A5043526179- Acute Ischemic Stroke Management
- Diabetes Treatment and Management
- Stroke Rehabilitation and Recovery
- Peripheral Artery Disease Management
- Diabetes Management and Research
- Food Security and Health in Diverse Populations
- Neuroendocrine Tumor Research Advances
- COVID-19 Clinical Research Studies
- Children's Physical and Motor Development
- Pharmaceutical Economics and Policy
- Emergency and Acute Care Studies
- Dysphagia Assessment and Management
- CAR-T cell therapy research
- Retinal Imaging and Analysis
- Cerebrovascular and Carotid Artery Diseases
- Retinal and Optic Conditions
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Lymphoma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Diverticular Disease and Complications
- Tracheal and airway disorders
- Pharmacogenetics and Drug Metabolism
- Obesity, Physical Activity, Diet
- COVID-19 and healthcare impacts
Deakin University
2020-2025
China Medical University
2022-2024
Ministry of Health and Welfare
2022-2023
National Yang Ming Chiao Tung University
2022
National Research Institute of Chinese Medicine
2022
Boehringer Ingelheim (United States)
2021
Boehringer Ingelheim (Germany)
2021
Statistics Finland
2021
Continued expansion of indications for sodium-glucose cotransporter-2 inhibitors increases importance evaluating cardiovascular and kidney efficacy safety empagliflozin in patients with type 2 diabetes compared to similar therapies.The EMPRISE Europe Asia study is a non-interventional cohort using data from 2014-2019 seven European (Denmark, Finland, Germany, Norway, Spain, Sweden, United Kingdom) four Asian (Israel, Japan, South Korea, Taiwan) countries. Patients initiating were 1:1...
GLP-1 receptor agonists and SGLT2 inhibitors are increasingly being used in people with type 2 diabetes on the basis of findings from randomised clinical trials; however, little is known whether outcomes affected by frailty real-world settings. We aimed to compare effectiveness safety managing diabetes, a specific focus stratifying their status.
Abstract Background To estimate the short term (5 years) and long (30 economic burden of stroke among younger adults (18–64 years), to calculate loss health-related quality life in these individuals, Australia. Methods A Markov microsimulation model was built simulate incidence Younger with commenced via health states defined by modified Rankin Scale at 12 months from AVERT study (A Very Early Rehabilitation Trial), transitioned through states. Costs Australian dollars (AUD) were measured a...
Abstract Aims The COVID-19 pandemic disrupted healthcare systems and possibly impacted the management of heart failure (HF). This study examined impact on HF hospitalization activities, outcomes, costs in Victoria, Australia. Methods results Data hospitalizations were acquired from Victorian Admitted Episodes Dataset. All consecutive patients hospitalized for both public private hospitals Victoria between February 2019 March 2021 extracted using International Statistical Classification...
<h3>Importance</h3> Cardiorespiratory fitness is an important marker of childhood health and low levels are a risk factor for disease later in life. Levels children's have declined recent decades. Whether school-based physical activity interventions can increase at the population level remains unclear. <h3>Objective</h3> To evaluate effect internet-based intervention on cardiorespiratory across large number schools. <h3>Design, Setting, Participants</h3> In this cluster randomized clinical...
Objective Stroke telemedicine improves the provision of reperfusion therapies in regional hospitals, yet evidence its cost-effectiveness using patient-level data is lacking. The aim this study was to estimate cost per quality-adjusted life year (QALY) gained from stroke telemedicine. Methods As part Victorian Telemedicine (VST) program, provided 16 hospitals Victoria evaluated a historical-control design. Patient-level costs societal perspective (2018 Australian dollars (A$)) and QALYs up 12...
Few countries have established national programs to maximize access and reduce operational overheads. We aimed use patient-level data up 12 months model the potential long-term costs health benefits attributable implementing such a program for Australia. A Markov was created Australia with an inception population of 10,000 people stroke presenting non-urban or suburban hospitals without medical specialists that could receive telemedicine under program. Seven states represented seven modified...
Abstract Background Studies that have reported lower risk for cardiovascular outcomes in users of Sodium–Glucose Cotransporter-2 Inhibitors (SGLT-2i) are limited by residual cofounding and lack information on prior disease (CVD). This study compared events patients within routine care settings Europe Asia with type 2 diabetes (T2D) initiating empagliflozin to dipeptidyl peptidase-4 inhibitors (DPP-4i) stratified pre-existing CVD history heart failure (HF). Methods results Adults DPP-4i...
