A5089712784- Cutaneous Melanoma Detection and Management
- Carbon dioxide utilization in catalysis
- biodegradable polymer synthesis and properties
- Nonmelanoma Skin Cancer Studies
- Nitric Oxide and Endothelin Effects
- Nuclear Receptors and Signaling
- Genetics and Neurodevelopmental Disorders
- Heart Failure Treatment and Management
- Autoimmune Bullous Skin Diseases
- Ubiquitin and proteasome pathways
- Skin Protection and Aging
- Cutaneous lymphoproliferative disorders research
- Hair Growth and Disorders
- Neuroscience of respiration and sleep
- Skin Diseases and Diabetes
- Advanced Fluorescence Microscopy Techniques
- Hormonal Regulation and Hypertension
- Photoacoustic and Ultrasonic Imaging
- Eosinophilic Disorders and Syndromes
- Renin-Angiotensin System Studies
- Cancer Cells and Metastasis
- Advanced Polymer Synthesis and Characterization
- Cancer and Skin Lesions
- Photodynamic Therapy Research Studies
- Organometallic Complex Synthesis and Catalysis
Chi Mei Medical Center
2012-2023
National Tainan Institute of Nursing
2006-2023
Southern Taiwan University of Science and Technology
2014-2022
Chia Nan University of Pharmacy and Science
2013
Kaohsiung Medical University
1998-2006
National Cheng Kung University
2006
Kaohsiung Chang Gung Memorial Hospital
2006
Chang Gung University
2006
National Cheng Kung University Hospital
2004-2005
Changhua Christian Hospital
2000
Sequencing technologies, such as whole-exome sequencing (WES) and whole-genome (WGS), have been increasingly applied to medical research in recent years. Which countries, journals, institutes (called entities) contributed most the fields (WES/WGS) remains unknown. Temporal bar graphs (TBGs) are frequently used trend analysis of publications. However, how draw TBG on Sankey diagram is not well understood bibliometrics. We thus aimed investigate evolution article entities WES/WGS using...
Background: Hidradenitis suppurativa (HS) is a chronic, inflammatory and debilitating dermatosis characterized by painful nodules, sinus tracts abscesses in apocrine gland-bearing areas that predominantly affect women worldwide. New therapeutic interventions based on the clinical manifestations of patients have recently been introduced numerous articles. However, which countries, journals, subject categories, articles ultimate influence remain unknown. This study aimed to display influential...
Abstract Human WWOX gene resides in the chromosomal common fragile site FRA16D and encodes a tumor suppressor WW domain-containing oxidoreductase. Loss-of-function mutations both alleles of lead to autosomal recessive abnormalities pediatric patients from consanguineous families, including microcephaly, cerebellar ataxia with epilepsy, mental retardation, retinal degeneration, developmental delay early death. Here, we report that targeted disruption Wwox mice causes neurodevelopmental...
Abstract Artesian well‐water had high concentrations of arsenic that led to the well‐known black foot disease in Taiwan around 1950s, and associated cancers including skin cancer, bladder lung cancers. We sought estimate standardized morbidity ratio ( SMR ) age‐standardized incidence rate ASIR cutaneous squamous cell carcinoma SCC basal BCC endemic areas BFDEA Taiwan. A nationwide retrospective population‐based survey was done with data from National Cancer Registry Center between 1979 2007....
The widespread use of phthalates as plasticizers has raised public health concerns regarding their adverse effects, including an association with cancer. Although animal investigations have suggested between phthalate exposure and hepatocellular carcinoma, the mechanisms are unknown. carcinoma cell line Huh7 was treated benzyl butyl (BBP), then analyzed by total internal reflection fluorescence microscopy, confocal microscopy double immunogold transmission electron microscopy. Following BBP...
Pemphigus vulgaris (PV) is a rare autoimmune blistering disease characterized by intraepithelial and mucocutaneous blister formation erosion. Numerous articles related to PV have been published. However, which tremendous influence still unknown, factors affecting article citation numbers remain unclear. We aimed visualize the prominent entities using top 100 most-cited on topic of (T100PV), investigate whether medical subject headings (i.e., MeSH terms) can be used predict citations.By...
Psoriasis Vulgaris is a chronic inflammatory disease characterized by keratinocyte hyperproliferation. Bibliometric analysis helps determine the most influential article on topic of "Psoriasis and biological agents (PVBAs)", what factors affect citation remain unclear. This study aims (1) to identify top 100 cited articles in PVBA (PVBA100 for short) from 1991 2020, (2) visualize dominant entities one diagram using data PVBA100, (3) investigate whether medical subject headings (MeSH terms)...
