A5055546265- Hormonal Regulation and Hypertension
- Adrenal Hormones and Disorders
- Pharmacological Effects of Natural Compounds
- Adrenal and Paraganglionic Tumors
- Electrolyte and hormonal disorders
- Ion Transport and Channel Regulation
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Ovarian function and disorders
- Stress Responses and Cortisol
- Blood Pressure and Hypertension Studies
- Reproductive Biology and Fertility
- Hormonal and reproductive studies
- Apelin-related biomedical research
- Sperm and Testicular Function
- Endometriosis Research and Treatment
- Pregnancy and preeclampsia studies
- Sodium Intake and Health
- Estrogen and related hormone effects
- Birth, Development, and Health
- Pituitary Gland Disorders and Treatments
- Sexual Differentiation and Disorders
- Vitamin K Research Studies
- Thyroid Disorders and Treatments
- Diet and metabolism studies
- Uterine Myomas and Treatments
University of Padua
2015-2024
Institute of Endocrinology
2002
University of Pavia
2000
Ospedale Maggiore
1995
Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
1995
University of Verona
1994-1995
Weatherford College
1995
Collège de France
1994
Inserm
1994
München Klinik
1985-1991
Liquorice abuse causes a syndrome of pseudohyperaldosteronism. Much less commonly, glucocorticoid-like effects have been reported. The electrolyte-active principle liquorice is glycyrrhizic acid (GI), which can be hydrolyzed to glycyrrhetinic (GE). Previous studies reported that GE, but not GI, may occupy mineralocorticoid and glucocorticoid receptors. We here report both GE GI bind affinity for receptors four orders magnitude lower than aldosterone five dexamethasone. affinity, though low,...
The long-term surgical cure rate of patients with primary aldosteronism varies widely, and causes persistent hypertension are not completely established. We reviewed retrospectively charts from 98 (range, 19-70 years old) aldosterone-producing adenomas who underwent unilateral adrenalectomy. At a median follow-up 81 months 18-186 months), the mean blood pressure values improved in 95 out (96.9%) patients, although was cured only 71 (72.4%) patients. Multivariate analysis using logistic...
There is increasing evidence that the abdominal obesity phenotype may be associated with multiple alterations of hypothalamic-pituitary-adrenocortical (HPA) axis activity in both sexes. Our hypothesis lack adequate cortisol suppression after dexamethasone test constitute an indirect marker HPA hyperactivity presence phenotype. A total 34 normal-weight (13 men and 21 women) 87 obese (36 51 women), healthy, nondepressed subjects therefore underwent four different tests randomly performed at...
Aldosterone binding sites in human mononuclear leukocytes were characterized after separation of cells from blood by a Percoll gradient. After washing and resuspension RPMI-1640 medium, incubated at 37 degrees C for 1 h with different concentrations [3H]aldosterone plus 100-fold concentration RU-26988 (11 alpha, 17 alpha-dihydroxy-17 beta-propynylandrost-1,4,6-trien-3-one), or without an excess unlabeled aldosterone. binds to single class receptors affinity 2.7 +/- 0.5 nM (means SD, n = 14)...
Pseudohypoaldosteronism, a syndrome characterized by salt wasting and failure to thrive, usually presents in infancy as high urinary levels of sodium despite hyponatremia, hyperkalemia, hyperreninemia, elevated aldosterone levels. We have investigated this for the possibility abnormal Type I or "mineralocorticoid-like" receptors, which intrinsic steroid specificity indistinguishable from that renal mineralocorticoid receptors are found many tissues cells, including mononuclear leukocytes....
Possibly due to a deficiency of insulin mediators, polycystic ovary syndrome (PCOS) is often associated with resistance (IR) and hyperinsulinemia, likely responsible for an elevated production reactive oxygen species. We investigated oxidative-related alterations in erythrocytes anti-inflammatory effects inositol women PCOS before after treatment myo-inositol (MYO).Twenty-six normal-weight patients were MYO administration (1200 mg/day 12 weeks; n=18) or placebo (n=8) by evaluating serum...
Current guidelines recommend use of the aldosterone-renin ratio (ARR) for case detection primary aldosteronism followed by confirmatory tests to exclude false-positive results from further diagnostic workup. We investigated hypothesis that this could be unnecessary in patients with a high ARR value if quantitative information carried is taken into due consideration.We interrogated 2 large data sets prospectively collected studied same predefined protocol, which included captopril challenge...
Abstract Aldosterone excess can produce heart and kidney fibrosis, which seem to be related a direct effect of aldosterone at the level specific receptors. We report direct, mineralocorticoid-mediated on protein expression two markers oxidative stress after incubation mononuclear leukocytes with 1 × 10−8m (p22phox/β-actin = 1.38 ± 0.05 PAI-1/β-actin 1.80 0.05). The same was also found 3 10−5m glycyrrhetinic acid, principal constituent licorice root 1.37 0.97 0.04). both acid is blocked by...
We have analyzed the human mineralocorticoid receptor (hMR) gene in 14 families with autosomal dominant or sporadic pseudohypoaldosteronism (PHA1), a rare form of resistance characterized by neonatal renal salt wasting and failure to thrive. Six heterozygous mutations were detected. Two frameshift exon 2 (insT1354, del8bp537) one nonsense mutation 4 (C2157A, Cys645stop) generate truncated proteins due premature stop codons. Three missense (G633R, Q776R, L979P) differently affect hMR...
The influence of thyroid autoimmunity in assisted reproductive technology (ART) outcome euthyroid women is still controversial. In this study, we retrospectively evaluated embryo quality 123 undergoing ART with or without autoantibodies (TAA). Embryo was assessed 119 embryos 29 infertile patients TAA and 394 94 TAA. Our results showed not statistically significant differences age, body mass index, anti-Müllerian hormone, follicle stimulating free triiodothyronine, thyroxine levels between...
Hyperactivity of 5 alpha-reductase in the skin is considered a major mechanism excessive hair growth hirsute women with normal levels serum androgens (idiopathic hirsutism). Preventing conversion testosterone to dihydrotestosterone by inhibiting activity could thus be most rational and effective treatment this condition. The present study evaluated effects oral administration finasteride (5 mg once daily) for 6 months 17 young idiopathic hirsutism, whom were also given an contraceptive....