A5064045654- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Epilepsy research and treatment
- Acute Ischemic Stroke Management
- Peripheral Artery Disease Management
- Migraine and Headache Studies
- Long-Term Effects of COVID-19
- Neurological and metabolic disorders
- Botulinum Toxin and Related Neurological Disorders
- Autoimmune Neurological Disorders and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Vascular Procedures and Complications
- Pharmacological Effects and Toxicity Studies
- Infectious Encephalopathies and Encephalitis
- Neurological diseases and metabolism
- Cerebrovascular and Carotid Artery Diseases
- Mesenchymal stem cell research
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Central Venous Catheters and Hemodialysis
- Glycogen Storage Diseases and Myoclonus
- Psychosomatic Disorders and Their Treatments
- RNA regulation and disease
- Alcoholism and Thiamine Deficiency
- Genetic Neurodegenerative Diseases
Shree Krishna Hospital
2015-2025
Bhaikaka University
2021-2025
Pramukhswami Medical College
2016-2025
M.S. Ramaiah Medical College
2014-2024
Ochsner Medical Center
2015-2024
M S Ramaiah Memorial Hospital
2013-2024
Government Medical College
2023
Deenanath Mangeshkar Hospital and Research Center
2022-2023
Aster Medcity
2023
Ruby Hall Clinic
2023
Peripheral vascular disease of the lower extremities comprises a clinical spectrum that extends from no symptoms to presentation with critical limb ischemia (CLI). Bone marrow derived Mesenchymal Stem Cells (BM- MSCs) may ameliorate consequences CLI due their combinatorial potential for inducing angiogenesis and immunomodulatory environment in situ. The primary objective was determine safety BM- MSCs patients CLI. Prospective, double blind randomized placebo controlled multi-center study...
Abstract Critical limb ischemia (CLI) due to Buerger's disease is a major unmet medical need with high incidence of morbidity. This phase II, prospective, nonrandomized, open-label, multicentric, dose-ranging study was conducted assess the efficacy and safety i.m. injection adult human bone marrow-derived, cultured, pooled, allogeneic mesenchymal stromal cells (BMMSC) in CLI disease. Patients were allocated three groups: 1 2 million cells/kg body weight (36 patients each) standard care (SOC)...
Abstract The benefits of large-scale genetic studies for healthcare the populations studied are well documented, but these have traditionally ignored people from some parts world, such as South Asia. Here we describe whole genome sequence (WGS) data 4806 individuals recruited delivery systems Pakistan, India and Bangladesh, combined with WGS 927 isolated Asian populations. We characterize population structure in Asia a genotyping array (SARGAM) imputation reference panel that optimized...
A middle-aged man presented with imbalance and involuntary jerky movements of the body 3 weeks after initial recovery from coronavirus disease 2019 (COVID-19) lung infection, diagnosed by positive high-resolution CT thorax (COVID Reporting Data System 5) reverse transcription PCR (RT-PCR) nasal swab.He had opsoclonus, cortical myoclonus, symmetric cerebellar ataxia speech, limbs, trunk, gait on examination 1 (video 1).His MRI brain contrast, CSF examination, HIV, Venereal Disease Research...
Stroke results in significant caregiver burden and strain.The main objectives of this study is to assess the its consequences caregivers stroke patients determine associated factors caregivers' burden.A cross-sectional was conducted over 1 year on 70 consecutive who attended Shree Krishna Hospital, Karamsad clinic. Demographic clinical characteristics all were recorded after obtaining consent. The modified rankin scale Barthel index administered patient, whereas Caregiver strain index,...
Neurological symptoms are common manifestation in acute COVID-19. This includes hyper- and hypokinetic movement disorders. Data on their outcome, however, is limited.Cases with new-onset COVID-19-associated disorders were identified by searching the literature. Authors contacted for outcome data which reviewed analyzed.Movement began 12.6 days average after initial onset of 92% patients required hospital admission (mean duration 23 days). In a fraction (6 27; 22%; 4 males/2 females, mean age...
Importance Preclinical and phase 1/2 studies with esmolol hydrochloride suggest its potential role in treatment of diabetic foot ulcers (DFUs). Objective To study the efficacy topical for healing uninfected DFUs. Design, Setting, Participants A randomized, double-blind, multicenter, 3 clinical trial was conducted from December 26, 2018, to August 19, 2020, at 27 referral centers across India. included adults Interventions were randomized after a run-in (1 week) receive esmolol, 14%, gel...
Abstract Background Recent studies have advanced our understanding of the genetic drivers Parkinson's disease (PD). Rare variants in more than 20 genes are considered causal for PD, and latest PD genome‐wide association study (GWAS) identified 90 independent risk loci. However, there remains a gap genetics outside European populations which vast majority these were focused. Objective The aim was to identify factors South Asian population. Methods A total 674 subjects predominantly with age...
Over the past two decades, our understanding of Parkinson's disease (PD) has been gleaned from discoveries made in familial and/or sporadic forms PD Caucasian population. The transferability and clinical utility genetic to other ethnically diverse populations are unknown. Indian population under-represented research. Genetic Architecture India (GAP-India) project aims develop one largest clinical/genomic bio-bank for India. Specifically, GAP-India to: (1) a pan-Indian deeply phenotyped...
Objectives Migraine, a prevalent neurological disorder, remains under-recognized and stigmatized, potentially impeding optimal management. This study aimed to quantify migraine-related stigma its associations in rural Indian setting, addressing critical knowledge gap low-resource contexts. Primary objectives: was assess the prevalence patterns of perceived among migraine patients neurology clinic. Secondary examine relationship between levels headache impact severity identify...
Abstract The genomic landscape of the Indian population, particularly for age-related disorders like Parkinson’s disease (PD) remains underrepresented in global research. Genetic variability PD has been studied predominantly European populations, offering limited insights into its role within population. To address this gap, we conducted first pan-India survey involving 4,806 cases and 6,364 controls, complemented by a meta-analysis integrating summary statistics from multi-ancestry...
Abstract Anti-IgLON5 disease is an evolving entity that lies at the confluence of autoimmunity and neurodegeneration. Reports from India remain sparse. In this series, we describe seven Indian patients with anti-IgLON5–related disease. Patients presented across fifth to eighth decades a mean duration illness 16 months. All had movement disorders, which included gait ataxia, parkinsonism, chorea. Six sleep disturbances. Five frontal dysexecutive dementia phenotype. Two epilepsy. Bulbar...
Abstract Objective We aimed to evaluate and compare the effectiveness of physical yoga therapies as an adjuvant therapy along with standard pharmacologic treatment in patients migraine. Materials Methods A total 61 consenting diagnosed have migraine were randomized into three groups receive either alone, treatment, or treatment. The respective intervention was taught group they advised perform it daily for 3 months weekly telephonic reminders review their activity logs. Outcome measures...
<b><i>Introduction:</i></b> In India, there have been only few published studies of Parkinson’s disease (PD) showing a wide range prevalence. We conducted this study to determine the prevalence PD in rural population Gujarat, western region India. <b><i>Methods:</i></b> This cross-sectional descriptive was villages Anand, district between September 2019 and February 2020. used multistep approach including screening questionnaire video recording...
Purpose: Manual interpretation of chest radiographs is a challenging task and prone to errors. An automated system capable categorizing based on the pathologies identified could aid in timely efficient diagnosis pathologies. Method: For this retrospective study, 4476 were collected between January April 2021 from two tertiary care hospitals. Three expert radiologists established ground truth, all analyzed using deep-learning AI model detect suspicious ROIs lungs, pleura, cardiac regions....