When COS7 fibroblasts and other cells were exposed to UVC irradiation cold shock at 4°C for 5 min, rapid upregulation nuclear accumulation of NOS2, p53, WWOX, TRAF2 occurred in 10-30 min. By time-lapse microscopy, an enlarging gas bubble containing nitric oxide (NO) was formed the nucleus each cell that finally popped out cause "bubbling death". Bubbling effectively 4 22°C, whereas DNA fragmentation markedly blocked 4°C. temperature increased 37°C, bubbling retarded 1 hr, suggesting death is...
Web-based computerized adaptive testing (CAT) implementation of the skin cancer (SC) risk scale could substantially reduce participant burden without compromising measurement precision. However, CAT SC classification has not been reported in academics thus far.We aim to build a CAT-based model using machine learning develop an app for automatic help patients assess at early stage.We extracted data from population-based Australian cohort study (N=43,794) Rasch simulation scheme. All 30...
Melanoma is a life-threatening form of skin cancer. Due to its remarkable effectiveness, the immune checkpoint blockade widely used treat melanoma (ICBM). No research has been conducted on ICBM for identifying most readable articles. A bibliometric analysis 100 top-cited (T100ICBM) in recent decades required highlight articles worth reading.Based Web Science Core Collection, we summarized published each year from 2000 2022, with first authors Mainland China, Hong Kong, and Taiwan (CHT)....
Using multiphoton microscopy (MPM), we demonstrated that effective inducing of two-photon excited luminescence and second-harmonic generation signals in nano/microparticles clinoptilolite type zeolite (CZ) by femtosecond near-infrared laser excitation can be successfully utilized imaging the drug adsorption processes. Adsorption photodynamic active dyes (hypericin, chlorin e6, methylene blue, fluorescein) their release from CZ pores presence biomolecules, such as collagen bovine Achilles...
Zfra is a 31-amino-acid zinc finger-like protein, which participates in the tumor necrosis factor signaling. Here, we determined that when nude mice and BALB/c were pre-injected with nanogram levels of synthetic Zfra1-31 or truncated Zfra4-10 peptide via tail veins, these became resistant to growth, metastasis stemness melanoma cells, many malignant cancer cells. The peptides underwent self-polymerization phosphate-buffered saline. Alteration Ser8 phosphorylation site Gly8 abolished...
Background Skin cancers are caused by the development of abnormal cells that can invade or spread to other parts body. The countries whose authors contribute most amount articles on skin cancer academia is still unknown. Objective objectives this study apply an author-weighted scheme (AWS) quantify credits for coauthors article byline and allocate author weights country-level in articles. Methods On July 20, 2019, we obtained 16,804 abstracts published since 1938, based a keyword search...
Proapoptotic tumor suppressor WWOX is upregulated in the early stage of cancer initiation, which probably provides limitation to growth and progression. Later, protein reduced enhance cell growth, migration, invasiveness metastasis. To understand how works controlling progression, here we demonstrate that apoptotic stress mediated by ectopic stimulated cells secrete basic fibroblast factor (bFGF) order support capillary microtubule formation. This event may occur initiation stage. when loss...
Pigmented epithelioid melanocytoma (PEM), or animal-type melanoma, is an unusual variant of melanoma which has been reported to have indolent behavior and a relatively good prognosis. We report 12-year-old girl with PEM on the third finger web her right hand. Histopathologically, it was composed heavily pigmented dermal spindled melanocytic tumor cells. A sentinel lymph node biopsy negative, no recurrence noted 1 year later. reviewed 173 previously published cases so-called in literature....
The h-index of a researcher refers to the maximum number h his/her publications that has at least citations via concept square area. x-index is determined by area rectangle under curve interpret authors' individual research achievements (IRAs). However, properties both metrics have not been compared and discussed before. This study aimed investigate whether h- are suitable for evaluating IRAs in short period years.By searching PubMed database (Pubmed.com), we used keyword "PLoS One"...
Trinuclear aluminum complexes bearing bipyrazoles were synthesized, and their catalytic activity for ε-caprolactone (CL) polymerization was investigated. DBu2Al3Me5 exhibited higher than did the dinuclear complex LBu2Al2Me4 (16 times as high CL polymerization; [CL]:[DBu2Al3Me5]:[BnOH] = 100:0.5:5, [DBu2Al3Me5] 10 mM, conversion 93% after 18 min at room temperature). Density functional theory calculations revealed a mechanism in which first approached central Al atom then moved to an external...