A5025200078- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Blood Pressure and Hypertension Studies
- Adrenal Hormones and Disorders
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Electrolyte and hormonal disorders
- Pituitary Gland Disorders and Treatments
- Renin-Angiotensin System Studies
- Sodium Intake and Health
- Ion Transport and Channel Regulation
- Digital Mental Health Interventions
- Glioma Diagnosis and Treatment
- Diabetes Management and Education
- Mobile Health and mHealth Applications
- Vitamin K Research Studies
- Cerebrospinal fluid and hydrocephalus
Princess Alexandra Hospital
2018-2023
The University of Queensland
2018
Erasmus University Rotterdam
2007-2013
Erasmus MC
2007-2012
Aarhus University
2012
Unilateral primary aldosteronism is the most common surgically correctable form of endocrine hypertension and usually differentiated from bilateral forms by adrenal venous sampling (AVS) or computed tomography (CT). Our objective was to compare clinical biochemical postsurgical outcomes patients with unilateral diagnosed CT AVS identify predictors surgical outcomes. Patient data were obtained 18 internationally distributed centers retrospectively analyzed for adrenalectomy management based...
Urinary exosomes are vesicles derived from renal tubular epithelial cells. Exosomes often contain several disease-associated proteins and thus useful targets for identifying biomarkers of disease. Here, we hypothesized that the phosphorylated (active) form sodium chloride cotransporter (pNCC) or prostasin could serve as aldosteronism. We tested this in 2 animal models aldosteronism (aldosterone infusion low-sodium diet) patients with primary were isolated 24-hour urine spot using...
The aim of this study was to investigate the aldosterone–angiotensin (Ang) II interaction in human coronary microarteries (HCMAs). HCMAs, obtained from 75 heart-beating organ donors, were mounted myographs and exposed Ang II, either directly or following a 30-min pre-incubation with aldosterone, 17β-oestradiol, hydrocortisone, p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580, extracellular regulated 1/2 (ERK1/2) PD98059, GPR30 antagonist G15, epidermal growth factor receptor...
The aldosterone-to-renin ratio (ARR) is a widely used screening test for primary aldosteronism. Current guidelines recommend cut-off value of 91 pmol/mU. Studies on its sensitivity, specificity, reproducibility and the role medication have been conflicting. We prospectively assessed characteristics ARR effect combination antihypertensive treatment.In 178 patients with persistent hypertension despite use at least two antihypertensives, plasma renin aldosterone were twice within an interval 4...
To test whether glucocorticoids act as the endogenous agonist of cardiac mineralocorticoid receptors, we evaluated effects aldosterone and corticosterone steroidogenesis vs. steroid uptake from plasma.Both increased left ventricular pressure in rat heart. Aldosterone decreased coronary flow, whereas it. All were blocked by glucocorticoid receptor antagonist, RU486, unaltered canrenoate, or 11beta-hydroxysteroid dehydrogenase (HSD11B)2 inhibitor, carbenoxolone. Unlike blockade, RU486 did not...
Background: Add-on therapy with aldosterone receptor antagonists has been reported to lower blood pressure (BP) in patients uncontrolled hypertension. We assessed potential predictors of this response. Methods: In essential hypertensive BP, despite the use at least two antihypertensives, plasma renin and concentrations transtubular potassium gradient (TTKG) were measured. Patients treated eplerenone 50 mg daily on top their own medication. The office ambulatory BP response biochemical...
Introduction: Transgenic rats expressing the human (pro)renin receptor (h(P)RR) have elevated plasma aldosterone levels despite unaltered levels, in and adrenal, of renin angiotensin II. Materials methods: To investigate whether renin/prorenin–(P)RR interaction underlies these effect on steroidogenesis was compared with that II two (P)RR-expressing adrenocortical cell lines, H295R HAC15. Angiotensin rapidly induced extracellular signal-regulated kinase (ERK) phosphorylation increased...
Background . The long-term efficacy of aldosterone-receptor antagonists (ARAs) as add-on treatment in uncontrolled hypertension has not yet been reported. Methods Data from 123 patients (21 with primary aldosteronism, 102 essential hypertension) difficult-to-treat who received an ARA between May 2005 and September 2009 were analyzed retrospectively for their blood pressure (BP) biochemical response at first followup after start the last follow-up available. Results Systolic BP decreased...
Jansen, P. M.; Verdonk, K.; Imholz, B. P.; Danser, A. H.J.; van den Meiracker, H. Author Information
Jansen, P. M.; Danser, A. H.J.; Van Den Meiracker, H. On behalf of the Dutch Arrat Investigators Author Information
Background: Studies in transgenic rats expressing the human (pro)renin receptor have shown elevated plasma aldosterone levels these animals despite unaffected renin concentration or activity. It has been speculated that this is mediated through a direct effect of on synthesis via ((P)RR). Other studies an increased expression adrenal CYP11B2 mRNA compared to wildtype unchanged angiotensin II (Ang II). We evaluated main steroidogenic enzymes adrenocortical cell line (H295R). Methods: First,...
Aim: To determine what patients with uncontrolled hypertension benefit most from add-on therapy eplerenone. Methods: Essential hypertensives (n=117) blood pressure (BP) despite the use of at least two antihypertensive drugs were treated eplerenone 50 mg on top their own medication. Primary aldosteronism was excluded in all by a salt loading test. BP response and biochemical changes evaluated after 3 months treatment 6 weeks stopped (ES). Potential predictors for change 24-hours ambulatory...
Background: The aldosterone-to-renin ratio (ARR) is a widely used screening test for primary aldosteronism (PA). A commonly adopted cut-off value 91 pmol/mU. However, its sensitivity, specificity, and reproducibility have not been studied extensively. Aim: To characterize the main characteristics of ARR. Design methods: In 179 patients with persistent hypertension despite use at least 2 antihypertensive drugs plasma renin aldosterone were assessed twice an interval to 4 weeks. All underwent...