A5053017282- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Systemic Sclerosis and Related Diseases
- Tracheal and airway disorders
- Amyotrophic Lateral Sclerosis Research
- Pleural and Pulmonary Diseases
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Asthma and respiratory diseases
- Neurogenetic and Muscular Disorders Research
- Lung Cancer Diagnosis and Treatment
- Obstructive Sleep Apnea Research
- Ultrasound in Clinical Applications
- Salivary Gland Tumors Diagnosis and Treatment
- Diagnosis and Treatment of Venous Diseases
- Cardiovascular and Diving-Related Complications
- Air Quality and Health Impacts
- Cardiovascular and exercise physiology
- Parkinson's Disease Mechanisms and Treatments
- Ferroptosis and cancer prognosis
- Liver Disease and Transplantation
- Genetic Syndromes and Imprinting
- Zebrafish Biomedical Research Applications
- Hemostasis and retained surgical items
Ospedale Antonio Cardarelli
2021-2023
Fatebenefratelli Hospital
2019-2022
University of Campania "Luigi Vanvitelli"
2010-2021
Presidio Ospedaliero
2018
University of Salerno
2014
ASL Roma
2010-2013
Azienda Ospedaliera Universitaria Pisana
2010
Ospedale Cisanello
2010
Cambridge University Press
2010
Objective. To assess internal organ involvement in early SSc at presentation. Methods. One hundred and fifteen patients admitted to a tertiary centre because of RP, who did not present any routinely detectable scleroderma-related involvement, were investigated for ANA videocapillaroscopy, underwent history physical examination detect symptoms/signs suggestive SSc. Patients then subdivided into three groups: (i) SSc, constituted by without clinical manifestations other than but with...
To investigate whether patients affected by 1 of the 3 subsets early systemic sclerosis (SSc; scleroderma), i.e., subset I, Raynaud's phenomenon with SSc marker autoantibodies and typical capillaroscopic findings; II, autoantibody positive only; III, capillaroscopy only not satisfying 2013 American College Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria for at admission, differ from each other in time to satisfy criteria.Early subdivided into indicated...
Abstract Background Many asthmatic women complain of symptom exacerbations in particular periods, i.e. during pregnancy and menstrual cycles (perimenstrual asthma: PMA)". The goal this study was to the effect luteal follicular phases cycle on bronchial reactivity (BR) a group women. Methods For purpose, 36 pre-menopausal were enrolled underwent testing for resting pulmonary function, measurement diffusing capacity lung carbon monoxide (DLCO), airway responsiveness methacholine their cycles....
Abstract Programmed Death Ligand 1 (PD-L1) is crucial in regulating the immunological tolerance non-small cell lung cancer (NSCLC). Alveolar macrophage (AM)-derived PD-L1 binds to its receptor, PD-1, on surveilling lymphocytes, leading lymphocyte exhaustion. Increased expression associated with cigarette smoke (CS)-exposure. However, role CS-associated diseases NSCLC, such as chronic obstructive pulmonary disease (COPD), still unclear. In two different cohorts of ever smokers COPD or and...
Abstract Background and purpose Many studies unequivocally indicate that air pollution is directly linked to the adverse cardiovascular outcomes in general population. No data are currently available on effects of exposure trafficked roads healthy children. Distance residence a major road has been shown be useful proxy for long-term traffic seem more consistently associated with atherosclerosis than particulate matter 2.5 . The aim this study was investigate possible association between...
Early systemic sclerosis (SSc) is characterized by Raynaud's phenomenon together with scleroderma marker autoantibodies and/or a pattern at capillaroscopy and no other distinctive feature of SSc. Patients presenting plus capillaroscopic seem to evolve into definite SSc more frequently than patients either feature. Whether early only or positivity differ in any aspect presentation unclear. Seventy-one consecutive were investigated for preclinical cardiopulmonary alterations. Out these, 44 25...
