A5035754541- Parkinson's Disease Mechanisms and Treatments
- Neurological disorders and treatments
- Health Systems, Economic Evaluations, Quality of Life
- Dementia and Cognitive Impairment Research
- Autism Spectrum Disorder Research
- Chronic Disease Management Strategies
- Balance, Gait, and Falls Prevention
- Cerebral Palsy and Movement Disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Dysphagia Assessment and Management
- Nuclear Receptors and Signaling
- Sex and Gender in Healthcare
- Alzheimer's disease research and treatments
- Stroke Rehabilitation and Recovery
- Ginkgo biloba and Cashew Applications
- Genetic Neurodegenerative Diseases
- Pesticide Exposure and Toxicity
- Restless Legs Syndrome Research
- Assistive Technology in Communication and Mobility
- Long-Term Effects of COVID-19
- Obesity, Physical Activity, Diet
- Nutritional Studies and Diet
- Older Adults Driving Studies
- Botulinum Toxin and Related Neurological Disorders
Radboud University Nijmegen
2018-2025
Radboud University Medical Center
2018-2025
University Medical Center
2021-2024
Allen Institute for Brain Science
2023-2024
Medical Research Council
2024
University of Bristol
2024
Centre for Movement Disorders
2021-2023
Utrecht University
2023
The Ohio State University Wexner Medical Center
2023
University of Pittsburgh
2023
<h3>Objective</h3> To determine changes in the incidence of dementia between 1988 and 2015. <h3>Methods</h3> This analysis was performed aggregated data from individuals >65 years age 7 population-based cohort studies United States Europe Alzheimer Cohort Consortium. First, we calculated age- sex-specific rates for all-cause dementia, then defined nonoverlapping 5-year epochs within each study to trends incidence. Estimates change per 10-year interval were pooled results are presented...
See Breen and Lang (doi:10.1093/aww321) for a scientific commentary on this article. At the time of clinical diagnosis, patients with Parkinson's disease already have wide range motor non-motor features that affect their daily functioning. However, temporal sequence occurrence these remains largely unknown. We studied trajectories functioning in 23 years preceding diagnosis by performing nested case-control study within prospective Rotterdam study. Between 1990 2013, we repeatedly performed...
Abstract Introduction Falling is among the most serious clinical problems in Parkinson's disease (PD). We used body‐worn sensors (falls detector worn as a necklace) to quantify hazard ratio of falls PD patients real life. Methods matched all 2063 elderly individuals with self‐reported without based on age, gender, comorbidity, and living conditions. analyzed fall events collected at home via wearable sensor. Fall were either automatically using or registered by button push same device....
Sleep disturbances may signal presence of prodromal parkinsonism, including Parkinson's disease. Whether general sleep quality or duration in otherwise healthy subjects is related to the risk parkinsonism remains unclear. We hypothesized that both worse self-reported and duration, as well a longitudinal deterioration these measures, are associated with In prospective population-based Rotterdam Study, we assessed Pittsburgh Quality Index 7726 (mean age 65 years, 57% female) between 2002 2008,...
Providing informal care for a person with Parkinson's disease (PD) can be demanding process affecting several dimensions of caregiver's life and potentially causing caregiver burden. Despite the emerging literature on burden in people PD, little is known about inter-relationship between quantitative qualitative findings. Filling this knowledge gap will provide more holistic approach to develop design innovations aiming at reducing or even preventing This study aimed characterize determinants...
Digital biomarkers that remotely monitor symptoms have the potential to revolutionize outcome assessments in future disease-modifying trials Parkinson's disease (PD), by allowing objective and recurrent measurement of signs collected participant's own living environment. This biomarker field is developing rapidly for assessing motor features PD, but non-motor domain lags behind. Here, we systematically review assess digital under development measuring PD. We also consider relevant...
Physical activity has beneficial symptomatic effects for people with Parkinson's disease (PD), but increasing-and sustaining-a physically active lifestyle remains challenging. We investigated the feasibility (ability to increase step counts) and usability of a behavioral intervention using motivational smartphone application remotely physical in PD. performed 4-week, double-blind pilot trial. Thirty PD who were able walk independently did not take more than 7000 steps at baseline randomized...
