A5035164752- HIV/AIDS Research and Interventions
- Hepatitis B Virus Studies
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Hepatitis C virus research
- HIV, Drug Use, Sexual Risk
- HIV-related health complications and treatments
- Liver Disease Diagnosis and Treatment
- Vaccine Coverage and Hesitancy
- Pneumocystis jirovecii pneumonia detection and treatment
- SARS-CoV-2 and COVID-19 Research
- Tuberculosis Research and Epidemiology
- COVID-19 Clinical Research Studies
- Antibiotic Use and Resistance
- Infectious Diseases and Tuberculosis
- Antibiotic Resistance in Bacteria
- Influenza Virus Research Studies
- Liver Disease and Transplantation
- Hepatitis Viruses Studies and Epidemiology
- Streptococcal Infections and Treatments
- Urinary Tract Infections Management
- Pneumonia and Respiratory Infections
- Nosocomial Infections in ICU
- Bacterial Identification and Susceptibility Testing
- Malaria Research and Control
İstanbul Başakşehir Çam ve Sakura Şehir Hastanesi
2023-2025
University of Health Sciences Antigua
2022-2025
Sağlık Bilimleri Üniversitesi
2013-2024
Istanbul Metropolitan Municipality
2022-2024
Sema Hospital
2024
Şişli Etfal Eğitim ve Araştırma Hastanesi
2013-2022
Ministry of Health
2014
Yenişehir Hospital
2013
Memorial Sisli Hospital
2012
Izmir University
2008
Background: BICtegravir Single Tablet Regimen (BICSTaR) is an observational cohort study evaluating the effectiveness and safety of bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) in treatment-naïve (TN) treatment-experienced (TE) people with HIV. Objective: To present final pooled 24-month outcomes for full cohort. Methods: Prospective data were from TN TE adults HIV initiating B/F/TAF routine clinical practice across 14 countries (data collection: 25/06/2018–29/12/2023). Outcomes...
BackgroundThe aim of this study was to delineate mortality indicators in pneumococcal meningitis with special emphasis on therapeutic implications.MethodsThis retrospective, multicenter cohort involved a 15-year period (1998–2012). Culture-positive cases (n = 306) were included solely from 38 centers.ResultsFifty-eight patients received ceftriaxone plus vancomycin empirically. The rest given third-generation cephalosporin alone. Overall, 246 (79.1%) isolates found be penicillin-susceptible,...
Leptospirosis is an infectious disease caused by pathogenic leptospires and may vary in degree from asymptomatic infection to severe fatal illness. Sixteen patients (all males; aged 40+/-17 years) with leptospirosis were admitted Sişli Etfal Training Research Hospital between July 1998 August 2003 retrospectively reviewed. Age, gender, occupation, clinical presentation, laboratory features, seasonal distribution of the disease, diagnostical approach, prognostic factors evaluated. Eleven...
The aim of the study was to report epidemiological profile HIV-1 positive patients from, Istanbul, Turkey, which has one lowest HIV-1/AIDS prevalences in Europe. were followed by ACTHIV-IST group established Infectious Diseases Departments five teaching hospitals (three university and two public hospitals) Turkey. HIV-1positive added standard patient files all centers; these then transferred database Internet. A total 829 naiv-untreated chosen from database. number male 700 (84.4%) mean age...
The purpose of this study was to evaluate compliance with guidelines in surgical prophylaxis (SP) procedures Turkey.A point prevalence involving 4 university, 5 education and research 7 public hospitals performed assessing for antibiotic use SP. Compliance based on the "Clinical Practice Guidelines Antimicrobial Surgery (CPGAS) 2013" guideline.Sixteen centers were included study, 166 operations at these being evaluated. Parenteral SP applied 161 (96.9%) these. Type inappropriate 66 (40.9%)...
Hepatitis B virus (HBV) infection is a health problem worldwide. Current treatment options for chronic hepatitis (CHB) are nucleoside or nucleotide analogues and pegylated interferons. Tenofovir entecavir much more commonly used as they have better efficacy, tolerability, high genetic barriers to resistance.The aim of this study was assess the efficacies tenofovir in previously untreated CHB patients cohort.We included cohort including HBeAg-positive HBeAg-negative from 10 centers Istanbul,...
The fatality attributed to pandemic influenza A H1N1 was not clear in the literature. We described predictors for related infection among hospitalized adult patients. This is a multicenter study performed during [A(H1N1)pdm09] outbreak which occurred 2009 and 2010. Analysis laboratory confirmed Multivariate analysis of fatality. In second wave pandemic, 848 patients were because suspected influenza, 45 out (5.3%) died, with 75% fatalities occurring within first 2 weeks hospitalization. Among...
Rate of coinfection with human immunodeficiency virus (HIV) and hepatitis C (HCV) varies in different countries. This may be attributable to common transmission routes as well social, economic, cultural factors.The purpose this study was investigate the prevalence risk factors HCV infection among HIV-positive patients Istanbul, Turkey.Since January 2006 November 2013, 949 that were enrolled by ACTHIV-IST (Action Against HIV Istanbul) Study Group, which consists five centers follow up...
