A5014145518- Venous Thromboembolism Diagnosis and Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Peripheral Artery Disease Management
- Lipoproteins and Cardiovascular Health
- Diagnosis and Treatment of Venous Diseases
- Acute Myocardial Infarction Research
- Central Venous Catheters and Hemodialysis
- Acute Ischemic Stroke Management
- Systemic Sclerosis and Related Diseases
- Platelet Disorders and Treatments
- Vascular Procedures and Complications
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Arrhythmias and Treatments
- Diabetes Treatment and Management
- Coronary Interventions and Diagnostics
- Cerebrovascular and Carotid Artery Diseases
- Sepsis Diagnosis and Treatment
- Chemotherapy-related skin toxicity
- Heparin-Induced Thrombocytopenia and Thrombosis
- COVID-19 Clinical Research Studies
- Neutropenia and Cancer Infections
- Stroke Rehabilitation and Recovery
- Electronic Health Records Systems
- Blood Coagulation and Thrombosis Mechanisms
Società Italiana di Cardiologia
2016-2021
Azienda Ospedaliera di Desio e Vimercate
2008-2020
University of Milan
2020
Pathways Behavioral Services
2019
National Student Clearinghouse Research Center
2018
Hôpital Roger Salengro
2017
Université Paris Cité
2017
Erasmus MC
2017
University of Nottingham
2017
University of Debrecen
2017
We conducted a controlled multicenter trial with central randomization and evaluation of events under blind conditions involving 652 patients unstable angina. Patients were treated either conventional therapy alone (group C) (n = 338) or combined an inhibitor platelet aggregation, ticlopidine 250 mg b.i.d. C + T) 314). assigned randomly within 48 hours admission followed up for 6 months. With the "intention-to-treat" approach, primary end points, vascular death nonfatal myocardial...
Although thromboprophylaxis reduces the incidence of venous thromboembolism in acutely ill medical patients, an associated reduction rate death from any cause has not been shown.We conducted a double-blind, placebo-controlled, randomized trial to assess effect subcutaneous enoxaparin (40 mg daily) as compared with placebo--both administered for 10±4 days patients who were wearing elastic stockings graduated compression--on among hospitalized, at participating sites China, India, Korea,...
AimsTo assess different aspects of the definition valvular/non-valvular atrial fibrillation (AF) used in clinical practice by physicians who usually treat this condition.
Sophisticated evidence-based information resources can filter medical evidence from the literature, integrate it into electronic health records, and generate recommendations tailored to individual patients.To assess effectiveness of a computerized clinical decision support system (CDSS) that preappraises provides professionals with actionable, patient-specific at point care.Open-label, parallel-group, randomized trial among internal medicine wards large Italian general hospital. All analyses...
Summary Platelet aggregation and fibrinogen binding were studied in 15 individuals before 7 days after the oral administration of ticlopidine (250 mg b.i.d.). Ticlopidine significantly inhibited platelet induced by adenosine diphosphate (ADP), endoperoxide analogue U46619, collagen or low concentrations thrombin, but did not inhibit epinephrine high thrombin. 125I-fibrinogen ADP, U46619 thrombin (1 U/ml). The ADP scavengers apyrase CP/CPK, added vitro to suspensions obtained ticlopidine,...
To see whether D-Dimer levels can identifying patients at high risk of venous thrombotic events and establish the best benefit/risk-of-bleeding ratio. Current guidelines do not recommend routine prophylaxis against thromboembolism (VTE) in cancer receiving chemotherapy, but increases about 6.5-fold because this treatment. D-dimer was measured baseline 124 scheduled for their first chemotherapy. VTE events, including symptomatic episodes deep vein thrombosis or pulmonary embolism both, were...
Vitamin K Antagonists (VKAs) are widely used in clinical practice and nearly 1% of the entire population receives oral anticoagulation at least once life. However, rate prescription is low, compared to what it should be. No more than 50-60% patients affected by atrial fibrillation (AF) receive anticoagulation. In setting AF, VKAs safe effective when properly managed, reducing stroke systemic embolism 60%. safety effectiveness closely related quality (e.g. time therapeutic range), clinics...
To develop and externally validate a prediction model for major bleeding in patients with TIA or ischemic stroke on antiplatelet agents.We combined individual patient data from 6 randomized clinical trials (CAPRIE, ESPS-2, MATCH, CHARISMA, ESPRIT, PRoFESS) investigating therapy after stroke. Cox regression analyses stratified by trial were performed to study the association between predictors bleeding. A risk was derived validated PERFORM trial. Performance assessed c statistic calibration...
The CAPRIE study showed the superiority of clopidogrel over acetylsalicylic acid (ASA) for reducing combined risk major atherothrombotic events in patients with recent myocardial infarction (MI), ischaemic stroke (IS) or established peripheral arterial disease. benefit ASA is amplified high-risk patients. Proof concept addition to coronary manifestations atherothrombosis was provided by CURE trial.MATCH a randomized, double-blind, placebo-controlled trial that compares and versus alone...
Elastic compression stockings are useful for preventing post-thrombotic syndrome after deep venous thrombosis (DVT). Less is known about their effects on thrombus recanalization and the optimal timing starting compression. This study investigated whether applied early was more effective than when started 2 weeks DVT. Seventy-three patients with DVT were randomly assigned to elastic hosiery either immediately diagnosis or later. After 14 90 days residual measured by ultrasonography, patency...