A5032207709- Long-Term Effects of COVID-19
- Epilepsy research and treatment
- COVID-19 Clinical Research Studies
- Mosquito-borne diseases and control
- Peripheral Neuropathies and Disorders
- Neuroscience and Neuropharmacology Research
- Infectious Encephalopathies and Encephalitis
- Hearing Loss and Rehabilitation
- Fetal and Pediatric Neurological Disorders
- Glioma Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Lattice Boltzmann Simulation Studies
- Cardiovascular Health and Disease Prevention
- Multisensory perception and integration
- Neuroscience and Music Perception
- Hereditary Neurological Disorders
- Pharmacological Effects and Toxicity Studies
- CNS Lymphoma Diagnosis and Treatment
- Ethics in Clinical Research
- HIV-related health complications and treatments
- Viral-associated cancers and disorders
- Bacterial Infections and Vaccines
- Autoimmune Neurological Disorders and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Sympathectomy and Hyperhidrosis Treatments
National Hospital for Neurology and Neurosurgery
2015-2024
University College London
2015-2024
University College London Hospitals NHS Foundation Trust
2020-2024
Narayana Health
2024
Philadelphia University
2024
University of Pennsylvania
2024
North Kent College
2022
Transnational Press London
2022
Royal London Hospital
2020
UCL Australia
2012
Abstract Preliminary clinical data indicate that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with neurological and neuropsychiatric illness. Responding to this, a weekly virtual disease 19 (COVID-19) neurology multi-disciplinary meeting was established at the National Hospital, Queen Square, in early March 2020 order discuss begin understand presentations patients suspected COVID-19-related disorders. Detailed paraclinical were collected from cases...
Increasing age is the biggest risk factor for dementia, of which Alzheimer’s disease commonest cause. The pathological changes underpinning are thought to develop at least a decade prior onset symptoms. Molecular positron emission tomography and multi-modal magnetic resonance imaging allow key processes cognitive impairment – including β-amyloid depostion, vascular disease, network breakdown atrophy be assessed repeatedly non-invasively. This enables potential determinants dementia...
•One of the largest UK centres, experience neuroimaging in patients with COVID-19.•Most common finding was microhaemorrhage, a predilection for corpus callosum.•Followed by stroke, white matter hyperintensities, hypoxic-ischaemic changes.•Other findings were acute haemorrhagic necrotising encephalopathy and ADEM-like changes.•Prolonged hypoxaemia, consumption coagulopathy endothelial disruption reflect likely pathogenesis. AIMTo describe neuroradiological changes coronavirus disease 2019...
We present a validation study comparing results from patient-specific lattice-Boltzmann simulation to transcranial Doppler (TCD) velocity measurements in four different planes of the middle cerebral artery (MCA). As part study, we compared simulations using Newtonian and Carreau-Yasuda rheology model. also investigated viability downscaled velocities reduce required resolution. Simulations with unscaled predict maximum flow an error less than 9%, independent model chosen. The accuracy...
White matter (WM) abnormalities are frequently seen on brain MRI of HIV positive (HIV+) patients. We aimed to determine the prevalence unexplained WM and their associations with disease cardiovascular risk factors. conducted a retrospective, cross-sectional study HIV+ patients between 2004 2009 at our center. Clinical laboratory data were compiled, images independently reviewed for lesions. Images obtained from 254 patients: 70% male, 53% white, 40% black, mean age 42 years, median current...
Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, skin changes (POEMS) syndrome is a rare multisystem disease associated with plasma-cell dyscrasia. Although pachymeningeal involvement has occasionally been described, MRI of the central nervous system (CNS) not yet extensively investigated.We retrospectively evaluated CNS in Europe's largest single-center cohort POEMS syndrome. Of 77 patients who have formally diagnosed POEMS, 41 had brain and 29 spine. A control group 33...
Objective To summarise the incidental findings detected on brain imaging and blood tests during first wave of data collection for Insight 46 study. Design Prospective observational sub-study a birth cohort. Setting Single-day assessment at research centre in London, UK. Participants 502 individuals were recruited from MRC National Survey Health Development (NSHD), 1946 British cohort, based pre-specified eligibility criteria; mean age was 70.7 (SD: 0.7) 49% female. Outcome measures Data...
