A5035303356- Hormonal Regulation and Hypertension
- Adrenal Hormones and Disorders
- Adrenal and Paraganglionic Tumors
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Electrolyte and hormonal disorders
- Apelin-related biomedical research
- Ion Transport and Channel Regulation
- Pituitary Gland Disorders and Treatments
- Adipose Tissue and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Immune Cell Function and Interaction
- Cell Adhesion Molecules Research
- Platelet Disorders and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Diabetes Treatment and Management
- Stress Responses and Cortisol
- Bone Tumor Diagnosis and Treatments
- Diabetes Management and Research
- Eicosanoids and Hypertension Pharmacology
- TGF-β signaling in diseases
- Sexual Differentiation and Disorders
- Thyroid Disorders and Treatments
- Hormonal and reproductive studies
- Potassium and Related Disorders
- Tumors and Oncological Cases
Ospedali Riuniti di Ancona
2000-2024
University of Padua
2003-2016
University of Turin
2016
Marche Polytechnic University
2006-2015
Ospedali Riuniti Umberto I
2000-2014
University of Regensburg
2013
Aarhus University
2013
University of Pisa
2013
Leiden University
2010
Universidade Federal do Rio Grande do Sul
2010
Primary aldosteronism (PA) causes cardiovascular damage in excess to the blood pressure elevation, but there are no prospective studies proving a worse long-term prognosis adrenalectomized and medically treated patients. We have, therefore, assessed outcome of PA patients according treatment mode PAPY study (Primary Aldosteronism Prevalence Hypertension) patients, 88.8% whom were optimally with primary (essential) hypertension (PH), rest had assigned medical therapy (6.4%) or adrenalectomy...
Primary aldosteronism (PA) is characterized by the onset of both cardiac and gluco-metabolic alterations. The aim this study was to evaluate impact aldosterone excess on development such complications, effects surgical pharmacological treatment their long-term outcome.We prospectively re-examined 61 patients: 25 with aldosterone-producing adenoma (APA), after surgery, 36 patients idiopathic hyperaldosteronism (IHA) treatment. lipid, fasting dynamic glucose profiles echocardiographic...
Aldosterone-producing adenomas (APAs) cause a sporadic form of primary aldosteronism and somatic mutations in the KCNJ5 gene, which encodes G-protein–activated inward rectifier K + channel 4, GIRK4, account for ≈40% APAs. Additional APA were identified recently 2 other genes, ATP1A1 ATP2B3 , encoding Na /K -ATPase 1 Ca 2+ 3, respectively, at combined prevalence 6.8%. We have screened 112 APAs known hotspots genetic alterations associated with aldosteronism. Somatic present 6.3%, 0.9%, 39.3%...
The upright serum aldosterone/upright plasma renin activity ratio (ARR) has been recommended as a screening tool for the diagnosis of primary aldosteronism.We reviewed data collected from hypertensive patients in order to define retrospectively cut-off values and evaluate reliability ARR saline infusion test aldosteronism.In 157 referred our unit with suspicion aldosteronism, 61 whom had confirmed aldosteronism [26 aldosterone-producing adenoma (APA); 35 idiopathic hyperaldosteronism],...
Current guidelines recommend use of the aldosterone-renin ratio (ARR) for case detection primary aldosteronism followed by confirmatory tests to exclude false-positive results from further diagnostic workup. We investigated hypothesis that this could be unnecessary in patients with a high ARR value if quantitative information carried is taken into due consideration.We interrogated 2 large data sets prospectively collected studied same predefined protocol, which included captopril challenge...
Adrenal vein sampling (AVS) is the only reliable means to distinguish between aldosterone-producing adenoma and bilateral adrenal hyperplasia, two most common subtypes of primary aldosteronism (PA). AVS protocols are not standardized vary widely centers.The objective study was retrospectively investigate whether presence contralateral (CL) suppression aldosterone secretion associated with improved postoperative outcomes in patients who underwent unilateral adrenalectomy for PA.The carried...
