A5101499496- Muscle Physiology and Disorders
- Pain Mechanisms and Treatments
- Traditional Chinese Medicine Studies
- Exercise and Physiological Responses
- Genetic Neurodegenerative Diseases
- Electronic Health Records Systems
- Acupuncture Treatment Research Studies
- Peripheral Nerve Disorders
- Innovations in Medical Education
- Botulinum Toxin and Related Neurological Disorders
- RNA Interference and Gene Delivery
- Diagnosis and treatment of tuberculosis
- Effects of Vibration on Health
- Retinoids in leukemia and cellular processes
- Cardiovascular and Diving-Related Complications
- Neurological diseases and metabolism
- Restraint-Related Deaths
- Hereditary Neurological Disorders
- Transcranial Magnetic Stimulation Studies
- Cellular transport and secretion
- Reproductive Biology and Fertility
- Epilepsy research and treatment
- Pain Management and Treatment
- Lipid metabolism and disorders
- Liver Disease Diagnosis and Treatment
National Cheng Kung University Hospital
2011-2024
Southern University of Science and Technology
2022
Zhejiang University
2022
First Affiliated Hospital Zhejiang University
2022
Concord Repatriation General Hospital
2021
Taipei Veterans General Hospital
2021
Taichung Veterans General Hospital
2021
Anzac Research Institute
2021
The University of Sydney
2021
Yokohama City University
2021
Abstract Background Satellite glial cells (SGCs) in the dorsal root ganglia (DRG) play a pivotal role formation of neuropathic pain (NP). Sciatic nerve stimulation (SNS) neuromodulation was reported to alleviate NP and reduce neuroinflammation. However, mechanisms underlying SNS DRG remain unclear. This study aimed elucidate mechanism electric reducing NP, focusing on DRG. Methods L5 ligation (NRL) rat model studied. Ipsilateral performed 1 day after NRL. Behavioral tests were assess...
INTRODUCTION: Satellite glial cells (SGCs) in the dorsal root ganglia (DRG) play a pivotal role formation of neuropathic pain (NP). Sciatic nerve stimulation (SNS) neuromodulation was shown to alleviate NP and reduce neuroinflammation. However, mechanisms underlying SNS DRG remain unclear. We hypothesized that following injury, activated SGCs possessed distinct inflammatory anti-inflammatory phenotypes, we termed S1 S2, akin A1 A2 astrocytes, respectively. METHODS: L5 ligation (NRL) rats...
<h3>Background and Objectives</h3> The GGC repeat expansion in the 5′ untranslated region of <i>NOTCH2NLC</i> was recently identified as cause neuronal intranuclear inclusion disease (NIID), which may manifest with peripheral neuropathy. aim this study is to investigate its contribution inherited <h3>Methods</h3> This cohort screened patients molecularly undiagnosed Charcot-Marie-Tooth (CMT) healthy controls for using repeat-primed PCR fragment analysis. clinical electrophysiologic features...
Neuropathic pain (NP) is characterized by abnormal activation of conducting pathways and manifests as mechanical allodynia thermal hypersensitivity. Peripheral nerve stimulation used for treatment medically refractory chronic NP has been shown to reduce neuroinflammation. However, whether sciatic (SNS) therapeutic benefit remains unclear. Moreover, the optimal frequency SNS unknown. To address this research gap, we investigated effect in an acute rodent model.Rats with right L5 root ligation...
Abstract Mammalian sperm motility has traditionally been analyzed to determine fertility using computer-assisted semen analysis (CASA) systems. To develop low-cost and robust male diagnostics, we created a paper-based MTT assay used it estimate motile concentration. When porcine was inhibited enzyme inhibitors for enzymes related mitochondrial activity glycolysis, simultaneously recorded enzymatic reactivity portable system (iSperm) assay, respectively. our MTT-assay, calculated the area...
Abstract Technologies for gene activation are valuable tools the study of functions and have a wide range potential applications in bioengineering medicine. In contrast to existing methods based on recruiting transcriptional modulators via DNA-binding proteins, we developed strategy termed Narta ( na scent R NA-guided t ranscriptional ctivation) achieve by artificial transcription factors (aTFs) sites through nascent RNAs target gene. Using Narta, demonstrate robust broad exogenous...
