A5020286035- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Melanoma and MAPK Pathways
- RNA Research and Splicing
- Sex and Gender in Healthcare
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Viral Infections and Vectors
- Cutaneous Melanoma Detection and Management
- Leptospirosis research and findings
- Vector-borne infectious diseases
- Computational Drug Discovery Methods
- RNA Interference and Gene Delivery
- Cancer, Lipids, and Metabolism
- Zoonotic diseases and public health
- COVID-19 Impact on Reproduction
- Cancer Immunotherapy and Biomarkers
- COVID-19 Clinical Research Studies
- Bone and Dental Protein Studies
- Gender Roles and Identity Studies
- Long-Term Effects of COVID-19
- Sarcoma Diagnosis and Treatment
- Dendrimers and Hyperbranched Polymers
- interferon and immune responses
Istituto Superiore di Sanità
2015-2025
National Institute of Statistics
2025
Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani
2021
Growing evidence is showing that metastatic cell populations are able to transfer their characteristics less malignant cells. Exosomes (EXOs) membrane vesicles of endocytic origin convey cargo mRNAs, microRNAs (miRs), proteins and lipids from donors proximal as well distant acceptor Our previous results indicated miR-221&222 key factors for melanoma development dissemination. The aim this study was verify whether the tumorigenic properties associated with miR-222 overexpression can be also...
Cutaneous melanoma is the fastest increasing cancer worldwide. Although several molecular abnormalities have been associated with progression, underlying mechanisms are still largely unknown and few targeted therapies under evaluation. Here we show that HOXB7/PBX2 dimer acts as a positive transcriptional regulator of oncogenic microRNA‐221 ‐222. In addition, demonstrating c‐FOS direct target miR‐221&222, identify HOXB7/PBX2→miR‐221&222 →c‐FOS regulatory link, whereby abrogation...
Background/introductionTick-borne encephalitis (TBE) is a severe zoonotic neurological infection caused by the TBE virus (member of Flaviriridae family), and it considered to be one most important tick-borne viral diseases in Europe Asia. In mainland main tick species transmitting Ixodes ricinus. The mostly acquired after bite, but food-borne also possible. notifiable disease EU/EEA since 2012. Despite availability vaccine, its incidence increasing with appearance new foci circulation areas...
Based on clinical and epidemiological investigations conducted so far, gender disparity exists in outcomes regarding Coronavirus disease 2019 (COVID-19) affected patients as men show more serious forms higher lethality than women.1 At present, mechanisms underlying the observed difference are not clear enough. The SARS-CoV-2 virus, responsible for COVID-19, belongs to family has high similarity with virus causing SARS-CoV MERS. Hence, thanks knowledge derived from previous studies performed...
A proper balance between saturated and unsaturated fatty acids (FAs) is required for maintaining cell homeostasis. The increased demand of FAs to assemble the plasma membranes continuously dividing cancer cells might unbalance this ratio critically affect tumour outgrowth. We unveiled role stearoyl-CoA desaturase SCD5 in converting into mono-unsaturated during melanoma progression. down-regulated advanced its restored expression significantly reduced malignancy, both vitro vivo, through a...
Abstract Long non-coding RNAs are emerging as new molecular players involved in many biological processes, such proliferation, apoptosis, cell cycle, migration, and differentiation. Their aberrant expression has been reported variety of diseases. The aim this study is the identification functional characterization clinically relevant lncRNAs responsible for inhibition miR-145-5p, a key tumor suppressor thymic epithelial tumors (TETs). Starting from gene analysis by microarray cohort fresh...
Background Tick-borne encephalitis (TBE) is a disease which can lead to severe neurological symptoms, caused by the TBE virus (TBEV). The natural transmission cycle occurs in foci and involves ticks as vectors several key hosts that act reservoirs amplifiers of infection spread. Recently, incidence Europe has been rising both endemic new regions. Aim In this study we want provide comprehensive understanding main ecological environmental factors affect spread across Europe. Methods We...
Gender differences in caregiving may determine social and/or health inequalities among family caregivers (FCs). This study aimed to analyse gender specific of burden and quality life (QoL) FCs belonging ten different rare diseases (RD).Burden levels QoL data, derived from a sample 210 RD patients, were analysed by student t-test, Anova Kruskal-Wallis followed multiple comparisons evaluation factors, including sex, correlation regression analyses.FCs caring for Prader Willi, X-fragile,...
Accumulating evidences have shown the association between aberrantly expressed microRNAs (miRs) and cancer, where these small regulatory RNAs appear to dictate cell fate by regulating all main biological processes. We demonstrated responsibility of circuitry connecting oncomiR-221&222 with tumor suppressors miR-126&126* in melanoma development progression. According inverse correlation endogenous miR-221&222 miR-126&126*, respectively increasing or decreasing malignancy, their enforced...
// Rossella Puglisi 1, * , Maria Bellenghi Giada Pontecorvi 1 Alessandro Gulino 3 Marina Petrini Federica Felicetti 2 Lisabianca Bottero Gianfranco Mattia # and Alessandra Carè Center for Gender-Specific Medicine, Oncology Unit-Istituto Superiore di Sanita', Rome, Italy Department of Molecular Istituto Health Science, Tumor Immunology Unit, Human Pathology Section, Palermo University School Palermo, These authors contributed equally to this work shared seniorship Correspondence to: Mattia,...
Abstract Background Several biomarkers have been identified to predict the outcome of COVID-19 severity, but few data are available regarding sex differences in their predictive role. Aim this study was identify sex-specific severity and progression acute respiratory distress syndrome (ARDS) COVID-19. Methods Plasma levels hormones (testosterone 17β-estradiol), sex-hormone dependent circulating molecules (ACE2 Angiotensin1-7) other known for were measured male female patients at admission...