Abstract Background Conventional medical management, while essential, cannot address all multifaceted consequences of Parkinson’s disease (PD). This pilot study explores the potential a co-designed creative arts therapy on health-related quality life, well-being, and pertinent non-motor symptoms. Methods We conducted an exploratory with pre-post design using validated questionnaires. Eight individuals PD participated in program. The investigated intervention was 10-week weekly 90–120-min...
ABSTRACT Sarcopenia, a complex multifactorial condition, is characterized by loss of muscle mass and function, which increases progressively with age. The existence different definitions has contributed to the large variation in prevalence estimates sarcopenia. We aimed estimate sarcopenia general population using European Working Group on Sarcopenia Older People (EWGSOP) proposed definition compared baseline demographic clinical characteristics between nonsarcopenia, presarcopenia,...
Cognitive dysfunction is a common feature among patients with parkinsonism, including Parkinson disease (PD). However, there scarcity of data on cognitive functioning before parkinsonism diagnosis, stage at which may still respond to putative disease-modifying interventions.To assess whether poor associated an increased risk parkinsonism.Between January 8, 2002, and December 14, 2008, baseline function was assessed in 7386 participants the Rotterdam Study who were free dementia. Four tests...
Objective To quantify the burden of common neurological disease in older adults terms lifetime risks, including their co-occurrence and preventive potential, within a competing risk framework. Methods Within prospective population-based Rotterdam Study, we studied dementia, stroke parkinsonism between 1990 2016. Among 12 102 individuals (57.7% women) aged ≥45 years free from these diseases at baseline, co-occurrence, quantified combined, disease-specific remaining various ages for men women...
The prevalence of Parkinson disease (PD) is growing fast, amplifying the quest for disease-modifying therapies in early phases where pathology still limited. Lifestyle interventions offer a promising avenue preventing progression from prodromal to manifest PD. We illustrate this primarily 1 specific lifestyle intervention, namely aerobic exercise because case other main factor (dietary interventions) modify course PD currently less persuasive. Various observations have hinted at potential...
Abstract Parkinson’s disease (PD) is a chronic, progressive and disabling neurodegenerative disorder. The prevalence of PD has risen considerably over the past decades. A growing body evidence suggest that exposure to environmental toxins, including pesticides, solvents heavy metals (collectively called toxins), at least in part responsible for this rapid growth. It worrying current screening procedures being applied internationally test possible neurotoxicity specific compounds offer...
Rationale: Chronic obstructive pulmonary disease (COPD) is a common, complex multisystem in the elderly with multiple comorbidities that significantly impact morbidity and mortality. Although cerebral small-vessel an important cause of cognitive decline age-related disability, it poorly investigated potential systemic manifestation patients COPD.Objectives: To examine whether COPD relates to development location microbleeds, novel marker disease.Methods: Cross-sectional longitudinal analyses...
Background and Purpose— It remains undetermined whether the use of coumarin anticoagulants associates with cerebral microbleeds in general population. We investigated (1) relates to higher prevalence incidence microbleeds, (2) are more frequent people maximum international normalized ratios (INRs), (3) among users, variability INR microbleed presence. Methods— From population-based Rotterdam Study, 4945 participants aged ≥45 years were included cross-sectional analysis, 3069 had follow-up...
We investigated trends in the incidence of parkinsonism and Parkinson disease (PD) by comparing data from first 2 subcohorts Rotterdam Study, a prospective, population-based cohort study (first subcohort: baseline 1990 with 10 years follow-up; second subcohort, 2000 follow-up). From years, we observed differences subcohort that were associated lower risk PD for some but not all factors. Participants both followed maximum monitored onset parkinsonism, dementia, or death, until January 1,...
MicroRNAs (miRNAs) are small noncoding RNAs that serve as key regulators of gene expression. They have been shown to be involved in a wide range biological processes including neurodegenerative diseases. Genetic variants miRNAs or miRNA-binding sites on their target genes could affect miRNA function and contribute disease risk. Here, we investigated the association miRNA-related genetic with Parkinson (PD) using data from largest GWAS PD. Of 243 variants, identified rs897984:T>C miR-4519 (P...