A5006597602- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Thyroid Disorders and Treatments
- Bone health and treatments
- Bone health and osteoporosis research
- Muscle metabolism and nutrition
- Metabolism, Diabetes, and Cancer
- Cancer, Hypoxia, and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Diet and metabolism studies
- Biochemical effects in animals
- Metabolism and Genetic Disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Bone Metabolism and Diseases
- Metabolomics and Mass Spectrometry Studies
- Exercise and Physiological Responses
- Liver Disease Diagnosis and Treatment
- ATP Synthase and ATPases Research
- Monoclonal and Polyclonal Antibodies Research
- High Altitude and Hypoxia
- Bone and Joint Diseases
- Cardiovascular Disease and Adiposity
- Sirtuins and Resveratrol in Medicine
- Diet, Metabolism, and Disease
- Regulation of Appetite and Obesity
University of Naples Federico II
2014-2024
Istituto Nazionale di Fisica Nucleare, Sezione di Napoli
2022
Federico II University Hospital
2001-2021
University of Campania "Luigi Vanvitelli"
2018
Merck & Co., Inc., Rahway, NJ, USA (United States)
1999-2015
University of Sannio
2006-2012
Institute for Experimental Endocrinology and Oncology
2011
Lombardia Informatica (Italy)
2009
In-Q-Tel
2009
Physiologie Environnement et Génétique pour l'Animal et les Systèmes d'Elevage
2000
Alendronate, an aminobisphosphonate, is much more potent than etidronate, older bisphosphonate, in inhibiting osteoclast-mediated bone resorption, and unlike therapeutic doses of alendronate are not associated with abnormal mineralization. In the present study, we compared effectiveness, safety, tolerability 6 months daily oral administration (40 mg) those etidronate (400 89 patients clinically active Paget's disease. The primary efficacy end point was percent change serum alkaline...
abstract Context: Information on the use of oral bisphosphonate agents to treat pediatric osteogenesis imperfecta (OI) is limited. Objective: The objective investigation was study efficacy and safety daily alendronate (ALN) in children with OI. Design Participants: We conducted a multicenter, double-blind, randomized, placebo-controlled study. One hundred thirty-nine (aged 4–19 yr) type I, III, or IV OI were randomized either placebo (n = 30) ALN 109) for 2 yr. doses 5 mg/d less than 40 kg...
Odanacatib is a cathepsin K inhibitor investigated for the treatment of postmenopausal osteoporosis. Phase 2 data indicate that 50 mg once weekly inhibits bone resorption and increases mineral density, with only transient decrease in formation. We describe background, design participant characteristics phase 3 registration trial.
Distinct brain peptidergic circuits govern peripheral energy homeostasis and related behavior. Here we report that mitochondrial uncoupling protein 2 (UCP2) is expressed discretely in neurons involved homeostatic regulation. UCP2 was associated with the mitochondria of neurons, predominantly axons axon terminals. UCP2-producing were found to be targets hormones, including leptin gonadal steroids, presence axonal processes predicted increased local activity heat production. In hypothalamus,...
ABSTRACT The effect of thyroid hormones on metabolism has long supported their potential as drugs to stimulate fat reduction, but the concomitant induction a thyrotoxic state greatly limited use. Recent evidence suggests that 3,5‐diiodo‐ L ‐thyronine (T 2 ), naturally occurring iodothyronine, stimulates metabolic rate via mechanisms involving mitochondrial apparatus. We examined whether this would result in reduced energy storage. Here, we show T administration rats receiving high‐fat diet...
Although the first evidence of a relationship between thyroid and metabolism was reported in 1895, mechanism by which hormones influence resting metabolic rate whole animals is still poorly understood. This paper reports an attempt to test whether diiodothyronines (T 2 s) triiodothyronine 3 ) have different roles control (RM). Changes were measured hypothyroid rats treated acutely (25μg (100 g body weight) −1 either with one T s or . Injection induced increase about 35% RM that started 25–30...
