A5034700693- Lung Cancer Treatments and Mutations
- Occupational and environmental lung diseases
- Cancer Research and Treatments
- Pleural and Pulmonary Diseases
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Cancer Diagnosis and Treatment
- LGBTQ Health, Identity, and Policy
- Vitamin D Research Studies
- Radiomics and Machine Learning in Medical Imaging
- RNA modifications and cancer
- Renal cell carcinoma treatment
- Lung Cancer Research Studies
- Medical Imaging and Pathology Studies
- Peptidase Inhibition and Analysis
- Hematopoietic Stem Cell Transplantation
- Colorectal Cancer Treatments and Studies
- Lung Cancer Diagnosis and Treatment
- Urticaria and Related Conditions
- COVID-19 Clinical Research Studies
- Neuroblastoma Research and Treatments
- Cancer Treatment and Pharmacology
- Adrenal Hormones and Disorders
- HER2/EGFR in Cancer Research
- Pancreatic and Hepatic Oncology Research
Istituto Superiore di Sanità
2018-2025
Azienda Sanitaria Unità Locale di Reggio Emilia
2018-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2017-2024
Siemens Healthcare (United States)
2024
Azienda Ospedaliera S.Maria
2014-2017
Ospedale Santa Maria
2012-2014
Ospedale Vincenzo Cervello
2002-2010
University of Modena and Reggio Emilia
2007-2010
Università Cattolica del Sacro Cuore
1994
Because endurance exercise causes release of mediators and growth factors active on the bone marrow, we asked whether it might affect circulating hematopoietic progenitor cells (HPCs) in amateur runners [ n = 16, age: 41.8 ± 13.5 (SD) yr, training: 93.8 31.8 km/wk] compared with sedentary controls ( 9, 39.4 10.2 yr). HPCs, plasma cortisol, interleukin (IL)-6, granulocyte colony-stimulating factor (G-CSF), fms-like tyrosine kinase-3 (flt3)-ligand were measured at rest after a marathon (M; 8)...
No AccessJournal of UrologyAdult Urology1 Jan 2015Sunitinib, Pazopanib or Sorafenib for the Treatment Patients with Late Relapsing Metastatic Renal Cell Carcinoma Matteo Santoni, Alessandro Conti, Camillo Porta, Giuseppe Procopio, Cora N. Sternberg, Umberto Basso, Ugo De Giorgi, Sergio Bracarda, Mimma Rizzo, Cinzia Ortega, Francesco Massari, Roberto Iacovelli, Lisa Derosa, Cristina Masini, Michele Milella, Di Lorenzo, Atzori, Maria Pagano, Sebastiano Buti, Rocco Vivo, Alessandra Mosca, Marta...
Estrogens, in particular 17β-estradiol (E2), have a strong influence on the immune system and also affect pathological conditions such as autoimmune diseases. The biological effects of E2 are mediated by two intracellular receptors, i.e., estrogen receptor (ER)α ERβ, which function ligand-activated nuclear transcription factors producing genomic effects. Immune cells express both ERα ERβ that play complex role modulating inflammation. Phytoestrogens display estrogen-like Among them,...
OPINION article Front. Endocrinol., 30 September 2020Sec. Translational Endocrinology Volume 11 - 2020 | https://doi.org/10.3389/fendo.2020.567824
It has been suggested that a positive diagnostic test for human immunodeficiency virus type 1 (HIV-1) during the first 48 h of life is indicative intrauterine transmission, whereas negative tests week with later indicate intrapartum transmission. On basis data from all 140 infected infants in Women and Infants Transmission Study (WITS), probability was estimated an HIV-1 culture would be time at each day if cultures were performed daily. The probabilities (±SE) by days 0, 2, 4, 7, 9, 16, 30...