Late presentation of the patients with human immunodeficiency virus (HIV) infection is associated less favourable treatment responses, more accelerated clinical progression, and a higher mortality risk. Although HIV prevalence low in Turkey, it steadily increasing information about late among HIV-positives limited. We aimed to analyze status HIV-positive Turkey.All newly diagnosed HIV/AIDS from 2003 2016 were enrolled this study by five dedicated centres Istanbul, Turkey. Demographic data,...
The prevalence of human immunodeficiency virus (HIV) infection is low but it steadily increasing in Turkey. In the current study, we aimed to assess status HIV management with proposed 90–90–90 targets a large cohort Istanbul, included 2382 patients (2082 male, 300 female, mean age was 36.3 ± 11.3 years). Mean CD4 cell count 399 cells/mm 3 and HIV-RNA level 576,235 copies/ml. According modeling by Modeling tool European Center for Diseases Control Software, 72 74% all had been diagnosed 2016...
The frequency and mortality of candidemia remain important. Non-albicans Candida species such as C. auris are increasing.
The safety of vaccines, access to health care, the level community's knowledge and attention physicians play a critical role in rate adult vaccination. This study aims determine immunization pneumococcal, influenza tetanus vaccines among patients their attitudes hospital. is cross-sectional point prevalence survey. who agreed participate were interviewed using questionnaire. Patients' gender, occupation, educational status, income risk factors (immunosuppressed over 65 years old) compared...
Integrase strand transfer inhibitor (INSTI) is a new class of antiretroviral (ARV) drugs designed to block the action integrase viral enzyme, which responsible for insertation HIV-1 genome into host DNA. The aim this study was evaluate first time INSTI resistance mutations in Turkish patients.This conducted Turkey, between April 2013 and 2015 using 169 HIV-1-infected patients (78 ARV naive 91 ARV-experienced patients). Laboratory clinical characteristics were as follows: gender (M/F): 71/7...
This study aimed to examine the changes in HIV demographics over time an exceptionally low prevalence population, with particular emphasis on men who have sex (MSM).A total of 1292 newly diagnosed HIV-positive patients registered ACTHIV-IST Study Group database between 2000 and 2014 were included. The occurring characteristics at initial admission examined retrospectively.A gradual increase number was evident during period; however, it not possible show proportion MSM within population...
Hepatitis A virus (HAV) is a food and water-borne causing clinical (mainly hepatitis) subclinical disease in humans. It important to characterize circulating strains of HAV order prevent infections using efficacious vaccines. The aim this study was the detection characterization Turkey by performing serology, RT-PCR, sequencing phylogenetic analysis.In study, 355 suspected cases were analysed ELISA for presence antibodies HAV. RNA extracted from 54 IgM positive human sera. None suspect...
Maintaining optimal adherence to antiretroviral therapy (ART) is essential for optimizing the management of HIV infection. The aim this study explore ART rates in Turkey. Included were a total 263 HIV-infected patients followed up by ACTHIV-IST (ACTion against Istanbul) Study Group affiliated with four tertiary hospitals. population included 18 years age or older who on over 12 months. Adherence was assessed medication possession ratio (MPR) calculated each patient using data (a list all...
The liver biopsy is the gold standard for determining level of fibrosis in chronic hepatitis B infection (CHBI). Nonetheless, it possible to predict through some noninvasive methods such as scoring (NIS) serum biomarkers obtained from routine blood tests. We aimed evaluate diagnostic accuracy nine NIS detecting advanced CHBI.We reviewed hospital records CHBI cases with between January 2011 and December 2016 retrospectively. Using Ishak method, we classified stage 1-2 mild 3-6 fibrosis....
Human immunodeficiency virus (HIV) characterized by a high genetic variability includes two genotypes namely HIV-1 and HIV-2. A major proportion of the infections worldwide is caused which four groups (M, N, O P). Group M being responsible for HIV pandemic further divided into nine genetically distinct subtypes (A, B, C, D, F, G, H, J, K). Additionally, more than 49 circulating recombinant forms (CRFs) have been recognized up to now. The aim this study was determine subtype characterization...
COVID-19 vaccines are highly protective against severe disease; however, vaccine breakthrough infections resulting in hospitalization may still occur a small percentage of vaccinated individuals. We investigated whether the clinical and microbiological features outcomes were different between hospitalized patients who either fully with Coronovac or not. All had at least one dose Coronavac included study. The oldest unvaccinated comorbidities, during same period, chosen as controls....
Although left ventricular systolic dysfunction (LVSD) is a major cause of morbidity in human immunodeficiency virus (HIV)-infected patients, there limited data on cardiac functions these patients. Compared to the conventional echocardiography, global longitudinal strain (GLS) can detect subclinical myocardial at an earlier stage.In our study, we aimed evaluate using GLS HIV-infected patients and investigate effect cluster differentiation 4 T-cell values LVSD.This prospective, case-control...