We investigated early systemic sclerosis (SSc) (that is, Raynaud's phenomenon with SSc marker autoantibodies and/or typical capillaroscopic findings and no manifestations other than puffy fingers or arthritis) versus undifferentiated connective tissue disease (UCTD) to identify predictors of short-term evolution.Thirty-nine 37 UCTD patients were investigated. At baseline, all underwent clinical evaluation, B-mode echocardiography, lung function tests esophageal manometry detect preclinical...
To investigate the prevalence of impaired exercise performance as assessed by a standardized cardiopulmonary test (CPET) in systemic sclerosis (SSc) and to identify associated disease features.Forty-six SSc patients were enrolled evaluated for clinical serological subset, extent skin internal organ involvement, activity severity. Exercise was subsequently these 23 healthy individuals matched sex age, using CPET.Exercise performance, measured maximum oxygen uptake (VO2 max < 80% predicted...
Obesity is a risk factor for sleep disordered breathing (SDB) in children. Plasma levels of high-sensitivity C-reactive protein (Hs-CRP) are predictive cardiovascular morbidity adults, and CRP associated with over-weight. Increased carotid intima-media thickness (IMT) several factors. We evaluated the effect SDB on IMT lean obese children not selected snoring.101 (age 5-15 years) attending weight clinic or scheduled routine visit. was measured quantitative B-mode ultrasound scans. The...
Background: Bronchoscopic lung volume reduction (BLVR) with implant of one-way endobronchial valves (EBV) is a feasible treatment for management heterogeneous emphysema (HE) clinical benefits in the early follow-up. We aimed to evaluate long-terms results and safety this procedure consecutive series patients HE. Methods: It was retrospective single center study including all HE undergoing EBV completing at least 5 years long-term Patients were splitted into Collapse No-Collapse Group if...
Respiratory diseases in Italy already now represent an emergency (they are the 3rd ranking cause of death world, and 2nd if Lung cancer is included). In countries similar to our own, they result as principal for a visit general practitioner (GP) second main after injury recourse Emergency Care. Their frequency probably higher than estimated (given that respiratory currently underdiagnosed). The trend towards further increase due epidemiologic demographic factors (foremost amongst which...
We proposed a new virtual bronchoscopy tool to improve the accuracy of traditional transbronchial needle aspiration for mediastinal staging.Chest-computed tomographic images (1 mm thickness) were reconstructed with Osirix software produce bronchoscopic simulation. The target adenopathy was identified by measuring its distance from carina on multiplanar reconstruction images. static uploaded in iMovie Software, which produced movie images; then transferred tablet computer provide real-time...
Background: To evaluate the feasibility of a combined strategy including conventional-trans-bronchial needle aspiration biopsy (C-TBNA) and endobronchial ultrasounds transbronchial (EBUS-TBNA) for sampling mediastinal adenopathies in patients with lung cancer order to determinate whether era ultrasound technology C-TBNA could still play role staging. Methods: It was retrospective multicenter study all consecutive radiological undergoing TBNA staging (January 2014 – July 2016). performed as...
Abstract We reported the role of endobronchial ultrasound as complement to standard diagnostic exams better define benign tracheal stenosis (i.e., thickness and cartilage integrity) plan treatment with flexible instead rigid bronchoscope. Under sedation spontaneous ventilation, bronchoscope was inserted through laryngeal mask airway that assured ventilation. The first resected cold scissors then dilated balloon catheter. This strategy successfully applied in five consecutive patients....
The current diagnostic criteria for amyotrophic lateral sclerosis (ALS) may remain unsatisfactory months or years in the early disease. Pulmonary assessment has never been considered useful diagnosis of ALS, and studies pulmonary function this patient category are lacking.
The diagnostic criterion for amyotrophic lateral sclerosis (ALS) based on the findings of concomitant clinical and electrophysiological evidence upper lower motor neuron involvement may remain unsatisfied months in some patients, even years early stage disease. Since respiratory is an onset symptom ALS only 1-3% pulmonary assessment has never been considered useful diagnosis ALS. However, studies function are lacking, especially those stages where neurologic tests also inconclusive. In...