A5079599993- Hereditary Neurological Disorders
- Neurological diseases and metabolism
- Genetic Neurodegenerative Diseases
- Genetics and Neurodevelopmental Disorders
- Nuclear Receptors and Signaling
- Amyotrophic Lateral Sclerosis Research
- Peptidase Inhibition and Analysis
- Cellular transport and secretion
- Peroxisome Proliferator-Activated Receptors
- RNA regulation and disease
- Radio Frequency Integrated Circuit Design
- Circular RNAs in diseases
- Signaling Pathways in Disease
- Cancer Mechanisms and Therapy
- Semiconductor Quantum Structures and Devices
- Cerebrovascular and genetic disorders
- Cancer-related Molecular Pathways
- Parkinson's Disease Mechanisms and Treatments
- Prostate Cancer Treatment and Research
- Neurogenetic and Muscular Disorders Research
- GaN-based semiconductor devices and materials
- Ubiquitin and proteasome pathways
- Moyamoya disease diagnosis and treatment
National Yang Ming Chiao Tung University
2018-2023
Taipei Veterans General Hospital
2021-2023
Taichung Veterans General Hospital
2021
Concord Repatriation General Hospital
2021
Anzac Research Institute
2021
The University of Sydney
2021
Yokohama City University
2021
National Cheng Kung University Hospital
2021
National Cheng Kung University
2013-2020
Abstract Human WWOX gene resides in the chromosomal common fragile site FRA16D and encodes a tumor suppressor WW domain-containing oxidoreductase. Loss-of-function mutations both alleles of lead to autosomal recessive abnormalities pediatric patients from consanguineous families, including microcephaly, cerebellar ataxia with epilepsy, mental retardation, retinal degeneration, developmental delay early death. Here, we report that targeted disruption Wwox mice causes neurodevelopmental...
<h3>Background and Objectives</h3> The GGC repeat expansion in the 5′ untranslated region of <i>NOTCH2NLC</i> was recently identified as cause neuronal intranuclear inclusion disease (NIID), which may manifest with peripheral neuropathy. aim this study is to investigate its contribution inherited <h3>Methods</h3> This cohort screened patients molecularly undiagnosed Charcot-Marie-Tooth (CMT) healthy controls for using repeat-primed PCR fragment analysis. clinical electrophysiologic features...
The survival of prostate cancer (PrCa) patients is associated with the transition to hormone-independent tumor growth and metastasis. Clinically, dysregulation androgen action has been formation PrCa outcome deprivation therapy in PrCa. CCAAT/enhancer binding protein delta (CEBPD) a transcription factor that reported act as an oncogene or suppressor, depending on extra- intracellular environments following tumorigenesis. We found can activate CEBPD by direct receptor (AR) promoter region....
Recent studies have demonstrated that transforming growth factor beta (TGF-β1)-induced antiapoptotic (TIAF1) is able to form aggregates in the hippocampi of middle-aged normal individuals. The aggregating TIAF1 induces generation amyloid (Aβ) for causing neurodegeneration. Intriguingly, are shown, together with Smad4 and Aβ, cancer stroma peritumor capsules many solid tumors. During lung progression, example, fibrils significantly upregulated stroma. Aggregates Aβ shown on interface between...
Abstract Objective Hereditary spastic paraplegias (HSPs) are a group of inherited neurodegenerative disorders characterized by slowly progressive lower limb spasticity and weakness. HSP type 54 (SPG54) is autosomal recessively caused mutations in the DDHD2 gene. This study investigated clinical characteristics molecular features cohort Taiwanese patients with HSP. Methods Mutational analysis was performed for 242 unrelated The clinical, neuroimaging, genetic biallelic were characterized. A...
Background: Neuronal intranuclear inclusion disease (NIID), caused by GGC (guanine-guanine-cytosine) repeat expansion in NOTCH2NLC , has several clinical and radiological features akin to cerebral small vessel (cSVD). The present study tested the hypothesis that may contribute cSVD. Methods: One hundred ninety-seven unrelated patients with genetically unsolved vascular leukoencephalopathy without NOTCH3 HTRA1 mitochondrial m.3243A>G mutations 730 healthy individuals were screened for...
An X-band high-power amplifier (HPA) based on gallium nitride (GaN) high electron mobility transistors (HEMTs) has been developed for synthetic aperture radar (SAR) applications. A hybrid power combining technique, including microstrip circuits and waveguides, is used to design the HPA. For reducing size, four 50 W GaN HEMTs cascaded with one 1-to-4 divider 4-to-1 combiner form a 4-way combined PCB circuits. combing driving an antenna, two are by magic-T waveguides. The transmission...
Human fragile WWOX gene encodes a candidate tumor suppressor WW domain‐containing oxidoreductase. Previous studies have shown that ectopically overexpressed induces apoptosis in cancer cells and suppresses growth both vitro vivo . Functional suppression of by antisense mRNA, dominant negatives, small interfering RNA protects from necrosis factor, anticancer drugs, UV light, ectopic p53 Interestingly, substantial evidence revealed progression various cancers to pre‐metastatic stage positively...