A5046856541- Cardiac Ischemia and Reperfusion
- Photonic and Optical Devices
- Advanced MEMS and NEMS Technologies
- Nitric Oxide and Endothelin Effects
- Semiconductor Lasers and Optical Devices
- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Neuroscience and Neuropharmacology Research
- Calpain Protease Function and Regulation
- Anesthesia and Neurotoxicity Research
- Sirtuins and Resveratrol in Medicine
- Tracheal and airway disorders
- Cervical and Thoracic Myelopathy
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cardiac electrophysiology and arrhythmias
- Acute Ischemic Stroke Management
- Signaling Pathways in Disease
- Dysphagia Assessment and Management
- Mechanical and Optical Resonators
- Metabolism, Diabetes, and Cancer
- Ion channel regulation and function
- Cardiovascular Function and Risk Factors
- Airway Management and Intubation Techniques
- Autophagy in Disease and Therapy
Chung Shan Medical University
2015-2024
Chung Shan Medical University Hospital
2013-2024
Taichung Veterans General Hospital
2024
China Medical University
2010
University of California, Los Angeles
1997-2004
Taipei Veterans General Hospital
2003-2004
National Taiwan University
2001-2004
National Yang Ming Chiao Tung University
2003-2004
University of California System
2003
Tokyo University of Science
2002
There are close links between chemotherapy-induced intestinal mucositis and microbiota dysbiosis. Previous studies indicated that D-methionine was an excellent candidate for a chemopreventive agent. Here, we investigated the effects of on cisplatin-induced mucositis.Male Wistar rats (176-200 g, 6 weeks old) were given cisplatin (5 mg/kg) treated with (300 mg/kg). Histopathological, digestive enzymes activity, oxidative/antioxidant status, proinflammatory/anti-inflammatory cytokines in...
Abstract Human WWOX gene resides in the chromosomal common fragile site FRA16D and encodes a tumor suppressor WW domain-containing oxidoreductase. Loss-of-function mutations both alleles of lead to autosomal recessive abnormalities pediatric patients from consanguineous families, including microcephaly, cerebellar ataxia with epilepsy, mental retardation, retinal degeneration, developmental delay early death. Here, we report that targeted disruption Wwox mice causes neurodevelopmental...
Many studies have shown that crosstalk exists between apoptosis and autophagy, despite differences in mechanisms these processes. Paeonol, a major phenolic compound isolated from Moutan Cortex Radicis, the root bark of Paeonia × suffruticosa Andrews (Paeoniaceae), is widely used traditional Chinese medicine as an antipyretic, analgesic anti-inflammatory agent. In this study, we investigated detailed molecular autophagy underlying cardioprotective effects paeonol rats subjected to myocardial...
No reports exist as to neuroprotective effects associated with topical activation of transient receptor potential melastatin 8 (TRPM8), a noted cold receptor. In the present study, we identified whether activating peripheral TRPM8 can be an adjuvant therapy for ischemic stroke.Menthol, agonist TRPM8, was applied orally or topically all paws back mouse after middle cerebral artery occlusion (MCAO). We used Trpm8 gene knockout (Trpm8-/-) mice antagonist and lidocaine validate roles nerve...
<sec> <title>BACKGROUND</title> With the growing prevalence of aging populations, improving health and quality life older adults has become a critical concern globally. In this context, sports technology presents promising applications. technological advancements, traditional fitness programs may no longer completely address specific needs adults. The exergame-based training mat—an interactive exercise technology—integrates gamification with diverse designs, offering safe engaging approach...
Honokiol, a constituent extracted from Magnolia officinalis, had been shown be an antioxidant and anti-platelet agent in biological systems with anti-arrhythmic effect myocardial protective on ischemia-reperfusion injury. We examined the neuroprotective of honokiol rats subjected to focal cerebral ischemia. Honokiol was administered intravenously either at fifteen minutes before right middle artery occlusion (pretreatment groups) or when both common carotid arteries clips were removed...
Background: Antioxidants effectively reduce ischemia-reperfusion (IR) injury. The cardioprotective effects of luteolin, a flavonoid that exhibits antioxidant properties and is widely available in many fruits vegetables, were examined rats subjected to myocardial IR Methods Results: Rats ischemia or reperfusion injury evaluate the antiarrhythmic luteolin. Myocardial infarct size was determined histochemically with triphenyltetrazolium chloride staining left ventricle. Luteolin administered...
Lumbrokinase is used as an oral supplement to support and maintain healthy cardiovascular function, treat diseases in clinical for more than 10 years. Up until now, the mechanism of cardioprotective effects post-ischemic treatment with lumbrokinase has remained unclear. We therefore investigated signaling pathways involved amelioration myocardial ischemia-reperfusion (I-R) injury rats treated 20 min after ischemia. Compared vehicle-treated rats, was associated significant reductions...
We report on a microelectromechanical-systems (MEMS)-based 1/spl times/N wavelength-selective switch (WSS) with excellent open-loop stability and repeatability. The optical power fluctuation of the WSS is </spl plusmn/0.0035 dB over 3.5-h period. variation during 30 ON-OFF switching periods plusmn/0.0026 dB. Experiments were also performed analog MEMS mirror. repeatability are /spl plusmn/0.00085/spl deg/ plusmn/0.0013/spl deg/, respectively.
Background Ischemic preconditioning (IPC) produces immediate tolerance to subsequent prolonged ischemia/reperfusion (I/R), although the underlying mechanism remains unknown. The purpose of this study was examine role nitric oxide (NO) and protein kinase C (PKC) in IPC-attenuated post ischemic leukocyte - endothelium interactions. Methods Results Male Sprague-Dawley rats were randomized (n=8 per group) into 5 groups: sham-operated control group, IPC I/R group (4 h pubic epigastric artery...
Abstract In this study, we established systemic in-vivo evidence from molecular to organism level explain how diabetes can aggravate myocardial ischemia-reperfusion (I/R) injury and revealed the role of insulin signaling (with specific focus on Akt/GLUT4 molecules). The I/R was induced by left main coronary artery occlusion for 1 hr then 3 reperfusion in control, streptozotocin (STZ)-induced insulinopenic diabetes, insulin-treated diabetic rats. rats showed a significant decrease heart rate,...
Abstract Induced pluripotent stem cell-derived neural progenitor cells (iPSC-NPCs) are a promising source of tailor-made cell therapy for neurological diseases. However, major obstacles to clinical use still exist. To circumvent complications related intracerebral administration, we implanted human iPSC-NPCs epidurally over the peri-infarct cortex 7 days after permanent middle cerebral artery occlusion in adult rats. Compared controls, cell-treated rats showed significant improvements...
The functions of free radicals on the effects insulin that result in protection against cerebral ischemic insult diabetes remain undefined. This present study aims to explain contradiction among nitric oxide (NO)/superoxide/peroxynitrite amelioration focal ischemia-reperfusion (FC I/R) injury streptozotocin (STZ)-diabetic rats and delineate underlying mechanisms. Long-Evans male were divided into three groups (age-matched controls, diabetic, diabetic treated with insulin) or without being...
Ischemic stroke is characterized by the loss of cerebral blood flow, which frequently leads to neurological deficits. Tissue plasminogen activator only therapeutic agent approved treat ischemic but increases risk intracranial hemorrhage and mortality. The fibrinogen-depleting lumbrokinase has been used improve myocardial perfusion in symptomatic stable angina prevent secondary stroke. Lumbrokinase highly fibrin-specific active presence fibrin. Therefore, a low due excessive fibrinolysis. In...