A5044492826- Systemic Sclerosis and Related Diseases
- Systemic Lupus Erythematosus Research
- Inflammatory Myopathies and Dermatomyositis
- Dermatologic Treatments and Research
- Rheumatoid Arthritis Research and Therapies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Monoclonal and Polyclonal Antibodies Research
- Vasculitis and related conditions
- Skin Diseases and Diabetes
- Autoimmune and Inflammatory Disorders Research
- Connective Tissue Growth Factor Research
- Sustainable Development and Environmental Management
- Adipokines, Inflammation, and Metabolic Diseases
- Urticaria and Related Conditions
- Growth Hormone and Insulin-like Growth Factors
- Medical Imaging and Pathology Studies
- Multiple Sclerosis Research Studies
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunodeficiency and Autoimmune Disorders
- Atherosclerosis and Cardiovascular Diseases
- IgG4-Related and Inflammatory Diseases
- Building energy efficiency and sustainability
Poznan University of Medical Sciences
2012-2024
University of Łódź
2013-2014
Instytut Nauk Ekonomicznych
2014
Objectives The aim of our study was to determine whether there is a correlation between transcription factors expression and Th17/Treg ratio, cytokine profile in the RA phenotype as well identify that could be potential biomarker for RA. Methods conducted on 45 patients with RA, 27 OA 46 healthy controls (HCs). Th17 Treg frequency determined by flow cytometry (15 RA/OA 15 subjects HC). Gene estimated qPCR, serum levels were ELISA. Results percentage (CD4+CD25highCD127-) cells lower than or...
To evaluate the use of hydroxychloroquine (HCQ) and its impact on Health Assessment Questionnaire disability index(HAQ-DI) Cochin Hand Function Status(CHFS) in a large Systemic Sclerosis (SSc) cohort. SSc patients from European Scleroderma Trials Research (EUSTAR) database treated with HCQ for at least 6 months were evaluated compared to matched group not using HCQ. Demographic clinical data, concomitant drugs, HAQ-DI CHFS (at 2 evaluations) recorded outcome variables interest. Statistical...
MicroRNAs regulate gene expression of transcriptional factors, which influence Th17/Treg (regulatory T cells) balance, establishing the molecular mechanism genetic and epigenetic regulation Treg Th17 cells is crucial for understanding rheumatoid arthritis (RA) pathogenesis. The study goal was to understand potential impact selected microRNAs profiles on Treg/Th17 frequency, RA phenotype, profile microRNAs, their correlation with factors: SOCS1, SMAD3, SMAD4, STAT3, STAT5 in RA; we used...
Systemic lupus erythematosus (SLE) is a chronic relapsing autoimmune disease characterized by the presence of autoantibodies directed against nuclear antigens and inflammation. Although etiology SLE remains unclear, influence environment factors, which largely reflected epigenetic mechanisms, with DNA methylation changes in particular, generally considered as main players pathogenesis SLE. We studied methyltransferases' (DNMTs) type 1, 3A 3B transcript levels peripheral blood mononuclear...
Abstract Objective Interstitial lung disease (ILD) is the leading cause of morbidity and mortality in systemic sclerosis (SSc) patients. We aimed to investigate impact sex on SSc-ILD. Methods EUSTAR SSc patients with radiologically confirmed ILD available percentage predicted forced vital capacity (%pFVC) were included. Demographics features recorded. A change %pFVC over 12 months (s.d. 6) (cohort 1) was classified into stable (≤4%), mild (5–9%) large progression (≥10%). In those 2-year...
Cognitive impairment is a significant clinical problem both in multiple sclerosis (MS) and systemic lupus erythematosus (SLE) patients. In MS cognitive dysfunction has been associated with brain atrophy total demyelinating lesion volume. SLE much less understood, its link to structural damage remains be established. The aim of this study was identify the relationship between subcortical gray matter volume SLE. We recruited 37 38 patients matched by age, disease duration educational level....
The neuropsychological functioning of people with type 1 diabetes (T1D) is key importance to the effectiveness therapy, which, in its complexity, requires a great deal knowledge, attention, and commitment. Intellectual limitations make it difficult achieve optimal metabolic balance, lack this alignment can contribute further deterioration cognitive functions. aim study was provide narrative review current state knowledge regarding influence on brain structure functions during childhood also...
Systemic lupus erythematosus (SLE) is a chronic and systemic autoimmune disease. SLE described by production of autoantibodies causes damage many organs. T-cells play crucial role in pathogenesis. intensify inflammation through number processes, which leads to autoimmunization. CCR5 MECP2 genes are linked with pathogenesis SLE. Polymorphisms these related the prognostic factors risk disease onset severity. The aim this study was estimate influence polymorphisms on development course...
Retroperitoneal fibrosis (RPF) is a rare disease, characterized by inflammation and deposition of fibrotic tissue in the vicinity abdominal aorta iliac arteries. We present report five patients admitted to our department between January 2014 February 2017, diagnosed with RPF. Abdominal pain was most common presenting symptom; however, one patient, RPF identified accidentally routinely performed ultrasonography. In 4 cases, corticosteroids (CS) combination azathioprine were applied as...
Objectives Biologics are medications widely applied in the management of inflammatory rheumatic diseases. The drugs were found to be effective but their application is associated with some disadvantages. Medication biologics relatively expensive, and Poland, it carried out specialized centers. study was designed evaluate various aspects satisfaction dissatisfaction Polish patients treated biologics. Material methods An anonymous questionnaire distributed 23 rheumatological centers involved...
Insulin is one of the major factors regulating adipose tissue function. On other hand, adipocytes secrete adipocytokines that may influence insulin synthesis and action, are involved in blood glucose regulation. In type 1 diabetes mellitus (t1DM), beta cells function replaced with exogenous therapy. This raises a question concerning impact t1DM on secretory The aim this study was to evaluate adipocytokines, resistin, serum concentrations relation body fat mass children t1DM.The comprised 75...
Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease characterized by widespread soft tissue ossification and congenital stigmata of the extremities. We report case 33-year-old woman with clinical radiological features FOP. She was born bilateral hallux valgus at age 10 presented swelling left scapula. During course numerous crises were observed. In this patient authors noticed FOP exacerbation after surgical operation.
The study aimed to explore the pontential impact of 10 polymorphisms within IFN-α, IFN-β1, IFN-γ and TLR3 genes on SLE phenotype susceptibility relationship between specific genotypes clinics. Whole blood samples from patients healthy controls was obtained. DNA extracted peripheral by QIAamp Blood Mini Kit (Qiagen). quality quantity isolated estimated Quawell Q5000 spectrophotometer. We genotyped subjects using real-time PCR (QuantStudio 5 thermocycler). suggests that rs2069705, rs2069718...