A5043838550- Rheumatoid Arthritis Research and Therapies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Long-Term Effects of COVID-19
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Systemic Lupus Erythematosus Research
- Lymphoma Diagnosis and Treatment
- Otitis Media and Relapsing Polychondritis
- IgG4-Related and Inflammatory Diseases
- Immunodeficiency and Autoimmune Disorders
- COVID-19 and Mental Health
- Vascular Anomalies and Treatments
- Mycobacterium research and diagnosis
- Peripheral Neuropathies and Disorders
- Monoclonal and Polyclonal Antibodies Research
- Cardiovascular Issues in Pregnancy
- Lymphatic System and Diseases
- Inflammasome and immune disorders
- Hematological disorders and diagnostics
- Spondyloarthritis Studies and Treatments
- Platelet Disorders and Treatments
- Cancer Immunotherapy and Biomarkers
- Pharmacological Effects of Natural Compounds
- Bone and Joint Diseases
- Clostridium difficile and Clostridium perfringens research
- Chronic Obstructive Pulmonary Disease (COPD) Research
ASST Fatebenefratelli Sacco
2025
Sapienza University of Rome
2013-2022
Center for Rheumatology
2021
Policlinico Umberto I
2019
Endothelial dysfunction has been detected in RA patients and seems to be reversed by control of inflammation. Low circulating endothelial progenitor cells (EPCs) have described many conditions associated with increased cardiovascular risk, including RA. The aim this study was investigate the effect inhibition TNF on EPCs patients. Seventeen moderate-severe 12 sex age-matched controls were evaluated. biomarkers tested at baseline after 3 months. identified from peripheral blood mononuclear...
Abstract We aimed to investigate whether small-fibre pathology, a common skin biopsy finding in patients with fibromyalgia, implies clinically important abnormalities of somatosensory system function and verify it is associated voltage-gated sodium channel variants. In 57 consecutively enrolled we used distinguish without pathology. all patients, assessed using quantitative sensory testing (QST) laser-evoked potentials investigated genotyping. then compared these variables found that...
Objective. To assess the adherence to vaccination campaign against SARS-CoV-2 in patients with immunoglobulin-G4-related disease (IgG4-RD) and evaluate development of local systemic adverse events (AEs) following vaccination. Additionally, investigate rate outcome infection IgG4-RD patients. Methods. Patients follow-up before onset pandemic were contacted by telephone asked answer an ad hoc questionnaire regarding their status related AEs The occurrence also recorded. same was proposed...
Rheumatoid Arthritis (RA) is a chronic systemic autoimmune disease. Modifications of gut microbiota seem to be associated with the disease, but impact on therapies' outcome remains unclear. A role T cells in RA pathogenesis has been addressed, particularly Th17/Treg balance. Our study aimed evaluate early (ERA) patients compared control group, fecal composition, short-chain fatty acids concentrations, and levels circulating their own cytokines, before after 3 months standard treatment...
OBJECTIVES: Fibromyalgia (FM) is a common rheumatic disorder characterized by chronic, widespread pain associated with several not painful symptoms. The contribution of gender to the manifestation disease may influence higher prevalence FM among women. In spite this, how patients' influences clinical still well understood. frequent association neuropsychiatric symptoms raised attention on role neurotrophins, including brain-derived neurotrophic factor (BDNF) as potential biomarkers...
Lung involvement is related to the natural history of anti-citrullinated proteins antibodies (ACPA)-positive rheumatoid arthritis (RA), both during pathogenesis disease and as a site disease-related injury. Increasing evidence suggests that there subclinical, early lung course disease, even before onset articular manifestations, which can potentially progress symptomatic interstitial disease. To date, reliable, non-invasive markers subclinical are still lacking in clinical practice. The aim...
<h3>Background</h3> Fibromyalgia (FM) is one of the main causes chronic widespread pain (CWP). It characterized by CWP, which cardinal symptom, and presence more than 11 tender points (hyperalgesia). [1] Other symptoms such as fatigue, sleep disturbances, difficulties with memory concentration, irritable bowel syndrome, headache, depression are frequent. Worldwide mean prevalence FM 2,7% female/male ratio 4:1. In Italy 3,7% same ratio. [2] <h3>Objectives</h3> The aim study to analyze...
<h3>Background</h3> Rheumatoid arthritis (RA) is more prevalent in women than men (F:M=4:1), due to hormonal, genetic and environment factors. Women present higher disease activity markers as Disease Activity Score-28 (DAS28) Health Assessment Questionnaire (HAQ), at the onset after c-DMARDs therapy, without correlation with radiographic damage. <h3>Objectives</h3> The purpose of this study was assess gender differences RA patients anti- tumor necrosis factor (TNF) α treatment....
<h3>Background</h3> In Rheumatoid Arthritis (RA) pathogenesis T helper17 (Th17) and regulatory cells (Treg) are largely represented.<sup>1</sup> Recent studies highlighted the role of intestinal mucosa environment in modulation function. The composition gut microbiota influences Th17/Treg balance host immune response,<sup>2</sup> so exposure to deranged may be crucial RA. <h3>Objectives</h3> aim study was compare Th17 Treg patients with early RA (ERA) a control group (CG) at baseline after...
disease is a protean disease, with various and still not well known manifestations.
<h3>Background</h3> Fibromyalgia (FM) is a chronic widespread pain syndrome associated with symptoms such as sleep disorders, fatigue, depression, anxiety and cognitive alterations severe impairment of the life quality. <h3>Objectives</h3> The aim this study to examine relationship between subjective objective assessment quality analyze predictors fatigue in an Italian cohort FM patients. <h3>Methods</h3> Adult outpatients diagnosed FM, fulfilling both ACR/EULAR 1990 2010 criteria were...
<h3>Background</h3> It is known that citrullinated proteins (ACPA) may be present years before the onset of clinical manifestations Rheumatoid Arthritis (RA). Recent findings suggest lung represent an early site autoimmune-related injury in ACPA-positive patients without signs arthritis (1, 2). <h3>Objectives</h3> The purpose study was to evaluate presence subclinical pulmonary abnormalities subjects and RA-patients through functional inflammatory biomarkers. <h3>Methods</h3> Thirty...
<h3>Background</h3> The ACPA-positive Rheumatoid Arthritis (RA) is a complex disease. Signs of immune activity against citrullinated proteins may be present years before the onset clinical manifestations. Recent findings suggest that lung represent an early site autoimmune-related injury in patients without signs arthritis. <h3>Objectives</h3> purpose study was to evaluate presence subclinical pulmonary abnormalities subjects arthritis and RA-patients through laboratory, functional imaging...
<h3>Background:</h3> Rheumatoid Arthritis (RA) is more prevalent among female individuals. Sex and gender differences may influence disease's progression prognosis. To date, the of physicians' in evaluation RA activity still largely unknown. Objectives: aim study was to investigate a possible discrepancy assessment disease patients evaluated by male physicians. Further compare patient evaluator perceptions about global health status. Methods: we enrolled consecutive patients. Each separately...