A5019037246- Cardiac Ischemia and Reperfusion
- Calpain Protease Function and Regulation
- Autophagy in Disease and Therapy
- Signaling Pathways in Disease
- Sirtuins and Resveratrol in Medicine
- Endoplasmic Reticulum Stress and Disease
- Phytochemistry and Biological Activities
- Plant and Biological Electrophysiology Studies
- Ion channel regulation and function
- Phytochemistry and Bioactivity Studies
- Genomics and Phylogenetic Studies
- Cellular Mechanics and Interactions
- Adenosine and Purinergic Signaling
- Nicotinic Acetylcholine Receptors Study
- Cancer therapeutics and mechanisms
- DNA Repair Mechanisms
- CRISPR and Genetic Engineering
- GDF15 and Related Biomarkers
- Fatty Acid Research and Health
- Diamond and Carbon-based Materials Research
- Ion Channels and Receptors
- Neuroinflammation and Neurodegeneration Mechanisms
- Enzyme Structure and Function
- Bioactive natural compounds
- Sleep and Wakefulness Research
Chia Nan University of Pharmacy and Science
2023-2024
Chung Shan Medical University
2008-2024
China Medical University
2021
National Yang Ming Chiao Tung University
2012-2019
National Yang Ming University Hospital
2012
University of California, San Diego
1994
Many studies have shown that crosstalk exists between apoptosis and autophagy, despite differences in mechanisms these processes. Paeonol, a major phenolic compound isolated from Moutan Cortex Radicis, the root bark of Paeonia × suffruticosa Andrews (Paeoniaceae), is widely used traditional Chinese medicine as an antipyretic, analgesic anti-inflammatory agent. In this study, we investigated detailed molecular autophagy underlying cardioprotective effects paeonol rats subjected to myocardial...
No reports exist as to neuroprotective effects associated with topical activation of transient receptor potential melastatin 8 (TRPM8), a noted cold receptor. In the present study, we identified whether activating peripheral TRPM8 can be an adjuvant therapy for ischemic stroke.Menthol, agonist TRPM8, was applied orally or topically all paws back mouse after middle cerebral artery occlusion (MCAO). We used Trpm8 gene knockout (Trpm8-/-) mice antagonist and lidocaine validate roles nerve...
Lumbrokinase is used as an oral supplement to support and maintain healthy cardiovascular function, treat diseases in clinical for more than 10 years. Up until now, the mechanism of cardioprotective effects post-ischemic treatment with lumbrokinase has remained unclear. We therefore investigated signaling pathways involved amelioration myocardial ischemia-reperfusion (I-R) injury rats treated 20 min after ischemia. Compared vehicle-treated rats, was associated significant reductions...
The carnivorous pitcher plants of the genus Nepenthes exhibit many ethnobotanical uses, including treatments stomachache and fever. In this study, we prepared different extracts from pitcher, stem, leaf miranda obtained using 100% methanol analyzed their inhibitory effects on recombinant single-stranded DNA-binding protein (SSB) Klebsiella pneumoniae (KpSSB). SSB is essential for DNA replication cell survival thus an attractive target potential antipathogen chemotherapy. Different Sinningia...
The incidence of myocardial ischemia-reperfusion (IR) injury is rapidly increasing around the world and this disease a major contributor to global morbidity mortality. It known that regulation programmed cell death including apoptosis autophagy reduces impact IR injury. In study, cardioprotective effects underlying mechanisms Phellinus linteus (Berk. Curt.) Teng, Hymenochaetaceae (PL), type medicinal mushroom, were examined in rats subjected left main coronary artery was ligated for 1 h...
Ischemic stroke is characterized by the loss of cerebral blood flow, which frequently leads to neurological deficits. Tissue plasminogen activator only therapeutic agent approved treat ischemic but increases risk intracranial hemorrhage and mortality. The fibrinogen-depleting lumbrokinase has been used improve myocardial perfusion in symptomatic stable angina prevent secondary stroke. Lumbrokinase highly fibrin-specific active presence fibrin. Therefore, a low due excessive fibrinolysis. In...
Myocardial ischemia/reperfusion (I/R) injury is marked by rapid increase in inflammation and not only results myocardial apoptosis but also compromises the function. Dunaliella salina (D. salina), a halophilic unicellular microalga, has been used as provitamin A carotenoid supplement color additive. Several studies have reported that D. extract could attenuate lipopolysaccharides-induced inflammatory effects regulate virus-induced response macrophages. However, of on I/R remain unknown....
Carnivorous pitcher plants from the genus Nepenthes are renowned for their ethnobotanical uses. This research explores therapeutic potential of miranda leaf extract against nonstructural protein 9 (Nsp9) SARS-CoV-2 and in treating human non-small cell lung carcinoma (NSCLC) lines. Nsp9, essential RNA replication, was expressed purified, its interaction with ssDNA assessed. Initial tests myricetin oridonin, known targeting ssDNA-binding proteins respectively, did not inhibit activity Nsp9....
Sinningia bullata is a tuberous member of the flowering plant family Gesneriaceae. Prior to this work, antibacterial, antioxidant, and cytotoxic properties S. were undetermined. Here, we prepared different extracts from leaf, stem, tuber investigated their pharmacological activities. The leaf extract bullata, obtained by 100% acetone (Sb-L-A), had highest total flavonoid content, antioxidation capacity, antibacterial Sb-L-A displayed broad range activities against Escherichia coli,...
BACKGROUND After a brief episode of ischemia, myocardial function may be depressed for prolonged periods despite reperfusion. The mechanisms postischemic dysfunction differ depending on the experimental model. Regional ischemia and reperfusion in intact animal provide clinically relevant model, but variables are difficult to control. Experimental conditions can well controlled isolated cardiac muscle myocyte preparations, these models limited by assumptions used mimic This study combines...
Systemic growth differentiation factor 11 (GDF11) treatment improves the vasculature in hippocampus and cortex mice recent studies. However, systemic application of recombinant GDF11 (rGDF11) cannot cross brain blood barrier (BBB). Thus, large doses long-term administration are required, while systemically applied high-dose rGDF11 is associated with deleterious effects, such as severe cachexia. This study tested whether situ low dosage (1 μg/kg) protects against ischemic stroke it...
Single-stranded DNA-binding proteins (SSBs) play a crucial role in DNA metabolism by binding and stabilizing single-stranded (ssDNA) intermediates. Through their multifaceted roles replication, recombination, repair, replication restart, other cellular processes, SSB emerges as central player maintaining genomic integrity. These attributes collectively position SSBs essential guardians of integrity, establishing interactions with an array distinct proteins. Unlike Escherichia coli, which...
Abstract Background Ischemic stroke is characterized by the loss of cerebral blood flow, which frequently leads to neurological deficits. Therefore, minimizing post-stroke functional disability an important research topic. The fibrinogen-depleting agent lumbrokinase has been used improve myocardial perfusion in symptomatic stable angina and prevent secondary ischemic stroke. In this study, we aimed clarify neuroprotection on whether dysfunction. We explored underlying mechanisms C57BL/6 mice...