A5083704334- Acute Ischemic Stroke Management
- Antiplatelet Therapy and Cardiovascular Diseases
- Atrial Fibrillation Management and Outcomes
- Cerebrovascular and Carotid Artery Diseases
- Intracerebral and Subarachnoid Hemorrhage Research
- Venous Thromboembolism Diagnosis and Management
- Blood Pressure and Hypertension Studies
- Dementia and Cognitive Impairment Research
- Cardiovascular Health and Disease Prevention
- Stroke Rehabilitation and Recovery
- Lung Cancer Treatments and Mutations
- Nutritional Studies and Diet
- Brain Metastases and Treatment
- Health disparities and outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Cognitive Abilities and Testing
- Cardiovascular and Diving-Related Complications
- Advanced MRI Techniques and Applications
- Neurosurgical Procedures and Complications
- Lung Cancer Research Studies
- Behavioral and Psychological Studies
- Intracranial Aneurysms: Treatment and Complications
- Chemical Reactions and Isotopes
- MRI in cancer diagnosis
- Cardiovascular Syncope and Autonomic Disorders
Radboud University Medical Center
2016-2024
Radboud University Nijmegen
2016-2024
University Medical Center Utrecht
2015-2024
Medical Research Council
2024
University of Bristol
2024
University Medical Center
2023
Luzerner Kantonsspital
2022
Roche (Switzerland)
2022
Utrecht University
2017-2021
University of Debrecen
2017-2018
Objective A substantial part of non-traumatic intracerebral haemorrhages (ICH) arises from a macrovascular cause, but there is little guidance on selection patients for additional diagnostic work-up. We aimed to develop and externally validate model predicting the probability cause in with ICH. Methods The DIagnostic AngioGRAphy find vascular Malformations (DIAGRAM) study (n=298; 69 cause; 23%) prospective, multicentre assessing yield accuracy CT angiography (CTA), MRI/ magnetic resonance...
Introduction Patients with acute stroke are at high risk for infection. These infections associated unfavourable outcome after stroke. A prediction rule can identify the patients highest strategies to prevent We aim develop a post-stroke pneumonia and other in methods used data from Preventive Antibiotics Stroke Study, multicentre randomised trial comparing preventive ceftriaxone vs. standard care Possible predictors or infection were selected literature. Backward elimination logistic...
Importance Cause of ischemic stroke in young people is highly variable; however, the risk recurrence often presented with all subtypes grouped together classification systems such as Trial ORG (danaparoid sodium [Orgaran]) 10172 Acute Stroke Treatment (TOAST) criteria, which limits ability to individually inform patients about their recurrence. Objective To determine short-term and long-term recurrent vascular events after at a age by cause identify factors associated Design, Setting,...
To develop and externally validate a prediction model for major bleeding in patients with TIA or ischemic stroke on antiplatelet agents.We combined individual patient data from 6 randomized clinical trials (CAPRIE, ESPS-2, MATCH, CHARISMA, ESPRIT, PRoFESS) investigating therapy after stroke. Cox regression analyses stratified by trial were performed to study the association between predictors bleeding. A risk was derived validated PERFORM trial. Performance assessed c statistic calibration...
High blood pressure variability (BPV) may be a risk factor for stroke and dementia in patients with ischemic stroke, but the underlying mechanism is unknown. We aimed to investigate whether high BPV associated presence progression of white matter hyperintensities (WMH).
There is evidence that blood pressure variability (BPV) associated with cerebral small vessel disease (SVD) and may therefore increase the risk of stroke dementia. It remains unclear if BPV SVD progression over years. We examined whether visit-to-visit white matter hyperintensity (WMH) 14 years MRI markers after
To investigate the association between blood pressure (BP) levels and risk of intracerebral hemorrhage (ICH) after ischemic stroke.We performed a post hoc analysis data from Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial, randomized clinical trial including 20,332 patients with recent noncardioembolic stroke. BP measurements were divided into predefined categories. We calculated incidence rates per category multivariable Cox regression systolic (SBP) diastolic...
Patent foramen ovale (PFO) is a congenital anatomical variant which associated with strokes in young adults. Contrary to vascular risk factors and atherosclerosis, PFO present from birth. However, it completely unknown how an structure that already at birth large proportion of the population can convert into causes stroke few. Recent studies reported significant association between certain trigger ischemic This study aims investigate these triggers PFO-associated stroke.