Abstract Objective To find the covert patterns of abnormality in patients with unilateral temporal lobe epilepsy (TLE) and visually normal brain magnetic resonance images (MRI‐negative), comparing them to those visible abnormalities (MRI‐positive). Methods We used multimodal MRI from TLE employed contemporary machine learning methods predict known laterality seizure onset 104 subjects (82 MRI‐positive, 22 MRI‐negative). A visualization approach entitled "Importance Maps" was developed...
This study reports on a novel brain pathology in young patients with frontal lobe epilepsy (FLE) that is distinct from focal cortical dysplasia (FCD).Surgical specimens 20 adults FLE (mean age, 30 years) were investigated histological/immunohistochemical markers for laminar architecture, mammalian target of (mTOR) pathway activation and inhibition, cellular autophagy, synaptic vesicle-mediated trafficking as well proteomics analysis. Findings correlated pre-/postoperative clinical, imaging,...
Cerebrovascular diseases such as brain aneurysms are a primary cause of adult disability. The flow dynamics in arteries, both during periods rest and increased activity, known to be major factor the risk aneurysm formation rupture. precise relation is however still an open field investigation. We present automated ensemble simulation method for modelling cerebrovascular blood under range regimes. By automatically constructing performing multiscale simulations, where we unidirectionally...
ABSTRACT We have been investigating epigenetic alterations in the brain during human aging and Alzheimer’s disease (AD), evidence for histone acetylation both protecting epigenome driving AD. Here we extend our studies to chromatin architecture via looping studies, with binding of key proteins required looping: CTCF RAD21. detected changes RAD21 levels localization, finding major AD compared fewer healthy aging. In study 3D genome conformation changes, identified stable topological...
<h3>Objective</h3> To assess the prevalence of brain MRI abnormalities in people with epilepsy rural China and to compare it that individuals United Kingdom. <h3>Methods</h3> Brain scans were obtained who participated a community-based program between July 2010 December 2012. Individual epileptogenic lesion types reviewed their associations seizure control examined. The findings compared 2 previous similar studies <h3>Results</h3> Among 597 (58% male, median age 38 years) analyzed, 488 (82%)...
It is recognized that IDH mutation negative, low-grade epilepsy associated tumors (LEAT) can show diffuse growth patterns and lack the diagnostic hallmarks of either classical dysembryoplastic neuroepithelial (DNT) or typical ganglioglioma. "Nonspecific DNT" more recently "polymorphous tumor young" have been terms used for these entities. There are few reports on MRI recognition glioneuronal (dGNT), which important in planning extent surgical resection. In 27 LEATs T1, T2, FLAIR,...
The International League against Epilepsy (ILAE) updated the classifications of seizures and epilepsies in 2017. 2017 were compared with 1980s rural China.People epilepsy receiving treatment under National Control Programme recruited from areas China. Their epileptic syndrome classified using ILAE classification system then re-classified according to system. Differences seizure, aetiology identified.A total 597 individuals (58% males, aged 6-78 years) included. Amongst them 535 (90%) had a...
Balendra, Rubika MRCP, PhD; North, Matthew Kumar, Guru MBBS, MRCP; Qutab, Saad Raouf, Hamid Aminy Delamont, Shane S. FRACP, FRCP(Lond), MD; Chong, M. MD, FRCP; Hamdulay, Shahir PhD, Rahman, Mushtaqur Robertson, Fergus J. FRCR; Hoskote, Chandrashekar Bremner, Fion D. FRCOphth; Farmer, Simon F. Watkins, Laurence FRCS(SN); Zandi, Michael Manji, Hadi Trip, Anand Paterson, Ross W. Swayne, Orlando B. C. PhDEditor(s): Avery, Robert DO; Golnik, Karl Froment, Caroline Wang, An-Guor MD Author Information
Sir, PLA2G6-associated neurodegeneration (PLAN) is a subtype of Neurodegeneration with Brain Iron Accumulation (NBIA), caused by mutations in the PLA2G6 gene on chromosome 22q13.1. It traditionally manifests as three distinct phenotypes linked to age onset: infantile neuroaxonal dystrophy (INAD), atypical dystrophies (ANAD), and PLA2G6-related dystonia–parkinsonism (PLAN-DP).[1,2] We report an Indian case childhood onset features suggestive overlap PLAN. A 21-year-old boy presented history...