A5026982095- Acute Ischemic Stroke Management
- Multiple Sclerosis Research Studies
- Migraine and Headache Studies
- Cerebrovascular and Carotid Artery Diseases
- Stroke Rehabilitation and Recovery
- Neurological Disorders and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
- Polyomavirus and related diseases
- Neurological Disease Mechanisms and Treatments
- Trigeminal Neuralgia and Treatments
- Cerebral Venous Sinus Thrombosis
- Cardiovascular Syncope and Autonomic Disorders
- Cerebrovascular and genetic disorders
- Dementia and Cognitive Impairment Research
- Advanced MRI Techniques and Applications
- Vestibular and auditory disorders
- Sympathectomy and Hyperhidrosis Treatments
- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Ophthalmology and Eye Disorders
- Psychosomatic Disorders and Their Treatments
- Neurosurgical Procedures and Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- Transcranial Magnetic Stimulation Studies
- Long-Term Effects of COVID-19
Sapienza University of Rome
2013-2025
Institute of Neurological Sciences
2001-2008
University Hospital of Lausanne
1997-2000
Institute of Social and Preventive Medicine
2000
Neurology, Inc
1999
To determine whether TIAs have a neuroprotective effect.Ischemic tolerance or preconditioning, which protects the brain against stroke, has been demonstrated in animal models of cerebral ischemia. Because TIA may represent clinical model ischemic tolerance, patients with before infarction (CI) therefore better outcome than without CI.A total 2,490 admitted consecutively to primary care center for first-ever CI anterior circulation were divided into two groups on basis presence absence prior...
<i>Background:</i> An impairment of cerebral microvessels is reported both in normal ageing and senescence-associated processes, as well Alzheimer’s disease (AD) vascular dementia (VaD). The aim this study was to explore hemodynamics by transcranial Doppler VaD AD, compared with age-matched control subjects. <i>Methods:</i> Transcranial investigated all patients the basal condition. Cerebral vasoreactivity hyper- hypocapnia evaluated CO<sub>2</sub> mixture...
Adventitial vasa vasorum and plaque vascularization have been established as predictors of unstable atheromasic lesions in cerebro- cardiovascular patients. Ultrasound contrast agents provide reliable information on tissue perfusion microcirculation. We used ultrasound duplex scanning to identify carotid vascularization.Contrast was performed 23 patients with plaques different degree stenosis echogenicity.Plaque detected the fibrous fibro-fatty not observed calcific nor necrotic hemorrhagic...
Background and purpose: Post‐stroke depression (PSD) is one of the most frequent complications stroke, with a prevalence ranging 20–60%. As PSD seems to be related stroke severity, we hypothesized that would lower in patients minor stroke. Methods: We investigated predictors over 30‐month follow‐up period cohort ischaemic (NIHSS ≤ 5). Results: enrolled 105 (mean age 64.38 ± 11.2 years, M/F 69/36). was diagnosed 43 (41%) patients, 40 (93%) whom had dysthymia; 22% were already depressed at 1...
Ocrelizumab is an anti-CD20 monoclonal antibody for the treatment of multiple sclerosis (MS) that closely related to rituximab. We describe a case hepatitis B virus (HBV) reactivation in MS patient with resolved HBV infection receiving ocrelizumab. was monitored HBV-DNA and surface antigen periodic assessment. Anti-HBV entecavir started after detection. can reactivate viral replication patients infection. monitoring seems effective safe option management these patients. More studies are...
To assess patients who have had a stroke for the subsequent development of poststroke dementia (PSD) and to determine if characteristics delayed PSD (dPSD) vary in long-term follow-up.Nondemented were followed from 6 months after onset 4 years. Dementia was diagnosed by International Classification Diseases-10 criteria; etiology National Institute Neurological Communication Disorders Stroke/Alzheimer's Disease Related Association Neurologic Stroke/Association Internationale pour la Recherche...
Abstract Objective To investigate the characteristics and nature of headache in a population patients with acromegaly. Background Headache is frequently described by pituitary adenomas. Although it mainly considered secondary disorder, can persist despite effective therapy for disease. A proper description according to subtype adenoma not available literature. In this light, we aimed analyze Methods registry‐based retrospective cohort study, features were collected through structured...
