A5111153694- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Mechanical Circulatory Support Devices
- Blood Pressure and Hypertension Studies
- Renal and Vascular Pathologies
- Abdominal vascular conditions and treatments
- Organ Transplantation Techniques and Outcomes
- Hepatitis Viruses Studies and Epidemiology
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Sodium Intake and Health
- Congenital Diaphragmatic Hernia Studies
- Vascular anomalies and interventions
- Congenital Heart Disease Studies
- Gallbladder and Bile Duct Disorders
- Vascular Malformations and Hemangiomas
- Cardiac Structural Anomalies and Repair
- Cardiac Arrest and Resuscitation
- Lymphatic Disorders and Treatments
- Atrial Fibrillation Management and Outcomes
- Medical Imaging and Pathology Studies
- Vascular Anomalies and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
University of Padua
2016-2025
Universitat Pompeu Fabra
2024
Azienda Ospedaliera di Padova
2018-2023
Research Institute of Radiology
2018-2023
National Taiwan University Hospital
2019
Development Fund
2016
We sought to measure the clinical benefits of adrenal venous sampling (AVS), a test recommended by guidelines for primary aldosteronism (PA) patients seeking surgical cure, in large registry PA submitted AVS. Data 1625 consecutive AVS 19 tertiary referral centers located Asia, Australia, Europe, and North America were collected multicenter international registry. The end points rate bilateral success, ascertained lateralization PA, adrenalectomy, cured arterial hypertension among AVS-guided...
Adrenal venous sampling (AVS) is the key test for subtyping primary aldosteronism (PA), but its interpretation varies widely across referral centers and this can adversely affect management of PA patients.To investigate in a real-life study rate bilateral success identification unilateral their impact on blood pressure outcomes subtyped by AVS.In retrospective analysis largest international registry individual AVS data (AVIS-2 study), we investigated how different cut-off values selectivity...
Abstract Background Portal vein thrombosis (PVT) is the most common thrombotic complication in cirrhosis; however, local risk factors involved its pathogenesis are still not fully investigated. The aim of study was to evaluate hemostasis and endothelial damage portal patients with cirrhosis hypertension. Methods Adult cirrhotics undergoing transjugular intrahepatic portosystemic shunt were consecutively enrolled. Rotational thromboelastometry (ROTEM), dosage total circulating...
Current guidelines and consensus documents recommend withdrawal of mineralocorticoid receptor antagonists (MRAs) before primary aldosteronism (PA) subtyping by adrenal vein sampling (AVS), but this practice can cause severe hypokalemia uncontrolled high blood pressure. Our aim was to investigate if unilateral PA be identified AVS during MRA treatment.
Abstract Primary aldosteronism (PA), the most common cause of arterial hypertension, is surgically curable if a unilateral source hyperaldosteronism discovered. To identify patients who are curable, all current guidelines recommend adrenal venous sampling (AVS), procedure which, albeit simple in principle, remains scarcely available and markedly under-utilized, because it still perceived as technically challenging, invasive, difficult to interpret. The lack uniformly accepted standards for...
Chylothorax is a rare but insidious condition, characterized by the accumulation of chyle in pleural space, which particularly common after cardiothoracic surgeries. It presents significant challenges both diagnosis and treatment. In this technical report, we present our experience managing four cases postsurgical chylothorax, each one treated with different approach. The first second were successfully managed Lipiodol lymphangiography, allowed for visualization occlusion injured lymphatic...
Abstract Context Adrenal gland imaging is recommended by the current guidelines for workup of primary aldosteronism (PA). However, its diagnostic performance has not been established in large, multiethnic cohorts patients who undergo adrenal vein sampling (AVS) and adrenalectomy. Objective This work aims to assess accuracy cross-sectional imaging. Methods international multicenter study took place tertiary referral centers. A total 1625 PA seeking surgical cure were enrolled an involving 19...
