A5080288920- Spinal Cord Injury Research
- Nerve Injury and Rehabilitation
- Nerve injury and regeneration
- Glioma Diagnosis and Treatment
- Adenosine and Purinergic Signaling
- Neuroblastoma Research and Treatments
- Mesenchymal stem cell research
- Pain Mechanisms and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Urinary Tract Infections Management
- Uterine Myomas and Treatments
- Pituitary Gland Disorders and Treatments
- Glaucoma and retinal disorders
- Diverticular Disease and Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- Sarcoma Diagnosis and Treatment
- Immune cells in cancer
- Endometrial and Cervical Cancer Treatments
- Urinary Bladder and Prostate Research
- Prenatal Screening and Diagnostics
- Silymarin and Mushroom Poisoning
- Biliary and Gastrointestinal Fistulas
- Cervical and Thoracic Myelopathy
- Pelvic floor disorders treatments
- Pluripotent Stem Cells Research
Dongguan People’s Hospital
2025
Southern Medical University
2025
Taipei Veterans General Hospital
2010-2021
National Yang Ming Chiao Tung University
2002-2021
National Yang Ming University Hospital
2009-2021
Taipei Medical University
2003-2019
Central Taiwan University of Science and Technology
2017-2019
Taipei Hospital
2019
Mackay Memorial Hospital
2010-2012
The Neurological Institute
2009
Several lines of evidence have demonstrated that bone marrow-derived mesenchymal stem cells (BM-MSC) release bioactive factors and provide neuroprotection for CNS injury. However, it remains elusive whether BM-MSC derived from healthy donors or stroke patients provides equal therapeutic potential. The present work aims to characterize prepared normal rats (NormBM-MSC) cerebral ischemia (IschBM-MSC), examine the effects their conditioned medium (Cm) on ischemic animal model. Isolated...
Spinal cord injury elicits an inflammatory response that recruits macrophages to the injured spinal cord. Quantitative real-time PCR results have shown a repair strategy combining peripheral nerve grafts with acidic fibroblast growth factor (aFGF) induced higher interleukin-4 (IL-4), IL-10, and IL-13 levels in graft areas of rat cords compared transected at 10 14 d. This led arginase I-positive alternatively activated macrophage (M2 macrophage) responses. The gene expression several enzymes...
Spinal cord injury (SCI) is a devastating neurological condition and might even result in death. However, current treatments are not sufficient to repair such damage. Bone marrow mesenchymal stem cells (BM-MSC) ideal transplantable which have been shown modulate the cascade of SCI mostly through paracrine effects. The present study investigates whether systemic administration conditioned medium from MSCs (MSCcm) has potential be efficacious as an alternative cell-based therapy for SCI. In...
// Wei-Hsiu Liu 1, 2 , Ming-Teh Chen 3, 4, * Mong-Lien Wang 5 Yi-Yen Lee 5, 7, Guang-Yuh Chiou 6 Chian-Shiu Chien 9 Pin-I Huang 8 Yi-Wei Ming-Chao 7 Shih-Hwa Yang-Hsin Shih 4 Hsin-I Ma 1 Graduate Institute of Medical Sciences, National Defense Center, Taipei, Taiwan Department Neurological Surgery, Tri-Service General Hospital and 3 School Medicine, Yang-Ming University, Neurosurgery, Institute, Taipei Veterans & Clinical College Biological Science Technology, Chiao Tung Univeristy,...
Abstract Background and aim Creeping fat (CF) in Crohn's disease (CD) is characterized by hyperplastic mesenteric adipose tissue (MAT) encasing fibrotic intestinal segments. CF exhibits disruptions microbiota lipid metabolism, particularly lysophospholipids (LPC). This study aims to elucidate the impact of LPC on adipogenic differentiation mesenchymal stem cells its effects immune defense functions differentiated adipocytes. Methods Isolated adipocytes MAT from CD Non-CD patients were...
Third trimester amniotic fluid (AF)-derived human mesenchymal stem cells (MSCs) can be greatly expanded in vitro and induced to differentiate into multiple cell types. This study aimed investigate the biological characteristics of MSCs from third AF as a new source therapeutic cells. Forty samples were obtained healthy women who underwent elective caesarean section for breech presentation. A simple culture protocol was used. growth curve drawn, surface antigens cytokines analysed by...
Chemokines can be produced by gliomas, which mediate the infiltration of microglia, a characteristic feature glioma-associated neuropathogenesis. ATP that is released at high level from glioma has been reported to play regulatory role in chemokine production cultured cells. The objective this study was define potential extracellular regulation macrophage inflammatory protein-1α (MIP-1α) and monocyte chemoattractant protein-1(MCP-1) expression microglia/macrophages. results showed Iba1(+)...
In this study, the authors evaluated efficacy of a new surgical strategy for reconnecting injured brachial plexus with spinal cord using fibrin glue containing acidic fibroblast growth factor as an adhesive and neurotrophic agent.Eighteen patients preganglionic injuries, each varying degrees upper limb dysfunction, underwent cervical laminectomy or without sural nerve grafting. The treatment avulsed root varied according to severity injury. Some also second-stage operation involving...
To assess the efficacy of hydrodistention (HD) followed by bladder training (BT) versus HD alone in patients with interstitial cystitis (IC). A total 70 IC were included and randomly assigned to two groups: one treated (HD group) other plus BT group). Each patient was up using a weekly diary for 8 weeks after monthly thereafter 6 months HD. Evaluation parameters age, duration years, how many doctors visited before treatment, urgency, pain, daytime voided volume per void, nocturnal voids day,...
Prostacyclin (PGI2), a potent vasodilator and platelet antiaggregatory eicosanoid, is cytoprotective in cerebral circulation. It synthesized from arachidonic acid (AA) by the sequential action of cyclooxygenase- (COX-) 1 or 2 prostacyclin synthase (PGIS). Because unstable vivo, PGI2 analogs have been developed demonstrated to protect against brain ischemia. This work attempts selectively augment synthesis mixed glial culture model Parkinson's disease (PD) direct adenoviral gene transfer...
The treatment of root injury is typically performed at the more chronic stages post injury, by which time a substantial number neurons have died. Therefore, before being applied in clinical setting, strategy for these lesions should prove to be as effective it acute stage. In this study, we simulated most severe scenarios establish an optimal window repair sixth eighth cervical roots on left side female SD rats were cut their junction with spinal cord. One or three weeks later, wound was...
Nerve root traction injuries induce spinal cord inflammation and lead to neuronal death within days. In the present study, we examined inflammatory response one week after multiple cervical transections.In transection group, left roots (C6-8) of rats were cut at junction. repair transected repaired with nerve grafts subsequent application aFGF fibrin glue. A sham group had exposed without transection. Mechanical allodynia glial responses evaluated.Allodynia did not differ between treatment...
Due to the limited efficacy of chemotherapy, applications adjuvant irradiation play an important role for ependymoma treatment. However, in young ages, resistance residual and recurrent tumor, long-term intellectual sequelae remain major obstacles radiotherapy. Understanding mechanism therapeutic failure caused by radio-resistance is, therefore, crucial Here we retrospectively analyze clinic-pathological factors 82 cases less than 20 years old identify radio-resistant genes through gene...