Study Type – Therapy (case series) Level of Evidence 4 What's known on the subject? and What does study add? Sunitinib sorafenib are orally administered multikinase inhibitors approved for treatment advanced RCC. The limited pharmacokinetics data sunitinib suggest that haemodialysis not significantly alter plasma concentrations. In this retrospective we define safety efficacy tyrosine kinase in patients with metastatic RCC (mRCC) end‐stage renal disease requiring haemodialysis. Even though...
9004 Background. The RAMES Study (EudraCT Number 2016-001132-36) is a multicenter, double-blind, randomized phase II trial exploring the efficacy and safety of addition ramucirumab to gemcitabine as second-line treatment in MPM patients (pts) after platinum/pemetrexed regimens. Methods. pts were assigned (1:1) receive Gemcitabine 1000 mg/m 2 i v on days 1 8 every 21 with Placebo (Arm A) or Ramucirumab 10 mg/kg day 1, 21-day cycle B), until tolerability progressive disease. Pts was stratified...
This study evaluated the loss and expression level of miRNAs 14q32 clusters in acute lymphoblastic leukemia (ALL) patients with cryptic deletions at chromosomal band to investigate their involvement this disease. We demonstrate that a subset ALL cases bearing LOH showed down-regulation miRNA clusters, which is directly linked submicroscopic deletion. As consequence deregulation we reported an inverse correlation target BCL11a, transcription factor involved lymphoid differentiation. These...
Purpose: Malignant pleural mesothelioma (MPM) is an aggressive cancer. Data are not available in prospective trials on correlations between genetic alterations and outcomes of therapies. In this study, we assessed the profile MPM patients (pts) tissue samples. Patients Methods: From December 2016 to July 2018 (end enrolment), 164 pts were enrolled. We evaluated by targeted sequencing mutational a panel 34 genes: ACTB, ACTG1, ACTG2, ACTR1A, BAP1, CDH8, CDK4, CDKN2A, CDKN2B, COL3A1, COL5A2,...
BRAF mutation involved 2-4% of lung adenocarcinoma. Differences in clinicopathologic features and patient outcome exist between V600E non-V600E mutated NSCLC. Thus, we sought to assess the frequency clinical relevance mutations a real-life population advanced-NSCLC, investigating potential prognostic significance distinct genetic alterations.The present multicenter Italian retrospective study advanced mutant Complete data were evaluated for patients.A total 44 BRAFmut NSCLC patients included...
Transgender and gender-diverse (TGD) individuals continue to experience harassment discrimination across various aspects of life, significantly impacting their physical mental health. The scarcity data on general health, particularly regarding dietary habits, remains a challenge in developing effective healthcare strategies for this population. To address gap, we analyzed selected activity (PA), body mass index (BMI) among Italian TGD adults compared the population (IGP). An online anonymous...
Abstract Background Several biomarkers have been identified to predict the outcome of COVID-19 severity, but few data are available regarding sex differences in their predictive role. Aim this study was identify sex-specific severity and progression acute respiratory distress syndrome (ARDS) COVID-19. Methods Plasma levels hormones (testosterone 17β-estradiol), sex-hormone dependent circulating molecules (ACE2 Angiotensin1-7) other known for were measured male female patients at admission...
Hypovitaminosis D is involved in various inflammatory, infectious and autoimmune diseases such as rheumatoid arthritis multiple sclerosis. Moreover, the active form of vitamin D, calcitriol, has been shown to modulate immune response, playing an anti-inflammatory effect. However little known about mechanisms underlying this effect potential sex differences calcitriol regulation. Hence, aim study was investigate whether could act differently modulating T cell immunity age-matched male female...
Identification of epidermal growth factor receptor (EGFR) mutations in lung adenocarcinomas is the single most important predictor clinical response and outcome using EGFR tyrosine kinase inhibitors (TKIs). E746-A750del L858R are common gene alterations, also predicting best to TKIs. We evaluated accuracy mutation-specific antibodies a large cohort adenocarcinomas, with different molecular settings types tissue samples.300 diagnosed on cytology (48 cell blocks), biopsy (157 cases) surgical...