A5021664158- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Cerebral Venous Sinus Thrombosis
- RNA regulation and disease
- Glycogen Storage Diseases and Myoclonus
- Stroke Rehabilitation and Recovery
- Neurological diseases and metabolism
- Acute Ischemic Stroke Management
- Lung Cancer Treatments and Mutations
- Radiopharmaceutical Chemistry and Applications
- Intensive Care Unit Cognitive Disorders
- RNA and protein synthesis mechanisms
- Schizophrenia research and treatment
- Cardiovascular Disease and Adiposity
- Porphyrin Metabolism and Disorders
- Autoimmune Neurological Disorders and Treatments
- Restless Legs Syndrome Research
- Peripheral Artery Disease Management
- Metabolism and Genetic Disorders
- Long-Term Effects of COVID-19
- Hearing Loss and Rehabilitation
- CRISPR and Genetic Engineering
- Epilepsy research and treatment
- Radiation Dose and Imaging
- Brain Metastases and Treatment
Mazumdar Shaw Medical Centre
2022-2025
Narayana Health
2020-2024
Sree Chitra Thirunal Institute for Medical Sciences and Technology
2018-2022
Abstract Background ADCY5 ‐related dyskinesia is characterized by early‐onset movement disorders. There currently no validated treatment, but anecdotal clinical reports and biological hypotheses suggest efficacy of caffeine. Objective The aim to obtain further insight into the safety caffeine in patients with dyskinesia. Methods A retrospective study was conducted worldwide 30 a proven mutation who had tried or were taking for Disease characteristics treatment responses assessed through...
Over the past two decades, our understanding of Parkinson's disease (PD) has been gleaned from discoveries made in familial and/or sporadic forms PD Caucasian population. The transferability and clinical utility genetic to other ethnically diverse populations are unknown. Indian population under-represented research. Genetic Architecture India (GAP-India) project aims develop one largest clinical/genomic bio-bank for India. Specifically, GAP-India to: (1) a pan-Indian deeply phenotyped...
Abstract The genomic landscape of the Indian population, particularly for age-related disorders like Parkinson’s disease (PD) remains underrepresented in global research. Genetic variability PD has been studied predominantly European populations, offering limited insights into its role within population. To address this gap, we conducted first pan-India survey involving 4,806 cases and 6,364 controls, complemented by a meta-analysis integrating summary statistics from multi-ancestry...
Recent reports of hearing impairment in Parkinson's disease (PD) have suggested that auditory dysfunction could be a non-motor manifestation PD. These were based on observations elderly patients for whom presbycusis may, to some extent, contributed dysfunction. Therefore, we aimed explore the functions younger with PD.We conducted case-control study relatively (< 55 years age at time) population PD and healthy volunteers test whether is significant Pure tone audiometry (PTA) brainstem evoked...
Neurological manifestations of coronavirus disease (COVID-19) have increasingly been reported since the onset pandemic. Herein, we report a relatively new presentation. A patient in convalescence period following febrile illness with lower respiratory tract infection (fever, myalgia, nonproductive cough) presented generalized disabling myoclonus, which is phenotypically suggestive brainstem origin, along additional truncal cerebellar ataxia. His neurology work-ups, such as brain MRI,...
Background: Cerebral venous sinus thrombosis (CVST) is a rare, treatable cause of stroke. Even though CVST has an established medical treatment, 15% patients remain refractory to treatment. These may be candidates for endovascular treatment (EVT), yet the selection remains challenge. The study aims understand profile and outcome treated with EVT type procedure associated good outcomes. Methods: This single-center, retrospective analysis who underwent from 2009 till 2022. Patients received...
Background: Large core acute ischemic strokes have predominantly been excluded from endovascular therapy (EVT) studies due to perceived higher risks of hemorrhage and poorer functional outcomes. However, recent randomized controlled trials (RCTs) indicate that EVT for large vessel occlusion (LVO) improves outcomes compared medical management alone, despite hemorrhagic transformation rates, with no corresponding increase in symptomatic intracerebral (sICH) rates. The real-world this...
Calcific miliary brain metastasis is an extremely rare form of secondaries. A 52-year-old man diagnosed with lung adenocarcinoma, on oncotherapy gefitinib had a partial initial response to treatment. Later he was readmitted seizures and cognitive dysfunction. His computed tomography (CT) magnetic resonance imaging (MRI) were normal. However, his later CT images revealed multiple small calcified lesions over both hemispheres contrast MRI scattered tiny nodules enhanced by gadolinium bilateral...
New-onset apraxia of lid opening (ALO) is reported to occur in Parkinson's disease (PD) patients following Deep Brain Stimulation (DBS). There are only few systematic studies on this uncommon disorder eyelid movements.We aimed examine the frequency, temporal evolution, predisposing factors and response treatment, new-onset ALO PD who underwent bilateral subthalamic nucleus (STN) DBS.We retrospectively reviewed data STN DBS at our centre between 1999 2017, with a minimum 2 years follow up...
Abstract Progressive supranuclear palsy (PSP) has emerged as a key area of interest among researchers worldwide, including those in India, who have actively studied the disorder over past several decades. This review meticulously explores extensive range Indian research on PSP up to present and offers insights into both current initiatives potential future directions for managing within region. Historical contributions spanned 80 publications from 1974 2023, encompassing diverse themes...
Sir, PLA2G6-associated neurodegeneration (PLAN) is a subtype of Neurodegeneration with Brain Iron Accumulation (NBIA), caused by mutations in the PLA2G6 gene on chromosome 22q13.1. It traditionally manifests as three distinct phenotypes linked to age onset: infantile neuroaxonal dystrophy (INAD), atypical dystrophies (ANAD), and PLA2G6-related dystonia–parkinsonism (PLAN-DP).[1,2] We report an Indian case childhood onset features suggestive overlap PLAN. A 21-year-old boy presented history...
BACKGROUND: Pranayama is an art of controlling the life force breath.It produces many systemic psycho-physical effects in body, besides its specific on respiratory functions.It claimed that practice 'pranayama' one ways to achieve this goal physical and mental health.'Regular pranayama has found be helpful developing a healthy body sound mind.Several studies have shown beneficial parameters patients with disorders, especially asthmatics.The present study was done find out whether short-term...
Abstract Aripiprazole, a novel neuroleptic and dopamine system stabilizer, is hailed as 3 rd generation by some claimed to have partial agonistic activity at D2 receptors (D2R), distinguishing it from other antipsychotics-D2 receptor antagonists. Many studies extensively described extrapyramidal syndrome (EPS) profiles of earlier atypical neuroleptics including clozapine, quetiapine, olanzapine, ziprasidone, risperidone. Despite the D2R mechanism, EPS due aripiprazole sporadically reported –...
Background Numerous studies have shown that yoga can aid patients with Parkinson’s disease (PD) in managing their motor function, functional mobility, balance, anxiety, and overall quality of life. However, most the reported research either needed more power or evaluated results during after intervention. Due to long-standing nature PD, there are still few longitudinal investigating potential decrease progression disease. Purpose We study whether sustained adjunct intervention slows PD...