Herbal interactions with nifedipine/felodipine through cytochrome P450 (CYP) 3A inhibition is significant in humans. Shengmai-San (SMS), a three-herbal formula of Chinese medicine, commonly prescribed Asia populations for cardiovascular disorders. This study aimed to elucidate the impact SMS on treatment by findings from rat pharmacokinetic nifedipine retrospective cohort patients hypertension. The 3-week increased systemic exposure nearly two-fold and decreased clearance 39% rats. Among...
GlideScope-assisted nasotracheal intubation (NTI) has been proposed as an alternative to difficult orotracheal for critical patients or those under cervical immobilization. We evaluated the difficulty of performing NTI using GlideScope orthosis. A total 170 scheduled elective spinal surgery that required were randomized receive immobilization a collar (collar group) no at all (control before anesthetic induction (group assignment 1:1 ratio). All during performed GlideScope. The primary...
Background and Aims: Disability-adjusted life years (DALYs) are an important measure of the global burden disease that informs patient outcomes policy decision-making. Our study aimed to compare DALYs saved by endovascular thrombectomy (EVT) in Australasian-based EXTEND-IA trial vs. clinical registry data from EVT Australian routine practice. Methods: The 3-month modified Rankin scale (mRS) outcome treatment status consecutively enrolled patients with large vessel occlusion (LVO) stroke were...
Objectives: This study sought to establish the cost-effectiveness of endovascular thrombectomy (EVT) in M2 occlusions compared with patients who did not have EVT using both real-world and clinical trial evidence. Methods: The effectiveness was informed by International Stroke Perfusion Imaging Registry (INSPIRE, data for a wide range strokes) HERMES collaboration, data. Patients received non-EVT treatment from INSPIRE were matched according baseline characteristics. A Markov model 7 health...
Introduction: Telemedicine can address limited access to medical specialists in rural hospitals. Stroke provides an important case study because: it is a major cause of disease burden; effective treatments reduce disability (e.g., thrombolysis) be provided within the initial hours stroke onset; careful selection patients needed by skilled doctors minimize adverse events from thrombolysis; and there are treatment gaps (only about half regional hospitals Australia provide thrombolysis for...
Surgical retraction to expose the vertebrae during anterior cervical spine surgery increases tracheal tube cuff pressure and may worsen postoperative sore throat dysphonia. This randomized double-blind study investigated effect of shape on intraoperative Eighty patients were intubation with a tapered or conventional cylindrical high-volume low-pressure (control) anesthesia. Intraoperative pressures compared. The primary outcome was incidence adjustment needed when increased > 25 mm Hg after...
Rapid reperfusion in ischaemic stroke with emergent large vessel occlusion (ELVO) reduces morbidity and mortality. Limited distribution of endovascular clot retrieval (ECR) capable comprehensive centres (CSCs) necessitates development pre-hospital models care to provide equitable economical access therapy. We examine the time metrics traditional secondary transfer strategy comparison direct bypass potential utility ACT-FAST prehospital triage algorithm on a volume Melbourne primary centre...
Objectives This study compared transcatheter aortic valve replacement (TAVR) and surgical (SAVR) in terms of short- long-term effectiveness. Methods retrospective cohort based on nationwide National Health Insurance claims data Cause Death focused adult patients ( n = 3,643) who received SAVR (79%) or TAVR (21%) between 2015 2019. Propensity score overlap weighting was applied to account for selection bias. Primary outcomes included all-cause mortality (ACM), hospitalization heart failure, a...
Introduction The gap in bowel cancer screening participation rates between the lowest socioeconomic position (SEP) groups and highest Australia is widening. This study estimates long-term health impacts healthcare costs at current colorectal (CRC) by SEP South (SA). Methods A Markov microsimulation model for each quintile SA estimated outcomes over lifetime of a population aged 50–74 years (total n = 513,000). simulated development CRC, considering National Bowel Cancer Screening Program...
The EMPRISE study evaluates the effectiveness and safety of empagliflozin (EMPA) in a broader population patients with T2D routine clinical care across countries. included 67,140 pairs 1:1 propensity score matched (PSM) ≥18 years newly initiating EMPA or any DPP-4i from large databases/registers Israel, Finland, Germany, Spain, Sweden, South Korea, Taiwan Japan. Mostly, PSM used 100+ baseline covariates (Table), pooled HR 95% CI were computed using random-effects meta-analysis models....