Background: The pulsatile secretion of adrenocortical hormones and a stress reaction occurring when starting adrenal vein sampling (AVS) can affect the selectivity also assessment lateralization sequential blood is used. We therefore tested hypothesis that simulated could decrease diagnostic accuracy index for identification aldosterone-producing adenoma (APA), as compared with bilaterally simultaneous AVS. Methods results: In 138 consecutive patients who underwent subtyping primary...
Purpose: Aldosterone-producing adenoma (APA) is the main curable cause of endocrine hypertension primary aldosteronism (PA) and it in up to 66% all cases investigated with adrenal vein sampling (AVS). Mutations KCNJ5 potassium channel involve 70% APA most florid PA phenotypes. The recent finding that macrolide antibiotics specifically inhibit vitro altered function mutated channels has opened new horizons for diagnosis treatment mutations can allow identification target patients harbouring a...
Many of the patients with primary aldosteronism (PA) are denied curative adrenalectomy because limited availability or failure adrenal vein sampling. It has been suggested that sampling can be omitted in young a unilateral nodule, who show florid biochemical PA phenotype. As this suggestion was based on very low quality evidence, we tested applicability and accuracy imaging, performed by computed tomography and/or magnetic resonance, for identification PA, as determined clinical cure after...
BackgroundNeoangiogenesis plays a crucial role in the progression of hepatocellular carcinoma (HCC), and concerns have been raised about neoangiogenesis on effectiveness transarterial chemoembolization (TACE).AimIn this study, we aimed to evaluate Vascular Endothelial Growth Factor (VEGF) Hypoxia-Inducible Factor-1α (HIF-1α) as circulating prognostic biomarkers HCC patients treated with TACE.MethodsBlood samples were collected from 163 before (t0) four weeks after TACE (t1).ResultsHigher...
Success of adrenal vein sampling (AVS) is verified by the selectivity index (SI), i.e., a step-up cortisol levels between and infrarenal inferior vena cava samples, beyond given cut-off. We tested hypothesis that androstenedione, metanephrine, normetanephrine, which have higher gradients than cortisol, could increase rate AVS studies judged to be bilaterally successful usable for clinical decision making. prospectively compared within-patient, head-to-head, androstenedione (SIA),...
Adrenal venous sampling is recommended for the identification of unilateral surgically curable primary aldosteronism but often clinically useless, owing to failed bilateral adrenal vein cannulation.To investigate if only unilaterally selective studies can allow responsible adrenal.Among 1625 patients consecutively submitted in tertiary referral centers, we selected those with results at least one side; used cured as gold reference. The accuracy different values relative aldosterone secretion...
As metoclopramide stimulates aldosterone secretion, we tested its usefulness in the assessment of lateralization primary aldosteronism by adrenal vein sampling (AVS).Prospective within-patient study consecutive patients undergoing AVS for subtyping.We compared diagnostic accuracy baseline and postmetoclopramide index relative (to cortisol) secretion indices (RASI) each gland with aldosterone-producing adenoma (APA) determined four corners criteria as reference diagnosis.We recruited 93 (mean...
There is a lack of consensus on the optimal management fundal gastric varices (GVs) in patients with cirrhosis due to varied anatomy and hemodynamics. In this study, we evaluate safety efficacy trans-splenic anterograde coil-assisted transvenous occlusion (TACATO) for preventing recurrent bleeding GVs associated gastrorenal shunt (GRS). 4-year GRS-associated GV bleeding, without prior esophageal variceal ascites, or portal vein thrombosis, were eligible TACATO. Trans-splenic access was...
Daniele, Andrea; Sabbadin, Chiara; Costa, Giovanni; Vezzaro, Roberto; Battistel, Michele; Saraggi, Deborah; Zattoni, Fabio; Cecchin, Diego; Gardiman, Marina Paola; Betterle, Corrado; Scaroni, Carla; Filiberto; Armanini, DecioAuthor Information