Stimulated by retinoic acid gene homolog 6 (STRA6) and receptor responder 2 (RARRES2) are candidate genes involved in the pathogenesis of type diabetes mellitus (T2DM). Three tag-SNPs STRA6 one RARRES2 were selected genotyped with TaqMan or PCR-RFLP method 603 populations (571 patients T2D versus 632 control subjects) Southern Han Chinese. We estimated interactions between T2DM risk genetic variants using polymerase chain reaction. Rs736118 significantly associated occurrence recessive...
The advent of precision manufacturing has enabled the creation pores in metallic scaffolds with feature size range single microns. In orthopedic implants, pore geometries at micron scale could regulate bone formation by stimulating osteogenic differentiation and coupling osteogenesis angiogenesis. However, biological response to geometry cellular level is not clear. As cells are sensitive curvature boundary, this study aimed investigate high- vs low-curvature environments utilizing computer...
Previous studies have assessed note quality and the use of electronic medical record (EMR) as a part training. However, generalized user-friendly assessment tool is required for quick clinical assessment. We held writing competition developed checklist assessing participants' records. Using checklist, this study aims to explore between residents different specialties offer pedagogical implications.The authors created an inpatient that examined fundamental EMR requirements through six types...
Abstract Denervation of skeletal muscles results in loss muscle mass and contractile force. Recent evidence suggests that local immune system activation plays a key role these processes, but the mechanisms underlying muscle–immune cross‐talk are not understood. The purpose this study was to address by which responds denervation elucidate specific played FYN activation. We studied initial events taking place gastrocnemius wild‐type Fyn −/− mice following sciatic nerve transection....
The main purpose of this study was to investigate the applicability frequency domain analysis on laser Doppler flowmetry (LDF) data recorded from index fingers patients with carpal tunnel syndrome (CTS) and diabetic polyneuropathy (DPN). Patients numbness palm were recruited grouped according results electrophysiological examinations into 2×2 groups by existence or nonexistence CTS and/or DPN. Skin blood perfusion LDF in both neutral position maximally flexed (the Phalen test)....
Denervation of skeletal muscles initiates a cascade cellular events that can lead to muscle atrophy, however, the underlying mechanism is controversial.In present study, by using techniques including real-time PCR, immunoblotting, fluorescent in situ hybridization, and enzyme-linked immunosorbent, we demonstrated VEGFR2 was distinctively cross-linked with MyHCI gastrocnemius, MyHC2B soleus, which likely responsible for activation receptor tyrosine kinases growth factor receptor-bound 2,...
Case Description A 90-year-old man with a 5-year history of ESKD presented sudden coma and quadriplegia. It turned out that the patient had cut his long-term hemodialysis catheter, lumens were exposed directly to air. 1-minute epileptic myoclonus occurred 7 hours later, occasional tremors followed. Brain computer tomography showed multiple air emboli in bilateral brain hemispheres, especially right basal ganglia vessels over cerebral surface. Clusters bubbles also seen superior sagittal...
Intravenous delivery of oncolytic virus (OVs) is promising in cancer treatment. Unfortunately, fast clearance OVs and the severe cytokine release syndrome impedes its wide application. It has been shown that nanoparticles coated with cell membranes display less toxicity slower clearance. However, different from conventional nanoparticles, characteristic spike-like structure abundant antigens on surface make it difficult for intravenous-delivered to take advantage membrane coating shield .To...
Fyn kinase-dependent cellular events were related with skeletal muscle denervation. In the present study, we used a combination of techniques to measure ER stability and Gβ1γ2 trafficking following mobilization, demonstrated temporally Fyn-dependent up-regulation Ca2+ level in mobilized muscle. parallel, activity was gradually decreased, which accompanied by enhanced PTP1B expressions proteins (calnexin, Grp94, cyclophilin, Hsp70). Moreover, during there more membrane protein breakdown than...
Objective To investigate the clinical efficacy and safety of tradition Chinese medicine (TCM) differentiation therapy for treatment diabetes.Methods 46 cases diabetes in our hospital were randomly divided into control group observation group.The was given traditional western treatment.The received TCM therapy.The fasting plasma glucose,total effective rate adverse reactions two groups compared.Results The glucose significantly better than that (P ＜ 0.05).The total 95.7％,which higher 65.2％...