A5037746317- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Botulinum Toxin and Related Neurological Disorders
- Mitochondrial Function and Pathology
- Neurological diseases and metabolism
- Transcranial Magnetic Stimulation Studies
- Genetics and Neurodevelopmental Disorders
- Neurological and metabolic disorders
- Restless Legs Syndrome Research
- RNA regulation and disease
- Hereditary Neurological Disorders
- Metabolism and Genetic Disorders
- Glycogen Storage Diseases and Myoclonus
- Genomics and Rare Diseases
- Autoimmune Neurological Disorders and Treatments
- Epilepsy research and treatment
- Sleep and Wakefulness Research
- Autism Spectrum Disorder Research
- Psychosomatic Disorders and Their Treatments
- Trace Elements in Health
- Trigeminal Neuralgia and Treatments
- Balance, Gait, and Falls Prevention
- Alzheimer's disease research and treatments
- Nuclear Receptors and Signaling
National Institute of Mental Health and Neurosciences
2016-2025
Deleted Institution
2021-2023
Institute of Mental Health and Neurosciences
2023
Creative Commons
2023
John Wiley & Sons (United States)
2021-2023
Government Medical College
2021
Montreal Neurological Institute and Hospital
2018
Novartis (Canada)
2018
Maulana Azad Medical College
2012
ABSTRACT: Background: Early-onset Parkinson’s disease (EOPD) refers to patients with (PD) whose age at onset is less than 50 years. Literature on the non-motor symptoms (NMS) in these very limited Indian context. We aimed study NMS EOPD and its impact quality of life (QoL). Methods: included 124 a mean between 21 45 years 60 healthy controls (HC). were assessed using validated scales, QoL domains evaluated PD QoL–39 scale (PDQ-39). Results: The was 37.33 ± 6.36 Majority male (66.12%)....
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BACKGROUND: Huntington disease (HD) is an inherited, neurodegenerative disorder, caused by the expansion of unstable CAG repeat sequence in HTT gene. The prevalence HD, allelic diversity, rate novel expansions, and clinical correlates, vary across populations. OBJECTIVE: To analyze diversity alleles their investigate instability trends within HD families, assess these findings context high sporadicity observed pedigree analysis. Also, to provide proof concept for occurrence de novo...
Abstract Background No objective biomarkers exist for diagnosing and classifying tremor syndromes. Objective The aim was to develop validate a deep learning (DL) algorithm tremors from hand‐drawn pen‐on‐paper spirals. Methods We recruited participants with dystonic (DT), essential (ET), plus (ETP), Parkinson's disease (PD), cerebellar ataxia (AT), healthy volunteers (HV). Participants drew free‐hand spirals on paper, which were used train DL based transfer using InceptionResNetV2 Keras...
Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive disorder caused by bi-allelic pathogenic variants in
Non-motor symptoms (NMSs) significantly contribute to increased morbidity and poor quality of life in patients with parkinsonian disorders. This study aims explore the profile NMSs progressive supranuclear palsy (PSP) using validated Non-Motor Symptom Scale (NMSS).Seventy-six PSP were evaluated this study. Motor Rating (PSPRS), Unified Parkinson's Disease Scale-III, Montreal Cognitive Assessment, Hamilton Depression (HAM-D) Anxiety Scales, Sleep (PDSS) NMSS. NMS severity prevalence also...
Objectives: Autoimmune neuronal synaptic encephalitis (AIE) encompasses a heterogeneous group of disorders characterized by immune-mediated cell destruction. In this study, we aim to study the clinical features, imaging profile and treatment outcome patients with AIE.Methods:This is chart review 16 (M: F-3:13) AIE from 2011 2015.Results:Among patients, 10 had anti-NMDA, 4 anti-TPO, 2 anti-VGKC antibody positivity. Cognitive impairment seizures were predominant symptoms present in nearly all...
Abstract Background: Psychogenic movement disorders (PMD) is a group of that cannot be attributed to any structural or biochemical abnormality, but has an underlying psychiatric illness. The profile PMD varies according country and socioeconomic factors. Methods: present study reports the clinical patients with from India. Seventy-three documented clinically established were seen over period 14 years detailed neurological examinations. Results: mean age at presentation was 29.1±15.1 (women,...
Objective The non-motor manifestations of motor predominant disorders have been an area active interest in recent times. objective the study was to determine prevalence symptoms patients with genetically confirmed spinocerebellar ataxia (SCA). Materials and Methods Forty-one SCA 48 age-, gender-, education-matched controls were included. severity evaluated using International Cooperative Ataxia Rating Scale (ICARS) cognitive impairment a neuropsychological battery. Non-motor features...
Abstract Background About 70–90% of Parkinson's disease (PD) patients have olfactory deficits which is considered as pre‐motor symptom PD. Lewy bodies been demonstrated in the bulb (OB) Objective To assess OB volume (OBV), sulcus depth (OSD) PD and compare with progressive supranuclear palsy (PSP), multiple system atrophy (MSA) vascular parkinsonism (VP) determine cut‐off that will aid diagnosis Methods This was a cross‐sectional, hospital based, single‐center study. Forty PD, 20 PSP, 10...
The novel coronavirus disease (COVID-19) pandemic and public health measures to control it have resulted in unique challenges the management of patients with deep brain stimulation (DBS). We report our experience acute worsening symptoms due battery exhaustion 3 DBS.Patients DBS for movement disorders who visited emergency room during nationwide lockdown from April May 2020 were included.Two subthalamic nucleus-DBS Parkinson's (PD) one globus pallidus interna-DBS generalized dystonia...