with HIV (PWH) after initiating integrase strand transfer inhibitors (INSTIs). Most on change been clinical trials primarily focused Africa, Europe, and North America, limited representation from real-world Asia. This retrospective observational study, conducted at nine designated HIV-care hospitals March 2019 to January 2024, aimed address this gap. Of the 533 patients screened, 314 met criteria for...
Abstract Background It is generally believed that HIV-1 capsid inhibitor–naïve populations are susceptible to inhibitors. Moreover, conventional resistance genotyping does not include the CA region, leading limited surveillance data. Methods We conducted a retrospective study investigate presence of mutations at positions associated with inhibitor before introduction first inhibitor, lenacapavir, in Taiwan. Capsid L56, N57, M66, Q67, K70, N74, A105, and T107 were analyzed using local...
Background: BICtegravir Single Tablet Regimen (BICSTaR) is an observational cohort study evaluating the effectiveness and safety of bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) in treatment-naïve (TN) treatment-experienced (TE) people with HIV. Objective: To present final pooled 24-month outcomes for full cohort. Methods: Prospective data were from TN TE adults HIV initiating B/F/TAF routine clinical practice across 14 countries (data collection: 25/06/2018–29/12/2023). Outcomes...
ABSTRACT Studies of macrolide resistance mutations and molecular typing using the newly proposed enhanced system for Treponema pallidum isolates obtained from HIV-infected patients in Asia-Pacific region are scarce. Between September 2009 December 2011, we conducted a survey to detect T. PCR assay clinical specimens with syphilis at six major designated hospitals HIV care Taiwan. The strains were genotyped by following methodology, which analyzed number 60-bp repeats acidic repeat protein (...
The incidence of hepatotoxicity related to trimethoprim/sulfamethoxazole (TMP/SMX) administered at a therapeutic dose may vary among study populations different ethnicities and hepatotoxic metabolites TMP/SMX be decreased by drug-drug interaction with fluconazole. We aimed investigate the role concomitant use fluconazole in HIV-infected patients receiving for Pneumocystis jirovecii pneumonia. reviewed medical records collect clinical characteristics laboratory data who received treatment P....
The international and national HIV treatment guidelines in 2016 have focused on scaling up access to combination antiretroviral therapy (cART). We aimed assess the trends outcomes of late cART initiation Taiwan.Between June 2012 May 2016, we retrospectively included antiretroviral-naive HIV-positive adults who initiated cART. Late was defined as when patients with a CD4 count <200 cells/mm3 or having experienced AIDS-defining illnesses. were assessed 6 months after starting cART.We 3655...
Spinal epidural abscess (SEA) is a rare but severe infection with potentially devastating consequences. Epidural abscesses caused by Salmonella serogroup C2 are even rarer and tend to be more invasive multidrug resistance. Early diagnosis, effective use of antibiotics surgical intervention the mainstay strategies for managing SEA, especially virulent multidrug-resistant infections. This case report presents an elderly fragile woman spondylodiscitis extensive abscess, which were successfully...
Human immunodeficiency virus type 1 (HIV-1) circulating recombinant form (CRF) 07_BC has caused serious HIV-1 epidemics among injecting drug users (IDUs) in East Asia. Little is known about the characteristics of and its impact on disease progression infected individuals. In this study, we compared immunological between 423 IDUs with CRF07_BC 194 men who have sex (MSM) primary subtype B infection, a representative full-length molecular clone, pCRF07_BC, was constructed to characterize virus....
Introduction The Jarisch‐Herxheimer reaction, a febrile inflammatory reaction that often occurs after the first dose of chemotherapy in spirochetal diseases, may result deleterious effects to patients with neurosyphilis and pregnant women. A single 2‐g oral azithromycin is an alternative treatment benzathine penicillin G for early syphilis areas low macrolide resistance. With its potential anti‐inflammatory activity, impact on incidence HIV‐positive has rarely been investigated. Methods In...
Acinetobacter baumannii causes healthcare-associated infections worldwide. Capsular polysaccharide (CPS) is shown an important virulence factor of A. both in vitro and vivo. Capsule locus 2 (KL2) for CPS the most common KL type associated with carbapenem resistance. It unclear whether KL2 related to clinical outcome invasive infection. Here we had followed patients bacteraemia prospectively between 2009 2014. One-third unduplicated blood isolates were randomly selected each year...
Our three-stage pooled plasma HCV RNA testing successfully identified viremia in high-risk PLWH with a cost reduction of 84.5%. Simulation analysis offered detailed information regarding the selection pool and mini-pool sizes settings different epidemiology performance to optimize reduction.
A recent study reported that trimethoprim/sulfamethoxazole caused acute psychosis in four renal transplant patients with Pneumocystis jirovecii pneumonia. We aimed to investigate the incidence of and factors associated trimethoprim/sulfamethoxazole-related HIV-infected P. pneumonia.We reviewed medical records who presented pneumonia received at six major hospitals Taiwan from July 2009 May 2011. Acute was defined as occurrence hallucinations or delusions following initiation during...
Objectives Two nucleos(t)ide reverse-transcriptase inhibitors (NRTIs) plus 1 non-NRTI (nNRTI) remain the preferred or alternative combination antiretroviral therapy (cART) for antiretroviral-naive HIV-positive patients in Taiwan. The three most commonly used nNRTIs are nevirapine (NVP), efavirenz (EFV) and rilpivirine (RPV). This study aimed to determine incidences of hepatotoxicity skin rashes within 4 weeks initiation cART containing nNRTI 2 NRTIs. Methods Between June, 2012 November,...
Objectives: Treatment with trimethoprim-sulfamethoxazole for Pneumocystis pneumonia (PCP) is often associated adverse effects. Echinocandins, by inhibiting the cyst form of jirovecii, may be an alternative therapy PCP. However, clinical experience echinocandins in treatment PCP remains limited among HIV-infected patients. Methods: From August 2013 to April 2018, data patients confirmed who received as because intolerance or unresponsiveness were retrospectively reviewed assess effectiveness...
Dengue virus (DENV) infection triggers the activation of autophagy to facilitate viral replication cycle from various aspects. Although a number stimulators are proposed activate autophagy, none them appears prior uncoating process. Given that T-cell immunoglobulin and mucin domain 1 (TIM-1) receptor is putative DENV promotes apoptotic body clearance by induction, it raises possibility TIM-1 may participate in DENV-induced autophagy. In this study, confocal images first revealed...