OBJECTIVE High-fat diets (HFDs) are known to induce insulin resistance. Previously, we showed that 3,5-diiodothyronine (T2), concomitantly administered rats on a 4-week HFD, prevented gain in body weight and adipose mass. Here investigated whether how T2 HFD-induced RESEARCH DESIGN AND METHODS We the biochemical targets of related lipid glucose homeostasis over time using various techniques, including genomic proteomic profiling, immunoblotting, transient transfection, enzyme activity...
Long-term treatment studies showed that the therapeutic effects of alendronate (ALN) were sustained over a 10-year period. However, data on intrinsic bone material properties by long-term reduction turnover are still sparse. We analyzed transiliacal biopsies subgroup 30 Fracture Intervention Trial Long-Term Extension (FLEX) participants (n = 6 treated for 10 years with ALN at dose mg/day, n 5 and 14 plus further placebo) quantitative backscattered electron imaging (qBEI) scanning small-angle...
Metabolic dysfunction-associated fatty liver disease (MAFLD) is defined as the presence of hepatic steatosis in addition to one three metabolic conditions: overweight/obesity, type 2 diabetes mellitus, or dysregulation. Chronic exposure excess dietary acids may cause and disturbances. The alteration quality mitochondria factors that could contribute dysregulation MAFDL. This study was designed determine, a rodent model MAFLD, effects long-term high-fat diet (HFD) on some processes...
Thyroid hormones increase energy expenditure, partly by reducing metabolic efficiency. The control of specific genes at the transcriptional level is thought to be major molecular mechanism. However, both number and identity thyroid hormone-controlled remain unknown, as do their relative contributions. Uncoupling protein-3, a recently identified member mitochondrial transporter superfamily one that predominantly expressed in skeletal muscle, has potential determinant for thermogenesis....
We sought a correlation between rat skeletal muscle triiodothyronine (T3)‐mediated regulation of uncoupling protein‐3 (UCP3) expression and mitochondrial activity. UCP3 mRNA increased strongly during the hypothyroid‐hyperthyroid transition. The rank order State 3 4 respiration rates was hypothyroid<euthyroid<hyperthyroid. increase may have been due to expression, as proton leak kinetic stimulated in transition good exists level. As significant proportion an organism's resting oxygen...
The possible regulation of the expression uncoupling protein-2 (UCP2) mRNA by thyroid hormones in different tissues was examined rats. Triiodothyronine (T3) found to produce an organ-specific enhancement UCP2 rat tissues. effect T3 markedly observed heart, whereas a moderate seen skeletal muscle and no kidney or liver. These results suggest that is protein may be involved nuclear-mediated on resting metabolic rate rat.
Recent evidence indicates that human thyroid peroxidase (TPO) has most of the characteristics microsomal antigen. The question whether TPO accounts for part or all antigenic activity recognized by circulating anti-microsomal antigen autoantibody (anti-M Ab) remains to be determined. availability an anti-TPO monoclonal antibody and a highly purified preparation allowed development specific sensitive radioassays (anti-TPO Ab). In this study we compared anti-M Ab levels in serum from 128...
Triiodothyronine regulates energy metabolism and thermogenesis. Among triiodothyronine derivatives, 3,5-diiodo-l-thyronine (T 2 ) has been shown to exert marked effects on by acting mainly at the mitochondrial level. Here we investigated capacity of T affect both skeletal muscle substrate oxidation thermogenesis within 1 h after its injection into hypothyroid rats. Administration induced an increase in when palmitoyl-CoA (+104%), palmitoylcarnitine (+80%), or succinate (+30%) was used as...
The worldwide prevalence of obesity-associated pathologies, including type 2 diabetes, requires thorough investigation mechanisms and interventions. Recent studies have highlighted thyroid hormone analogs derivatives as potential agents able to counteract such pathologies. In this study, in rats receiving a high-fat diet (HFD), we analyzed the effects 4-wk daily administration naturally occurring iodothyronine, 3,5-diiodo-L-thyronine (T2), on gastrocnemius muscle metabolic/structural...