A5061073072- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Esophageal Cancer Research and Treatment
- Ear and Head Tumors
- Gastric Cancer Management and Outcomes
- Lung Cancer Research Studies
- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Medical Imaging and Pathology Studies
- Cancer Genomics and Diagnostics
- Oral and Maxillofacial Pathology
- Cancer Immunotherapy and Biomarkers
- Medical Imaging Techniques and Applications
- Myasthenia Gravis and Thymoma
- Cancer Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Head and Neck Surgical Oncology
- Tumors and Oncological Cases
- Cancer and Skin Lesions
- Cancer Mechanisms and Therapy
- Wnt/β-catenin signaling in development and cancer
- Cancer Cells and Metastasis
- Pleural and Pulmonary Diseases
National Taiwan University Hospital
2016-2025
National Taiwan University
2015-2025
Hungkuang University
2024
Boston Sports & Shoulder Center
2023
Taipei Veterans General Hospital
2022
Taipei Medical University Hospital
2022
National Yunlin University of Science and Technology
2009-2017
National Yang Ming Chiao Tung University
2015
Virginia Department of Environmental Quality
2014
Accreditation Council for Graduate Medical Education
2014
IntroductionThe efficacy of pemetrexed-based chemotherapy in patients with advanced lung adenocarcinoma novel ROS proto-oncogene 1, receptor tyrosine kinase gene (ROS1) oncogenic rearrangement is unclear. This study aimed to compare the ROS1-fusion its those having different driver mutations.MethodsWe retrospectively identified who were screened for epidermal growth factor (EGFR) mutations, echinoderm microtubule associated protein like 4 (EML4)–anaplastic lymphoma (ALK) translocation,...
Preoperative differentiation of follicular thyroid carcinoma (FTC) from adenoma (FA) remains an unsolved puzzle. Patients sometimes undergo unnecessary lobectomy for histology confirmation inevitably.In this retrospective study, we propose new gray-scale ultrasonographic (US) features that may help to differentiate FTC FA.Medical charts and US images neoplasms were collected prospectively. Gray-scale including conventional parameters adding tubercle-in-nodule trabecular formation...
We evaluated the real-world efficacy and side effects of afatinib as a first-line therapy for advanced EGFR mutation-positive lung adenocarcinoma. The medical records patients receiving after National Health Insurance reimbursement between May 2014 January 2016 were reviewed, information on patient characteristics treatment courses collected consecutively. Rebiopsy tissue was mutation MET amplification analyses. detected by fluorescence in situ hybridization immunohistochemistry. In total,...
// Min-Shu Hsieh 1, 3, * , Pei-Wen Yang 2, Li-Fan Wong 2 Jang-Ming Lee 1 Department of Pathology, National Taiwan University Hospital and College Medicine, Taipei, Surgery, 3 Graduate Institute University, These authors have contributed equally to this work Correspondence to: Lee, email: jmlee@ntu.edu.tw Keywords: esophageal cancer, squamous cell carcinoma, AXL, HER2, targeted therapy Received: December 06, 2015 Accepted: April 18, 2016 Published: May 9, ABSTRACT Esophageal carcinoma (ESCC)...
Preoperative computed tomography (CT)-guided localization of small lung nodules is important for accurate and efficient video-assisted thoracoscopic surgery (VATS). Resection multiple pulmonary in one VATS procedure can aid patient management. The aim this study was to evaluate the usefulness CT-guided Patent Blue V (PBV) dye patients with who underwent VATS.This retrospective conducted from January 2013 December 2015. One hundred consecutive (59.9±10.5 years age) 217 preoperative PBV (2 4)...
Abstract The tumor microenvironment plays a central role in cancer initiation and progression. CD248 is expressed tumor-associated stromal cells, particularly fibroblasts pericytes. Exploring the function of has potential to provide biological insights into tumor-supportive stroma therapeutic targets. Here, we investigated lung cancer. In orthotopic transplantation models, volume, density vessels pericytes, functionality were all lower mice lacking Cd248 (Cd248LacZ/LacZ) compared with...
Type 2 alveolar epithelial (AT2) cells of the lung are fundamental in regulating inflammation response to injury. Impaired mitochondrial long-chain fatty acid β-oxidation (mtLCFAO) AT2 is assumed aggravate acute injury (ALI), yet importance mtLCFAO cell function needs be defined. Here we show that expression carnitine palmitoyltransferase 1a (CPT1a), a rate limiting enzyme, significantly decreased respiratory distress syndrome (ARDS). In mice, Cpt1a deletion impairs without reducing ATP...
Advanced ScienceVolume 12, Issue 1 2570004 Back CoverOpen Access Mapping Nanoscale-To-Single-Cell Phosphoproteomic Landscape by Chip-DIA (Adv. Sci. 1/2025) Gul Muneer, MuneerSearch for more papers this authorSofani Tafesse Gebreyesus, Sofani GebreyesusSearch authorCiao-Syuan Chen, Ciao-Syuan ChenSearch authorTzu-Tsung Lee, Tzu-Tsung LeeSearch authorFengchao Yu, Fengchao YuSearch authorChih-An Lin, Chih-An LinSearch authorMin-Shu Hsieh, Min-Shu HsiehSearch authorAlexey I. Nesvizhskii, Alexey...
Abstract This case report describes a 60-year-old male patient initially diagnosed with metastatic lung adenocarcinoma harboring an epidermal growth factor receptor (EGFR) exon 21 L858R mutation who subsequently developed rare acquired AGK-BRAF fusion during the course of treatment. highlights complexity managing EGFR-mutant cancer additional genetic alterations, potential role these alterations in treatment resistance, and importance comprehensive genomic profiling guiding personalized strategies.
Background/Objectives: The cobas EGFR test v2, used for detecting mutations, can yield invalid results due to internal control (IC) issues, such as “IC not detected”, out of range: high Ct value”, or low value”. This study aimed examine the incidence and explored mechanism behind IC values. Methods: We retrospectively reviewed cases, linking undetectable values inadequate DNA from small biopsies, determined by conducting a pathological review. Cases with were further tested, hypothesis...