To evaluate the expression of 11beta-hydrxysteroid dehydrogenase type 1 (11beta-HSD1) in omental adipose tissue patients with Cushing's syndrome and simple obesity, compared normal weight controls.We have performed a case-control study studied from total 24 subjects (eight obese subjects, ten due to adrenal adenoma, six controls). Body mass index, blood pressure, plasma glucose, insulin, cortisol, urinary free cortisol post dexamethasone were measured standard methods. 11beta-HSD1 mRNA...
Background: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a novel class of incretin mimetics for treating type 2 diabetes (T2D). This study evaluated the impact semaglutide, first oral GLP-1RA, on glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), and body composition anthropometric parameters. Additionally, effects cardiovascular risk factors quality life (QoL) in T2D patients were assessed. Methods: A prospective observational with six-month follow-up was conducted....
The mineralocorticoid receptor (MR) is essential in the regulation of volemia and blood pressure. Rare mutations MR gene cause type 1 pseudohypoaldosteronism hypertension. In this study we characterized common polymorphism c.-2G>C (rs2070951) vitro tested its influence on parameters related to pressure renin-angiotensin system. studies showed that G allele was associated with decreased protein levels reduced transcriptional activation compared C allele. Association were performed several...
Several clinical and experimental lines of evidence have highlighted the detrimental effects visceral adipose tissue excess on cardiometabolic parameters. Besides, recent findings shown gluco-and mineralocorticoid hormones also underscored interplay existing between such adrenal steroids their respective receptors in modulation biology. While fundamental role played by glucocorticoids adipocyte differentiation storage was already well known, relevance mineralocorticoids physiology organ is...
Mutations in the gene encoding 11beta-hydroxysteroid dehydrogenase type 2, 11beta-HSD2 (HSD11B2), explain molecular basis for syndrome of apparent mineralocorticoid excess (AME), characterized by severe hypertension and hypokalemic alkalosis. Cortisol is offending AME, as result a lack 11beta-HSD2-mediated cortisol to cortisone inactivation. In this study, we describe mutations HSD11B2 3 additional AME kindreds which probands presented adult life, with milder phenotypes including original...
The HSD11B2 gene, encoding the kidney isoenzyme 11beta-hydroxysteroid dehydrogenase, is a candidate for essential hypertension. We previously showed that frequency of shorter alleles CA repeat polymorphism in first intron 11beta-HSD2 gene was significantly higher among salt-sensitive than salt-resistant individuals with aim study to analyze assess whether some its variants might be involved hypertension.Exons 2, 3, 4, and 5 were screened by polymerase chain reaction-single-strand...
The hepatitis C virus (HCV) binds to human cells through the interaction of its envelope glycoprotein E2 with tetraspanin CD81. We have previously reported that engagement CD81 has opposite effects on T and NK cell function, as it enhances receptor-mediated activation inhibits CD16- or IL-12-mediated activation. further investigated this dichotomy found another tetraspanin, CD82, induces same opposing primary cells. Activation by other unrelated stimuli such NKG2D- beta-1 integrin is also...
Acromegaly is characterized by major cardiovascular alterations. Although the underlying mechanisms of these vascular modifications have not been elucidated, recent studies focused on endothelial dysfunction. Nitric oxide (NO) may contribute to increased resistance, reduced platelet aggregation, inhibition smooth muscle cell proliferation, and reduction lipoxygenase activity. At present, no data NO production in acromegalics are available. The aim this study was evaluate effect high levels...
Primary aldosteronism (PA) due to aldosterone-producing adenoma (APA) is the most common curable form of secondary hypertension.In order evaluate blood pressure outcome after adrenalectomy for APA and identify new favorable prognostic factors, data from 42 consecutive patients who underwent were collected 2005 2007.Renin-angiotensin-aldosterone system (upright postsaline infusion test), serum urinary electrolytes, office ambulatory monitoring evaluated at baseline a follow-up 2.7+/-2.2...
A positive correlation between thyroid-stimulating hormone (TSH) and blood pressure (BP) has been identified in normotensives patients with essential hypertension (EH). This study was designed to evaluate, primary aldosteronism (PA) EH, potential association of BP, TSH, ultrasonographic changes the thyroid.We studied 188 patients: 92 PA 96 matched hypertensives. Clinical ambulatory BP (ABP), thyroid function were evaluated all patients. In a subgroup EH (n = 65) ultrasonography performed.In...