The S2TOP-BLEED score may help to identify patients at high risk of bleeding on antiplatelet drugs after a transient ischemic attack or stroke. was derived trial populations, and its performance in real-world setting is unknown. We aimed externally validate the for major population-based cohort compare with other scores bleeding.We studied 2072 stroke agents OXVASC (Oxford Vascular Study) according 3 scores: S2TOP-BLEED, REACH, Intracranial-B2LEED3S. Performance assessed C statistics...
Lifelong treatment with antiplatelet drugs is recommended following a transient ischemic attack or stroke. Bleeding complications may offset the benefit of in patients at increased risk bleeding and low recurrent events. We aimed to investigate net according an individuals’ risk.We pooled individual patient data from 6 randomized clinical trials (CAPRIE [Clopidogrel Versus Aspirin Patients Risk Ischemic Events], ESPS-2 [European Stroke Prevention Study-2], MATCH [Management Atherothrombosis...
Performance of risk scores for major bleeding in patients with atrial fibrillation and a previous transient ischemic attack or stroke is not well established. We aimed to validate treated oral anticoagulants after cerebral ischemia explore the net benefit among categories.We analyzed 3623 history included RE-LY trial (Randomized Evaluation Long-Term Anticoagulation Therapy). assessed performance HEMORR2HAGES (hepatic renal disease, ethanol abuse, malignancy, older age, reduced platelet count...
Importance High visit-to-visit blood pressure variability (BPV) in late life may reflect increased dementia risk better than mean systolic (SBP). Evidence from midlife to could be crucial understanding this association. Objective To determine whether BPV at different ages was differentially associated with lifetime incident community-dwelling individuals. Design, Setting, and Participants This cohort study analyzed data the Adult Changes Thought (ACT) study, an ongoing population-based...
Objective: High blood pressure and variability are potential, modifiable risk factors of poststroke dementia. We aimed to investigate the association between achieved pressure, Methods: studied 17 064 patients with noncardioembolic ischemic stroke included in Prevention Regimen for Effectively avoiding Second Strokes (PRoFESS) trial. analysed data as a single observational cohort. mean SBP DBP defined coefficient variation (SD/mean∗100). The dementia was investigated logistic regression...
It is unknown which patients with non-traumatic isolated intraventricular hemorrhage should undergo angiographic imaging to detect an underlying macrovascular cause and modality has the highest yield. We studied yield of examinations in hemorrhage.We reviewed medical records admitted University Medical Center Utrecht between 2002 2012. searched PubMed Embase for studies on until January 2014. calculated investigated influence age, hypertension anticoagulant use meta-regression analysis.We...
Guidelines recommend antithrombotic medication as secondary prevention for patients with ischemic stroke or transient attack (TIA) at young age based on results from trials in older patients. We investigated the long-term risk of bleeding and events after TIA.We included 30-day survivors first-ever TIA aged 18-50 years Follow-Up Stroke Patients Unelucidated Risk Factor Evaluation (FUTURE) study, a prospective cohort study age. obtained information recurrent ischemia structured data...
Mediation analysis can be applied in medical research with the aim of understanding pathways that operate between an exposure and its effects on outcome. This method help to improve our pathophysiologic mechanisms may guide choice potential treatment strategies. Traditional mediation decomposes total effect intervention outcome into 2 effects: (1) indirect effect, from using a mediator outcome, (2) direct directly A limitation this is it assumes no interaction mediator, which either lead...
Multiple studies found a higher ischemic stroke incidence in rural areas compared with urbanized areas, often explained by low socioeconomic status (SES). However, this has rarely been investigated specifically younger adults. We aimed to investigate the age-specific (15-49 years vs 50+ years) of and municipalities within Netherlands. Patients first-ever (15 or older) between 1998 2018 were included registry-based study through linkage Dutch national hospital administrative registries....
Bleeding is the main safety concern of treatment with antiplatelet drugs. We aimed to refine prediction major bleeding on after a transient ischaemic attack (TIA) or stroke by assessing added value new predictors existing S2TOP-BLEED score.We used Cox regression analysis study association between candidate and among 2072 patients included in population-based (Oxford Vascular Study - OXVASC). An updated model was proposed validated 1094 myocardial infarction OXVASC. Models were compared...
Abstract There is evidence that blood pressure variability (BPV) associated with cerebral small vessel disease (SVD) and may therefore increase the risk of stroke dementia. It remains unclear if BPV SVD progression over years. We examined whether visit-to-visit White Matter Hyperintensity (WMH) 14 years MRI markers after included participants from Radboud University Nijmegen Diffusion tensor Magnetic resonance imaging Cohort (RUNDMC) who underwent baseline assessment in 2006 follow-up 2011,...