Background The prevalence of cranial nerve involvement in Multiple Sclerosis (MS) varies across studies. It has been speculated that first presentation disease with – except for optic neuritis may be associated milder progression. Aim This study compares the clinical outcome patients MS a 4-year follow-up initial symptoms (ON) versus those other (OCN) involvement. Materials and methods Retrospective analysis patient database tertiary referral university center. We included treatment-naïve...
In the early stage of stroke, occurrence neurologic and medical complications is associated with clinical deterioration. Previous studies were focused on first week after stroke onset. The aim this study was to evaluate impact outcome in patients subacute stage.We prospectively evaluated influence feasible (MC) not for monitoring (NMC) all admitted consecutively our unit. Patients divided into three classes according severity by National Institutes Health Stroke Scale score. A change score...
Chronic cerebrospinal venous insufficiency (CCSVI) has recently been reported to be associated with multiple sclerosis (MS). However, its actual prevalence, possible association specific MS phenotypes, and potential pathophysiological role are debated. We analysed the clinical data of 710 patients attending six centres (five Italian one Canadian). All were submitted Doppler sonography diagnosed as having or not CCSVI according criteria Zamboni et al. Overall, was in 86% patients, but...
Therapeutic management of Chronic Migraine (CM), often associated with Medication Overuse Headache (MOH), is chiefly empirical, as no biomarker predicting or correlating clinical efficacy available to address therapeutic choices. The present study searched for neurophysiological correlates Greater Occipital Nerve Block (GON-B) effects in CM. We recruited 17 CM women, whom 12 MOH, and 19 healthy volunteers (HV). Patients had preventive treatment since at least 3 months. After a 30-day...
Repetitive focal muscle vibration (rMV) is known to promote neural plasticity and long-lasting motor recovery in chronic stroke patients. Those structural functional changes within the network underlying occur very first hours after stroke. Nonetheless, our knowledge, no rMV-based studies have been carried out acute patients so far, clinical benefit of rMV this phase yet be determined. The aim randomized double-blind sham-controlled study investigate short-term effect on Out 22 patients, 10...
We studied the effects of short-term psychodynamic psychotherapy (STPP) and pharmacological therapy in 26 consecutive patients with probable medication overuse headache (pMOH). Patients underwent a standard in-patient detoxification protocol, lasting mean 7 days. Eleven overused non-steroidal anti-inflammatory drugs (NSAIDs), five combination NSAIDs triptans, four NSAIDs, three triptans ergot derivates. Preventive was initiated during detoxification. The STPP protocol comprised Brief...
Chronic olfactory dysfunction after SARS-CoV-2 infection occurs in approximately 10% of patients with COVID-19-induced anosmia, and it is a growing public health concern. A regimen training anti-neuroinflammatory therapy co-ultramicronized palmitoylethanolamide luteolin (um-PEA-LUT) has shown promising results clinical trials; however, 15% treated do not achieve full recovery normal threshold, almost 5% have no recovery. Disease-modifying therapies (DMTs), which are used to treat autoimmune...
Objectives Common carotid artery (CCA) intima-media thickness (IMT) is considered an atherosclerosis risk marker. Thickening of the complex accelerated by vascular factors, in particular, age and elevated blood pressure. Nonetheless, it also reflects intimal hyperplasia fibrocellular hypertrophy provoked nonatherosclerotic mechanisms such as tensile wall stress. The aims our study were to investigate relationship between CCA IMT presence factors correlate with degree distal internal (ICA)...
Abstract Background During severe immunosuppression or treatment with specific biological drugs, human polyomavirus JC (JCPyV) may establish a lytic infection in oligodendrocytes, leading to progressive multifocal leukoencephalopathy (PML). Beyond AIDS, which represents the most common predisposing condition, several drugs have been associated development of PML, such as natalizumab, fingolimod and dimethyl fumarate, showed increase risk PML multiple sclerosis (MS) population. JCPyV...
Neuroinflammation is believed to be involved in the pathophysiological mechanisms of silent brain infarcts (SBI). However, immunological profile SBI has been scarcely investigated. In context a national research project named SILENCE, aimed at investigating clinical, biochemical and pathogenic features SBI, we have measured plasma some inflammatory-related molecules patients (n = 21), with recent lacunar (LI, n 28) healthy controls 31), consecutively enrolled four Italian centres. A panel...